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Iodine supplementation: comparison of oral or intramuscular iodized oil with oral potassium iodide. A controlled trial in Zaire.
Int J Epidemiol 1988; 17(1):142-7IJ

Abstract

A community-based controlled trial of iodine supplementation comparing oral or intramuscular iodized oil with oral potassium iodide has been carried out in 23 severely iodine-deficient villages in Eastern Zaire. The overall goitre prevalence in the population (n = 5999) was 61% and mean urinary iodine excretion in sample of 57 women 10.9 (SD 6.8) micrograms/g creatinine. All adults in three groups of four villages were given single doses of potassium iodide of 0.5 g, 1.0 g, and 2.0 g respectively. A fourth group was given oral iodized oil (2 ml) and a fifth placebo-treated. A further three villages were given intramuscular iodized oil (2 ml). The effectiveness of supplementation was assessed by measurements of bloodspot thyroxine (T4) concentration in women of reproductive age in the villages. The effects of iodide were small and inconsistent. Eight months after supplementation with oral iodized oil the distribution of T4 concentrations was similar to that seen with intramuscular oil. We conclude that oral iodized oil is an effective alternative to injected oil and would be feasible for iodine supplementation in remote areas with untrained people.

Authors+Show Affiliations

MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2838426

Citation

Phillips, D I., et al. "Iodine Supplementation: Comparison of Oral or Intramuscular Iodized Oil With Oral Potassium Iodide. a Controlled Trial in Zaire." International Journal of Epidemiology, vol. 17, no. 1, 1988, pp. 142-7.
Phillips DI, Lusty TD, Osmond C, et al. Iodine supplementation: comparison of oral or intramuscular iodized oil with oral potassium iodide. A controlled trial in Zaire. Int J Epidemiol. 1988;17(1):142-7.
Phillips, D. I., Lusty, T. D., Osmond, C., & Church, D. (1988). Iodine supplementation: comparison of oral or intramuscular iodized oil with oral potassium iodide. A controlled trial in Zaire. International Journal of Epidemiology, 17(1), pp. 142-7.
Phillips DI, et al. Iodine Supplementation: Comparison of Oral or Intramuscular Iodized Oil With Oral Potassium Iodide. a Controlled Trial in Zaire. Int J Epidemiol. 1988;17(1):142-7. PubMed PMID: 2838426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iodine supplementation: comparison of oral or intramuscular iodized oil with oral potassium iodide. A controlled trial in Zaire. AU - Phillips,D I, AU - Lusty,T D, AU - Osmond,C, AU - Church,D, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Biology KW - Comparative Studies KW - Deficiency Diseases KW - Developing Countries KW - Diseases KW - Endocrine Effects KW - Endocrine System KW - French Speaking Africa KW - Hematological Effects KW - Hemic System KW - Middle Africa KW - Nutrition Disorders KW - Physiology KW - Protein Bound Iodine Alterations KW - Thyroid Effects KW - Zaire SP - 142 EP - 7 JF - International journal of epidemiology JO - Int J Epidemiol VL - 17 IS - 1 N2 - A community-based controlled trial of iodine supplementation comparing oral or intramuscular iodized oil with oral potassium iodide has been carried out in 23 severely iodine-deficient villages in Eastern Zaire. The overall goitre prevalence in the population (n = 5999) was 61% and mean urinary iodine excretion in sample of 57 women 10.9 (SD 6.8) micrograms/g creatinine. All adults in three groups of four villages were given single doses of potassium iodide of 0.5 g, 1.0 g, and 2.0 g respectively. A fourth group was given oral iodized oil (2 ml) and a fifth placebo-treated. A further three villages were given intramuscular iodized oil (2 ml). The effectiveness of supplementation was assessed by measurements of bloodspot thyroxine (T4) concentration in women of reproductive age in the villages. The effects of iodide were small and inconsistent. Eight months after supplementation with oral iodized oil the distribution of T4 concentrations was similar to that seen with intramuscular oil. We conclude that oral iodized oil is an effective alternative to injected oil and would be feasible for iodine supplementation in remote areas with untrained people. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/2838426/Iodine_supplementation:_comparison_of_oral_or_intramuscular_iodized_oil_with_oral_potassium_iodide__A_controlled_trial_in_Zaire_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/17.1.142 DB - PRIME DP - Unbound Medicine ER -