Tags

Type your tag names separated by a space and hit enter

Parental diuron-exposure alters offspring transcriptome and fitness in Pacific oyster Crassostrea gigas.
Ecotoxicol Environ Saf. 2017 Aug; 142:51-58.EE

Abstract

One of the primary challenges in ecotoxicology is to contribute to the assessment of the ecological status of ecosystems. In this study, we used Pacific oyster Crassostrea gigas to explore the effects of a parental exposure to diuron, a herbicide frequently detected in marine coastal environments. The present toxicogenomic study provides evidence that exposure of oyster genitors to diuron during gametogenesis results in changes in offspring, namely, transcriptomic profile alterations, increased global DNA methylation levels and reduced growth and survival within the first year of life. Importantly, we highlighted the limitations to identify particular genes or gene expression signatures that could serve as biomarkers for parental herbicide-exposure and further for multigenerational and transgenerational effects of specific chemical stressors. By analyzing samples from two independent experiments, we demonstrated that, due to complex confounding effects with both tested solvent vehicles, diuron non-specifically affected the offspring transcriptome. These original results question the potential development of predictive genomic tools for detecting specific indirect impacts of contaminants in environmental risk assessments. However, our results indicate that chronic environmental exposure to diuron over several generations may have significant long term impacts on oyster populations with adverse health outcomes.

Authors+Show Affiliations

Ifremer, UMR 5244, IHPE Interactions-Hosts-Pathogens-Environments, UPVD, CNRS, Université de Montpellier, CC 80, F-34095 Montpellier, France. Electronic address: ebachere@ifremer.fr.Ifremer, Laboratoire d'Ecotoxicologie, Rue de l'Ile d'Yeu, BP21105, 44311 Nantes cedex 03, France.Acobiom, 1682 rue de la Valsière, CS 77394 Cap Delta Biopole Euromédecine II, 34184 Montpellier Cedex 04, France.Ifremer, Laboratoire d'Ecotoxicologie, Rue de l'Ile d'Yeu, BP21105, 44311 Nantes cedex 03, France.Ifremer, Laboratoire d'Ecotoxicologie, Rue de l'Ile d'Yeu, BP21105, 44311 Nantes cedex 03, France.Acobiom, 1682 rue de la Valsière, CS 77394 Cap Delta Biopole Euromédecine II, 34184 Montpellier Cedex 04, France; Diag4Zoo, 1 rue des Loutres, 34170 Montpellier, France.Ifremer, Laboratoire d'Ecotoxicologie, Rue de l'Ile d'Yeu, BP21105, 44311 Nantes cedex 03, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28388477

Citation

Bachère, Evelyne, et al. "Parental Diuron-exposure Alters Offspring Transcriptome and Fitness in Pacific Oyster Crassostrea Gigas." Ecotoxicology and Environmental Safety, vol. 142, 2017, pp. 51-58.
Bachère E, Barranger A, Bruno R, et al. Parental diuron-exposure alters offspring transcriptome and fitness in Pacific oyster Crassostrea gigas. Ecotoxicol Environ Saf. 2017;142:51-58.
Bachère, E., Barranger, A., Bruno, R., Rouxel, J., Menard, D., Piquemal, D., & Akcha, F. (2017). Parental diuron-exposure alters offspring transcriptome and fitness in Pacific oyster Crassostrea gigas. Ecotoxicology and Environmental Safety, 142, 51-58. https://doi.org/10.1016/j.ecoenv.2017.03.030
Bachère E, et al. Parental Diuron-exposure Alters Offspring Transcriptome and Fitness in Pacific Oyster Crassostrea Gigas. Ecotoxicol Environ Saf. 2017;142:51-58. PubMed PMID: 28388477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental diuron-exposure alters offspring transcriptome and fitness in Pacific oyster Crassostrea gigas. AU - Bachère,Evelyne, AU - Barranger,Audrey, AU - Bruno,Roman, AU - Rouxel,Julien, AU - Menard,Dominique, AU - Piquemal,David, AU - Akcha,Farida, Y1 - 2017/04/05/ PY - 2017/01/05/received PY - 2017/03/20/revised PY - 2017/03/21/accepted PY - 2017/4/8/pubmed PY - 2017/9/16/medline PY - 2017/4/8/entrez KW - Biomarkers KW - Global DNA-methylation KW - Herbicide KW - Marine bivalve KW - Survival KW - Toxicogenomics SP - 51 EP - 58 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 142 N2 - One of the primary challenges in ecotoxicology is to contribute to the assessment of the ecological status of ecosystems. In this study, we used Pacific oyster Crassostrea gigas to explore the effects of a parental exposure to diuron, a herbicide frequently detected in marine coastal environments. The present toxicogenomic study provides evidence that exposure of oyster genitors to diuron during gametogenesis results in changes in offspring, namely, transcriptomic profile alterations, increased global DNA methylation levels and reduced growth and survival within the first year of life. Importantly, we highlighted the limitations to identify particular genes or gene expression signatures that could serve as biomarkers for parental herbicide-exposure and further for multigenerational and transgenerational effects of specific chemical stressors. By analyzing samples from two independent experiments, we demonstrated that, due to complex confounding effects with both tested solvent vehicles, diuron non-specifically affected the offspring transcriptome. These original results question the potential development of predictive genomic tools for detecting specific indirect impacts of contaminants in environmental risk assessments. However, our results indicate that chronic environmental exposure to diuron over several generations may have significant long term impacts on oyster populations with adverse health outcomes. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/28388477/Parental_diuron_exposure_alters_offspring_transcriptome_and_fitness_in_Pacific_oyster_Crassostrea_gigas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(17)30173-2 DB - PRIME DP - Unbound Medicine ER -