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Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.
Mol Microbiol. 2017 07; 105(1):84-97.MM

Abstract

Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl1+ gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner.

Authors+Show Affiliations

Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.Department of Biological Science, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan.Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28388826

Citation

Ohtsuka, Hokuto, et al. "Sulfur Restriction Extends Fission Yeast Chronological Lifespan Through Ecl1 Family Genes By Downregulation of Ribosome." Molecular Microbiology, vol. 105, no. 1, 2017, pp. 84-97.
Ohtsuka H, Takinami M, Shimasaki T, et al. Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome. Mol Microbiol. 2017;105(1):84-97.
Ohtsuka, H., Takinami, M., Shimasaki, T., Hibi, T., Murakami, H., & Aiba, H. (2017). Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome. Molecular Microbiology, 105(1), 84-97. https://doi.org/10.1111/mmi.13686
Ohtsuka H, et al. Sulfur Restriction Extends Fission Yeast Chronological Lifespan Through Ecl1 Family Genes By Downregulation of Ribosome. Mol Microbiol. 2017;105(1):84-97. PubMed PMID: 28388826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome. AU - Ohtsuka,Hokuto, AU - Takinami,Masahiro, AU - Shimasaki,Takafumi, AU - Hibi,Takahide, AU - Murakami,Hiroshi, AU - Aiba,Hirofumi, Y1 - 2017/05/03/ PY - 2016/12/28/received PY - 2017/03/20/revised PY - 2017/03/30/accepted PY - 2017/4/8/pubmed PY - 2017/10/31/medline PY - 2017/4/8/entrez SP - 84 EP - 97 JF - Molecular microbiology JO - Mol Microbiol VL - 105 IS - 1 N2 - Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl1+ gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner. SN - 1365-2958 UR - https://www.unboundmedicine.com/medline/citation/28388826/Sulfur_restriction_extends_fission_yeast_chronological_lifespan_through_Ecl1_family_genes_by_downregulation_of_ribosome_ L2 - https://doi.org/10.1111/mmi.13686 DB - PRIME DP - Unbound Medicine ER -