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Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides.
Oxid Med Cell Longev. 2017; 2017:1038153.OM

Abstract

Propolis is a natural mixture of compounds produced by various bee species, including stingless bees. This compound has been shown to exhibit antioxidant, antiproliferative, and antitumor activities. The present study aimed to determine the chemical constituents as well as the antioxidant, cytotoxic, and toxic activities of ethanol extracts of propolis obtained from the stingless bees Scaptotrigona depilis and Melipona quadrifasciata anthidioides, which are found in Brazil. Phytosterols, terpenes, phenolic compounds, and tocopherol were identified in the ethanol extracts of propolis (EEPs) in different concentrations. The compounds stigmasterol, taraxasterol, vanilic acid, caffeic acid, quercetin, luteolin, and apigenin were found only in EEP-M. The EEPs were able to scavenge the free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and protected human erythrocytes against lipid peroxidation, with the latter effect being demonstrated by their antihemolytic activity and inhibition of malondialdehyde formation. The EEPs showed cytotoxic activity against erythroleukemic cells and necrosis was the main mechanism of death observed. In addition, the concentrations at which the EEPs were cytotoxic were not toxic against Caenorhabditis elegans. In this context, it is concluded that EEP-S and EEP-M show antioxidant and cytotoxic activities and are promising bioactive mixtures for the control of diseases associated with oxidative stress and tumor cell proliferation.

Authors+Show Affiliations

School of Environmental and Biological Science, Federal University of Grande Dourados, Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Dourados, MS, Brazil.Course of Chemistry, State University of Mato Grosso do Sul, Dourados, MS, Brazil.Department of Biochemistry, Federal University of São Paulo, SP, Brazil; Interdisciplinary Center of Biochemistry Investigation, University of Mogi das Cruzes, Mogi das Cruzes, SP, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Dourados, MS, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28377794

Citation

Bonamigo, Thaliny, et al. "Antioxidant, Cytotoxic, and Toxic Activities of Propolis From Two Native Bees in Brazil: Scaptotrigona Depilis and Melipona Quadrifasciata Anthidioides." Oxidative Medicine and Cellular Longevity, vol. 2017, 2017, p. 1038153.
Bonamigo T, Campos JF, Alfredo TM, et al. Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides. Oxid Med Cell Longev. 2017;2017:1038153.
Bonamigo, T., Campos, J. F., Alfredo, T. M., Balestieri, J. B., Cardoso, C. A., Paredes-Gamero, E. J., de Picoli Souza, K., & Dos Santos, E. L. (2017). Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity, 2017, 1038153. https://doi.org/10.1155/2017/1038153
Bonamigo T, et al. Antioxidant, Cytotoxic, and Toxic Activities of Propolis From Two Native Bees in Brazil: Scaptotrigona Depilis and Melipona Quadrifasciata Anthidioides. Oxid Med Cell Longev. 2017;2017:1038153. PubMed PMID: 28377794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides. AU - Bonamigo,Thaliny, AU - Campos,Jaqueline Ferreira, AU - Alfredo,Tamaeh Monteiro, AU - Balestieri,José Benedito Perrella, AU - Cardoso,Claudia Andrea Lima, AU - Paredes-Gamero,Edgar Julian, AU - de Picoli Souza,Kely, AU - Dos Santos,Edson Lucas, Y1 - 2017/03/09/ PY - 2016/11/10/received PY - 2017/01/27/revised PY - 2017/02/01/accepted PY - 2017/4/6/entrez PY - 2017/4/6/pubmed PY - 2017/6/22/medline SP - 1038153 EP - 1038153 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2017 N2 - Propolis is a natural mixture of compounds produced by various bee species, including stingless bees. This compound has been shown to exhibit antioxidant, antiproliferative, and antitumor activities. The present study aimed to determine the chemical constituents as well as the antioxidant, cytotoxic, and toxic activities of ethanol extracts of propolis obtained from the stingless bees Scaptotrigona depilis and Melipona quadrifasciata anthidioides, which are found in Brazil. Phytosterols, terpenes, phenolic compounds, and tocopherol were identified in the ethanol extracts of propolis (EEPs) in different concentrations. The compounds stigmasterol, taraxasterol, vanilic acid, caffeic acid, quercetin, luteolin, and apigenin were found only in EEP-M. The EEPs were able to scavenge the free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and protected human erythrocytes against lipid peroxidation, with the latter effect being demonstrated by their antihemolytic activity and inhibition of malondialdehyde formation. The EEPs showed cytotoxic activity against erythroleukemic cells and necrosis was the main mechanism of death observed. In addition, the concentrations at which the EEPs were cytotoxic were not toxic against Caenorhabditis elegans. In this context, it is concluded that EEP-S and EEP-M show antioxidant and cytotoxic activities and are promising bioactive mixtures for the control of diseases associated with oxidative stress and tumor cell proliferation. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/28377794/Antioxidant_Cytotoxic_and_Toxic_Activities_of_Propolis_from_Two_Native_Bees_in_Brazil:_Scaptotrigona_depilis_and_Melipona_quadrifasciata_anthidioides_ L2 - https://dx.doi.org/10.1155/2017/1038153 DB - PRIME DP - Unbound Medicine ER -