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Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults.
Rev Inst Med Trop Sao Paulo. 2017 Apr 03; 59:e2.RI

Abstract

Introduction:

The World Health Organization (WHO) recommends one single dose of the Yellow Fever (YF) vaccine based on studies of antibody persistency in healthy adults. We assessed the prevalence and titers of YF virus neutralizing antibodies in previously vaccinated persons aged  60 years, in comparison to younger adults. We also evaluated the correlation between antibody titers and the time since vaccination among participants who received one vaccine dose, and the seropositivity among participants vaccinated prior to or within the past 10 years.

Methods:

previously vaccinated healthy persons aged  18 years were included. YF virus neutralizing antibody titers were determined by means of the 50% Plaque Reduction Neutralization Test.

Results:

46 persons aged  60 years and 48 persons aged 18 to 59 years were enrolled. There was no significant difference in the prevalence of YF virus neutralizing antibodies between the two groups (p = 0.263). However, titers were significantly lower in the elderly (p = 0.022). There was no correlation between YF virus neutralizing antibody titers and the time since vaccination. There was no significant difference in seropositivity among participants vaccinated prior to or within the past 10 years.

Conclusions:

the clinical relevance of the observed difference in YF virus neutralizing antibody titers between the two groups is not clear.

Authors+Show Affiliations

Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, SP, Brazil.Fundação Oswaldo Cruz, Laboratório de Tecnologia Virológica Bio-Manguinhos, Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz, Laboratório de Tecnologia Virológica Bio-Manguinhos, Rio de Janeiro, RJ, Brazil.Instituto Butantan, Hospital Vital Brazil, São Paulo, SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Departamento de Medicina Preventiva, São Paulo, SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Divisão de Imunologia Clínica e Alergia, São Paulo, SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Divisão de Imunologia Clínica e Alergia, São Paulo, SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, SP, Brazil.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28380113

Citation

Miyaji, Karina Takesaki, et al. "Prevalence and Titers of Yellow Fever Virus Neutralizing Antibodies in Previously Vaccinated Adults." Revista Do Instituto De Medicina Tropical De Sao Paulo, vol. 59, 2017, pp. e2.
Miyaji KT, Avelino-Silva VI, Simões M, et al. Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults. Rev Inst Med Trop Sao Paulo. 2017;59:e2.
Miyaji, K. T., Avelino-Silva, V. I., Simões, M., Freire, M. D., Medeiros, C. R., Braga, P. E., Neves, M. A., Lopes, M. H., Kallas, E. G., & Sartori, A. M. (2017). Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults. Revista Do Instituto De Medicina Tropical De Sao Paulo, 59, e2. https://doi.org/10.1590/S1678-9946201759002
Miyaji KT, et al. Prevalence and Titers of Yellow Fever Virus Neutralizing Antibodies in Previously Vaccinated Adults. Rev Inst Med Trop Sao Paulo. 2017 Apr 3;59:e2. PubMed PMID: 28380113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults. AU - Miyaji,Karina Takesaki, AU - Avelino-Silva,Vivian Iida, AU - Simões,Marisol, AU - Freire,Marcos da Silva, AU - Medeiros,Carlos Roberto de, AU - Braga,Patrícia Emilia, AU - Neves,Maria Angélica Acalá, AU - Lopes,Marta Heloisa, AU - Kallas,Esper Georges, AU - Sartori,Ana Marli Christovam, Y1 - 2017/04/03/ PY - 2016/01/27/received PY - 2016/09/22/accepted PY - 2017/4/6/entrez PY - 2017/4/6/pubmed PY - 2017/5/4/medline SP - e2 EP - e2 JF - Revista do Instituto de Medicina Tropical de Sao Paulo JO - Rev Inst Med Trop Sao Paulo VL - 59 N2 - Introduction:: The World Health Organization (WHO) recommends one single dose of the Yellow Fever (YF) vaccine based on studies of antibody persistency in healthy adults. We assessed the prevalence and titers of YF virus neutralizing antibodies in previously vaccinated persons aged  60 years, in comparison to younger adults. We also evaluated the correlation between antibody titers and the time since vaccination among participants who received one vaccine dose, and the seropositivity among participants vaccinated prior to or within the past 10 years. Methods: : previously vaccinated healthy persons aged  18 years were included. YF virus neutralizing antibody titers were determined by means of the 50% Plaque Reduction Neutralization Test. Results: : 46 persons aged  60 years and 48 persons aged 18 to 59 years were enrolled. There was no significant difference in the prevalence of YF virus neutralizing antibodies between the two groups (p = 0.263). However, titers were significantly lower in the elderly (p = 0.022). There was no correlation between YF virus neutralizing antibody titers and the time since vaccination. There was no significant difference in seropositivity among participants vaccinated prior to or within the past 10 years. Conclusions: : the clinical relevance of the observed difference in YF virus neutralizing antibody titers between the two groups is not clear. SN - 1678-9946 UR - https://www.unboundmedicine.com/medline/citation/28380113/Prevalence_and_titers_of_yellow_fever_virus_neutralizing_antibodies_in_previously_vaccinated_adults_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000200&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -