Tags

Type your tag names separated by a space and hit enter

Is vertical transmission sufficient to maintain Junin virus in nature?
J Gen Virol. 1988 Jun; 69 (Pt 6):1437-40.JG

Abstract

The quantitative contribution of vertical transmission to the prevalence rate of Junin virus infection in subsequent generations of its natural reservoir, Calomys musculinus, was analysed. Data on mortality and reproduction of C. musculinus infected at birth with a wild strain of Junin virus were used to estimate the infection-dependent relative survival rate (beta = 0.4849) and relative fertility of the infected host (alpha = 0.2088). Prevalence rates of infection, obtained by mathematical simulation in optimal conditions of vertical transfer, dropped steadily to zero in a few generations. Vertical transmission was found to be insufficient to overcome the effect of highly depressed survival and fertility of the infected host and maintain a stabilized prevalence of Junin virus infection in successive generations; this suggested that viral maintenance is mainly dependent upon horizontal transmission.

Authors+Show Affiliations

Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2838581

Citation

Vitullo, A D., and M S. Merani. "Is Vertical Transmission Sufficient to Maintain Junin Virus in Nature?" The Journal of General Virology, vol. 69 (Pt 6), 1988, pp. 1437-40.
Vitullo AD, Merani MS. Is vertical transmission sufficient to maintain Junin virus in nature? J Gen Virol. 1988;69 (Pt 6):1437-40.
Vitullo, A. D., & Merani, M. S. (1988). Is vertical transmission sufficient to maintain Junin virus in nature? The Journal of General Virology, 69 (Pt 6), 1437-40.
Vitullo AD, Merani MS. Is Vertical Transmission Sufficient to Maintain Junin Virus in Nature. J Gen Virol. 1988;69 (Pt 6):1437-40. PubMed PMID: 2838581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is vertical transmission sufficient to maintain Junin virus in nature? AU - Vitullo,A D, AU - Merani,M S, PY - 1988/6/1/pubmed PY - 1988/6/1/medline PY - 1988/6/1/entrez SP - 1437 EP - 40 JF - The Journal of general virology JO - J Gen Virol VL - 69 (Pt 6) N2 - The quantitative contribution of vertical transmission to the prevalence rate of Junin virus infection in subsequent generations of its natural reservoir, Calomys musculinus, was analysed. Data on mortality and reproduction of C. musculinus infected at birth with a wild strain of Junin virus were used to estimate the infection-dependent relative survival rate (beta = 0.4849) and relative fertility of the infected host (alpha = 0.2088). Prevalence rates of infection, obtained by mathematical simulation in optimal conditions of vertical transfer, dropped steadily to zero in a few generations. Vertical transmission was found to be insufficient to overcome the effect of highly depressed survival and fertility of the infected host and maintain a stabilized prevalence of Junin virus infection in successive generations; this suggested that viral maintenance is mainly dependent upon horizontal transmission. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/2838581/Is_vertical_transmission_sufficient_to_maintain_Junin_virus_in_nature L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/0022-1317-69-6-1437 DB - PRIME DP - Unbound Medicine ER -