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ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism.
Cell Rep. 2017 04 04; 19(1):1-9.CR

Abstract

Hepatic lipid droplet (LD) catabolism is thought to occur via cytosolic lipases such as adipose triglyceride lipase (ATGL) or through autophagy of LDs, a process known as lipophagy. We tested the potential interplay between these metabolic processes and its effects on hepatic lipid metabolism. We show that hepatic ATGL is both necessary and sufficient to induce both autophagy and lipophagy. Moreover, lipophagy is required for ATGL to promote LD catabolism and the subsequent oxidation of hydrolyzed fatty acids (FAs). Following previous work showing that ATGL promotes sirtuin 1 (SIRT1) activity, studies in liver-specific SIRT1[-/-] mice and in primary hepatocytes reveal that SIRT1 is required for ATGL-mediated induction of autophagy and lipophagy. Taken together, these studies show that ATGL-mediated signaling via SIRT1 promotes autophagy/lipophagy as a primary means to control hepatic LD catabolism and FA oxidation.

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Authors+Show Affiliations

Sathyanarayan A
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.
Mashek MT
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Mashek DG
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: dmashek@umn.edu.

MeSH

Analysis of VarianceAnimalsAutophagyCells, CulturedFatty AcidsHepatocytesLipaseLipid DropletsLipid MetabolismLipolysisLiverMaleMiceMice, Inbred C57BLMicroscopy, FluorescenceOxidation-ReductionSirtuin 1

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28380348

Citation

Sathyanarayan, Aishwarya, et al. "ATGL Promotes Autophagy/Lipophagy Via SIRT1 to Control Hepatic Lipid Droplet Catabolism." Cell Reports, vol. 19, no. 1, 2017, pp. 1-9.
Sathyanarayan A, Mashek MT, Mashek DG. ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism. Cell Rep. 2017;19(1):1-9.
Sathyanarayan, A., Mashek, M. T., & Mashek, D. G. (2017). ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism. Cell Reports, 19(1), 1-9. https://doi.org/10.1016/j.celrep.2017.03.026
Sathyanarayan A, Mashek MT, Mashek DG. ATGL Promotes Autophagy/Lipophagy Via SIRT1 to Control Hepatic Lipid Droplet Catabolism. Cell Rep. 2017 04 4;19(1):1-9. PubMed PMID: 28380348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism. AU - Sathyanarayan,Aishwarya, AU - Mashek,Mara T, AU - Mashek,Douglas G, PY - 2016/11/22/received PY - 2016/12/21/revised PY - 2017/03/06/accepted PY - 2017/4/6/entrez PY - 2017/4/6/pubmed PY - 2017/12/19/medline KW - ATGL KW - SIRT1 KW - autophagy KW - fatty acid oxidation KW - lipid droplets KW - lipolysis KW - lipophagy KW - liver metabolism SP - 1 EP - 9 JF - Cell reports JO - Cell Rep VL - 19 IS - 1 N2 - Hepatic lipid droplet (LD) catabolism is thought to occur via cytosolic lipases such as adipose triglyceride lipase (ATGL) or through autophagy of LDs, a process known as lipophagy. We tested the potential interplay between these metabolic processes and its effects on hepatic lipid metabolism. We show that hepatic ATGL is both necessary and sufficient to induce both autophagy and lipophagy. Moreover, lipophagy is required for ATGL to promote LD catabolism and the subsequent oxidation of hydrolyzed fatty acids (FAs). Following previous work showing that ATGL promotes sirtuin 1 (SIRT1) activity, studies in liver-specific SIRT1[-/-] mice and in primary hepatocytes reveal that SIRT1 is required for ATGL-mediated induction of autophagy and lipophagy. Taken together, these studies show that ATGL-mediated signaling via SIRT1 promotes autophagy/lipophagy as a primary means to control hepatic LD catabolism and FA oxidation. SN - 2211-1247 UR - https://www.unboundmedicine.com/medline/citation/28380348/ATGL_Promotes_Autophagy/Lipophagy_via_SIRT1_to_Control_Hepatic_Lipid_Droplet_Catabolism_ DB - PRIME DP - Unbound Medicine ER -