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Intake of meat and fish and risk of head-neck cancer subtypes in the Netherlands Cohort Study.
Cancer Causes Control 2017; 28(6):647-656CC

Abstract

PURPOSE

To date, the role of meat and fish intake in head-neck cancer (HNC) etiology is not well understood and prospective evidence is limited. This prompted us to study the association between meat, fish, and HNC subtypes, i.e., oral cavity cancer (OCC), oro- and hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), within the Netherlands Cohort Study (NLCS).

METHODS

In 1986, 120,852 participants (aged 55-69 years) completed a baseline 150-item food frequency questionnaire (FFQ), from which daily meat and fish intake were calculated. After 20.3 years of follow-up, 430 HNC overall (134 OCC, 90 OHPC and 203 LC) cases and 4,111 subcohort members were found to be eligible for case-cohort analysis. Multivariate hazard ratios were calculated using Cox's proportional hazards model within quartiles of energy-adjusted meat and fish intake.

RESULTS

Processed meat intake, but not red meat intake, was positively associated with HNC overall [HR(Q4 vs. Q1) = 1.46, 95% CI 1.06-2.00; ptrend = 0.03]. Among HNC subtypes, processed meat was positively associated with OCC, while no associations were found with OHPC and LC. Fish intake was not associated with HNC risk. Tests for interaction did not reveal statistically significant interaction between meat, fish, and alcohol or smoking on HNC overall risk.

CONCLUSIONS

In this large cohort study, processed meat intake was positively associated with HNC overall and HNC subtype OCC, but not with OHPC and LC.

Authors+Show Affiliations

Department of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, Peter Debijeplein 1, 6229 HA, Maastricht, The Netherlands.Department of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, Peter Debijeplein 1, 6229 HA, Maastricht, The Netherlands.Department of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, Peter Debijeplein 1, 6229 HA, Maastricht, The Netherlands.Department of Otorhinolaryngology, Head and Neck Surgery, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.Department of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, Peter Debijeplein 1, 6229 HA, Maastricht, The Netherlands. lj.schouten@maastrichtuniversity.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28382514

Citation

Perloy, Andy, et al. "Intake of Meat and Fish and Risk of Head-neck Cancer Subtypes in the Netherlands Cohort Study." Cancer Causes & Control : CCC, vol. 28, no. 6, 2017, pp. 647-656.
Perloy A, Maasland DHE, van den Brandt PA, et al. Intake of meat and fish and risk of head-neck cancer subtypes in the Netherlands Cohort Study. Cancer Causes Control. 2017;28(6):647-656.
Perloy, A., Maasland, D. H. E., van den Brandt, P. A., Kremer, B., & Schouten, L. J. (2017). Intake of meat and fish and risk of head-neck cancer subtypes in the Netherlands Cohort Study. Cancer Causes & Control : CCC, 28(6), pp. 647-656. doi:10.1007/s10552-017-0892-0.
Perloy A, et al. Intake of Meat and Fish and Risk of Head-neck Cancer Subtypes in the Netherlands Cohort Study. Cancer Causes Control. 2017;28(6):647-656. PubMed PMID: 28382514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of meat and fish and risk of head-neck cancer subtypes in the Netherlands Cohort Study. AU - Perloy,Andy, AU - Maasland,Denise H E, AU - van den Brandt,Piet A, AU - Kremer,Bernd, AU - Schouten,Leo J, Y1 - 2017/04/05/ PY - 2016/03/23/received PY - 2017/03/29/accepted PY - 2017/4/7/pubmed PY - 2017/6/9/medline PY - 2017/4/7/entrez KW - Fish KW - Head–neck cancer KW - Meat KW - Prospective cohort studies KW - Risk factors SP - 647 EP - 656 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 28 IS - 6 N2 - PURPOSE: To date, the role of meat and fish intake in head-neck cancer (HNC) etiology is not well understood and prospective evidence is limited. This prompted us to study the association between meat, fish, and HNC subtypes, i.e., oral cavity cancer (OCC), oro- and hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), within the Netherlands Cohort Study (NLCS). METHODS: In 1986, 120,852 participants (aged 55-69 years) completed a baseline 150-item food frequency questionnaire (FFQ), from which daily meat and fish intake were calculated. After 20.3 years of follow-up, 430 HNC overall (134 OCC, 90 OHPC and 203 LC) cases and 4,111 subcohort members were found to be eligible for case-cohort analysis. Multivariate hazard ratios were calculated using Cox's proportional hazards model within quartiles of energy-adjusted meat and fish intake. RESULTS: Processed meat intake, but not red meat intake, was positively associated with HNC overall [HR(Q4 vs. Q1) = 1.46, 95% CI 1.06-2.00; ptrend = 0.03]. Among HNC subtypes, processed meat was positively associated with OCC, while no associations were found with OHPC and LC. Fish intake was not associated with HNC risk. Tests for interaction did not reveal statistically significant interaction between meat, fish, and alcohol or smoking on HNC overall risk. CONCLUSIONS: In this large cohort study, processed meat intake was positively associated with HNC overall and HNC subtype OCC, but not with OHPC and LC. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/28382514/Intake_of_meat_and_fish_and_risk_of_head_neck_cancer_subtypes_in_the_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1007/s10552-017-0892-0 DB - PRIME DP - Unbound Medicine ER -