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Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis by Optical Coherence Tomography Angiography.
Invest Ophthalmol Vis Sci. 2017 04 01; 58(4):2087-2094.IO

Abstract

Purpose

To investigate microvascular changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in eyes with resolved branch retinal vein occlusion (BRVO) and their association with best-corrected visual acuity (BCVA).

Methods

Eighty-five eyes (82 consecutive patients) with BRVO after resolution of the macular edema were retrospectively evaluated. All patients underwent optical coherence tomography angiography (OCTA) for assessment of microvascular changes, including capillary telangiectasia, microaneurysm, and disruption of the foveal avascular zone (FAZ). The areas of vascular perfusion and FAZ in the SCP and DCP were quantitatively evaluated. Best-corrected visual acuity was measured on the same day as OCTA examination. The correlation between BCVA and OCTA findings was assessed.

Results

In eyes with resolved BRVO, the mean vascular perfusion areas in the SCP and DCP within a 3 × 3-mm area were 3.75 ± 0.49 and 3.80 ± 0.55 mm2, respectively. The mean FAZ areas of the SCP and DCP were 0.57 ± 0.36 and 0.76 ± 0.38 mm2, respectively. Better BCVA was significantly associated with a larger vascular perfusion area in the SCP (P < 0.001) and DCP (P < 0.001), and a smaller FAZ area in the SCP (P = 0.025) and DCP (P = 0.017). Stepwise multiple regression analysis revealed that the vascular perfusion area in the DCP was the most important parameter significantly correlated with BCVA (R2 = 0.33, P < 0.001).

Conclusions

Preservation of the deep retinal vasculature is crucial for better visual function in BRVO.

Authors+Show Affiliations

Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28388705

Citation

Wakabayashi, Taku, et al. "Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis By Optical Coherence Tomography Angiography." Investigative Ophthalmology & Visual Science, vol. 58, no. 4, 2017, pp. 2087-2094.
Wakabayashi T, Sato T, Hara-Ueno C, et al. Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis by Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2017;58(4):2087-2094.
Wakabayashi, T., Sato, T., Hara-Ueno, C., Fukushima, Y., Sayanagi, K., Shiraki, N., Sawa, M., Ikuno, Y., Sakaguchi, H., & Nishida, K. (2017). Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis by Optical Coherence Tomography Angiography. Investigative Ophthalmology & Visual Science, 58(4), 2087-2094. https://doi.org/10.1167/iovs.16-21208
Wakabayashi T, et al. Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis By Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2017 04 1;58(4):2087-2094. PubMed PMID: 28388705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis by Optical Coherence Tomography Angiography. AU - Wakabayashi,Taku, AU - Sato,Tatsuhiko, AU - Hara-Ueno,Chikako, AU - Fukushima,Yoko, AU - Sayanagi,Kaori, AU - Shiraki,Nobuhiko, AU - Sawa,Miki, AU - Ikuno,Yasushi, AU - Sakaguchi,Hirokazu, AU - Nishida,Kohji, PY - 2017/4/8/entrez PY - 2017/4/8/pubmed PY - 2017/6/27/medline SP - 2087 EP - 2094 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 58 IS - 4 N2 - Purpose: To investigate microvascular changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in eyes with resolved branch retinal vein occlusion (BRVO) and their association with best-corrected visual acuity (BCVA). Methods: Eighty-five eyes (82 consecutive patients) with BRVO after resolution of the macular edema were retrospectively evaluated. All patients underwent optical coherence tomography angiography (OCTA) for assessment of microvascular changes, including capillary telangiectasia, microaneurysm, and disruption of the foveal avascular zone (FAZ). The areas of vascular perfusion and FAZ in the SCP and DCP were quantitatively evaluated. Best-corrected visual acuity was measured on the same day as OCTA examination. The correlation between BCVA and OCTA findings was assessed. Results: In eyes with resolved BRVO, the mean vascular perfusion areas in the SCP and DCP within a 3 × 3-mm area were 3.75 ± 0.49 and 3.80 ± 0.55 mm2, respectively. The mean FAZ areas of the SCP and DCP were 0.57 ± 0.36 and 0.76 ± 0.38 mm2, respectively. Better BCVA was significantly associated with a larger vascular perfusion area in the SCP (P < 0.001) and DCP (P < 0.001), and a smaller FAZ area in the SCP (P = 0.025) and DCP (P = 0.017). Stepwise multiple regression analysis revealed that the vascular perfusion area in the DCP was the most important parameter significantly correlated with BCVA (R2 = 0.33, P < 0.001). Conclusions: Preservation of the deep retinal vasculature is crucial for better visual function in BRVO. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/28388705/Retinal_Microvasculature_and_Visual_Acuity_in_Eyes_With_Branch_Retinal_Vein_Occlusion:_Imaging_Analysis_by_Optical_Coherence_Tomography_Angiography_ DB - PRIME DP - Unbound Medicine ER -