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Extensive diversity of coronaviruses in bats from China.
Virology. 2017 07; 507:1-10.V

Abstract

To help reveal the diversity and evolution of bat coronaviruses we collected 1067 bats from 21 species in China. A total of 73 coronaviruses (32 alphacoronaviruses and 41 betacoronaviruses) were identified in these bats, with an overall prevalence of 6.84%. All newly-identified betacoronaviruses were SARS-related Rhinolophus bat coronaviruses (SARSr-Rh-BatCoV). Importantly, with the exception of the S gene, the genome sequences of the SARSr-Rh-BatCoVs sampled in Guizhou province were closely related to SARS-related human coronavirus. Additionally, the newly-identified alphacoronaviruses exhibited high genetic diversity and some may represent novel species. Our phylogenetic analyses also provided insights into the transmission of these viruses among bat species, revealing a general clustering by geographic location rather than by bat species. Inter-species transmission among bats from the same genus was also commonplace in both the alphacoronaviruses and betacoronaviruses. Overall, these data suggest that high contact rates among specific bat species enable the acquisition and spread of coronaviruses.

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Authors+Show Affiliations

Lin XD
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
Wang W
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
Hao ZY
Henan Center for Disease Control and Prevention, Zhengzhou, Henan Province, China.
Wang ZX
Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou Province, China.
Guo WP
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
Guan XQ
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
Wang MR
Longquan Center for Disease Control and Prevention, Longquan, Zhejiang Province, China.
Wang HW
Neixiang Center for Disease Control and Prevention, Neixiang, Henan Province, China.
Zhou RH
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
Li MH
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
Tang GP
Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou Province, China.
Wu J
Jiyuan Center for Disease Control and Prevention, Jiyuan, Henan Province, China.
Holmes EC
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.
Zhang YZ
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China. Electronic address: zhangyongzhen@icdc.cn.

MeSH

AnimalsChinaChiropteraCoronavirusGenetic VariationGenome, ViralPhylogenyRNA, Viral

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28384506

Citation

Lin, Xian-Dan, et al. "Extensive Diversity of Coronaviruses in Bats From China." Virology, vol. 507, 2017, pp. 1-10.
Lin XD, Wang W, Hao ZY, et al. Extensive diversity of coronaviruses in bats from China. Virology. 2017;507:1-10.
Lin, X. D., Wang, W., Hao, Z. Y., Wang, Z. X., Guo, W. P., Guan, X. Q., Wang, M. R., Wang, H. W., Zhou, R. H., Li, M. H., Tang, G. P., Wu, J., Holmes, E. C., & Zhang, Y. Z. (2017). Extensive diversity of coronaviruses in bats from China. Virology, 507, 1-10. https://doi.org/10.1016/j.virol.2017.03.019
Lin XD, et al. Extensive Diversity of Coronaviruses in Bats From China. Virology. 2017;507:1-10. PubMed PMID: 28384506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extensive diversity of coronaviruses in bats from China. AU - Lin,Xian-Dan, AU - Wang,Wen, AU - Hao,Zong-Yu, AU - Wang,Zhao-Xiao, AU - Guo,Wen-Ping, AU - Guan,Xiao-Qing, AU - Wang,Miao-Ruo, AU - Wang,Hong-Wei, AU - Zhou,Run-Hong, AU - Li,Ming-Hui, AU - Tang,Guang-Peng, AU - Wu,Jun, AU - Holmes,Edward C, AU - Zhang,Yong-Zhen, Y1 - 2017/04/03/ PY - 2017/02/12/received PY - 2017/03/27/revised PY - 2017/03/28/accepted PY - 2017/4/7/pubmed PY - 2017/7/18/medline PY - 2017/4/7/entrez KW - Bats KW - Coronavirus KW - Evolution KW - Phylogeny KW - SARS KW - Transmission SP - 1 EP - 10 JF - Virology JO - Virology VL - 507 N2 - To help reveal the diversity and evolution of bat coronaviruses we collected 1067 bats from 21 species in China. A total of 73 coronaviruses (32 alphacoronaviruses and 41 betacoronaviruses) were identified in these bats, with an overall prevalence of 6.84%. All newly-identified betacoronaviruses were SARS-related Rhinolophus bat coronaviruses (SARSr-Rh-BatCoV). Importantly, with the exception of the S gene, the genome sequences of the SARSr-Rh-BatCoVs sampled in Guizhou province were closely related to SARS-related human coronavirus. Additionally, the newly-identified alphacoronaviruses exhibited high genetic diversity and some may represent novel species. Our phylogenetic analyses also provided insights into the transmission of these viruses among bat species, revealing a general clustering by geographic location rather than by bat species. Inter-species transmission among bats from the same genus was also commonplace in both the alphacoronaviruses and betacoronaviruses. Overall, these data suggest that high contact rates among specific bat species enable the acquisition and spread of coronaviruses. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/28384506/Extensive_diversity_of_coronaviruses_in_bats_from_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(17)30100-9 DB - PRIME DP - Unbound Medicine ER -