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Long-term outcome of patients with chronic pancreatitis treated with micronutrient antioxidant therapy.
Hepatobiliary Pancreat Dis Int. 2017 Apr; 16(2):209-214.HP

Abstract

BACKGROUND

Micronutrient antioxidant therapy did not relieve pain in a European randomized trial of patients with chronic pancreatitis without malnutrition. However, intervention was undertaken only for 6 months leaving unanswered the question of whether long-term antioxidant therapy may modulate chronic pancreatitis. The aim of this study is to assess the outcome of long-term use of micronutrient antioxidant therapy in patients with chronic pancreatitis.

METHODS

This is a single center clinical cohort report of patients with chronic pancreatitis prescribed micronutrient antioxidant therapy and followed for up to 10 years. Data were collected on demographic detail, clinic pain assessment, insulin requirements, interventions and outcome.

RESULTS

A group of 30 patients with a diagnosis of chronic pancreatitis constitute the study population. Median age at time of diagnosis was 40 years (range 14-66); 19 (63%) were male and the median duration of symptoms was 2 years (range 0-18). Alcohol was the dominant cause in 22 (73%) patients and 16 (53%) patients were Cambridge stage 1. Twenty-four (80%) patients had pain at presentation. During antioxidant treatment of 4 years (range 1-10), pain decreased but the proportion with abdominal pain compared to those who were pain-free remained constant (P=0.16; two-way ANOVA with Bonferroni correction). There was a significant increase in requirement for insulin (P=0.028) with time together with use of both endoscopic and surgical interventions.

CONCLUSIONS

This is the first study to report long-term disease-specific outcome in patients with chronic pancreatitis prescribed micronutrient antioxidant therapy. There appears to be no effect of intervention on outcome.

Authors+Show Affiliations

Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK. ajith.siriwardena@cmft.nhs.uk.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28381387

Citation

Rupasinghe, Sukitha Namal, and Ajith K. Siriwardena. "Long-term Outcome of Patients With Chronic Pancreatitis Treated With Micronutrient Antioxidant Therapy." Hepatobiliary & Pancreatic Diseases International : HBPD INT, vol. 16, no. 2, 2017, pp. 209-214.
Rupasinghe SN, Siriwardena AK. Long-term outcome of patients with chronic pancreatitis treated with micronutrient antioxidant therapy. HBPD INT. 2017;16(2):209-214.
Rupasinghe, S. N., & Siriwardena, A. K. (2017). Long-term outcome of patients with chronic pancreatitis treated with micronutrient antioxidant therapy. Hepatobiliary & Pancreatic Diseases International : HBPD INT, 16(2), 209-214.
Rupasinghe SN, Siriwardena AK. Long-term Outcome of Patients With Chronic Pancreatitis Treated With Micronutrient Antioxidant Therapy. HBPD INT. 2017;16(2):209-214. PubMed PMID: 28381387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term outcome of patients with chronic pancreatitis treated with micronutrient antioxidant therapy. AU - Rupasinghe,Sukitha Namal, AU - Siriwardena,Ajith K, PY - 2017/4/7/entrez PY - 2017/4/7/pubmed PY - 2017/10/24/medline SP - 209 EP - 214 JF - Hepatobiliary & pancreatic diseases international : HBPD INT JO - HBPD INT VL - 16 IS - 2 N2 - BACKGROUND: Micronutrient antioxidant therapy did not relieve pain in a European randomized trial of patients with chronic pancreatitis without malnutrition. However, intervention was undertaken only for 6 months leaving unanswered the question of whether long-term antioxidant therapy may modulate chronic pancreatitis. The aim of this study is to assess the outcome of long-term use of micronutrient antioxidant therapy in patients with chronic pancreatitis. METHODS: This is a single center clinical cohort report of patients with chronic pancreatitis prescribed micronutrient antioxidant therapy and followed for up to 10 years. Data were collected on demographic detail, clinic pain assessment, insulin requirements, interventions and outcome. RESULTS: A group of 30 patients with a diagnosis of chronic pancreatitis constitute the study population. Median age at time of diagnosis was 40 years (range 14-66); 19 (63%) were male and the median duration of symptoms was 2 years (range 0-18). Alcohol was the dominant cause in 22 (73%) patients and 16 (53%) patients were Cambridge stage 1. Twenty-four (80%) patients had pain at presentation. During antioxidant treatment of 4 years (range 1-10), pain decreased but the proportion with abdominal pain compared to those who were pain-free remained constant (P=0.16; two-way ANOVA with Bonferroni correction). There was a significant increase in requirement for insulin (P=0.028) with time together with use of both endoscopic and surgical interventions. CONCLUSIONS: This is the first study to report long-term disease-specific outcome in patients with chronic pancreatitis prescribed micronutrient antioxidant therapy. There appears to be no effect of intervention on outcome. SN - 1499-3872 UR - https://www.unboundmedicine.com/medline/citation/28381387/Long_term_outcome_of_patients_with_chronic_pancreatitis_treated_with_micronutrient_antioxidant_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1499-3872(16)60128-5 DB - PRIME DP - Unbound Medicine ER -