Tags

Type your tag names separated by a space and hit enter

In vivo toxicity evaluation of aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb. fruit.
Regul Toxicol Pharmacol 2017; 86:349-355RT

Abstract

Terminalia bellirica (Gaertn.) Roxb. (Family: Combretaceae), known as Bhibhitaki in Sanskrit and locally known as Behera in India is one of the oldest medicinal plants which has widely been used in the traditional system of medicine, especially in Ayurveda for centuries. The dried fruit of Terminalia bellirica is used for treating various ailments. Aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb fruits (AATB), showed antioxidant potential in our screening study is selected for the present in vivo toxicity evaluation. Acute administration of AATB was done in female Wistar Albino rats as a single dose up to 2000 mg/kg body weight. At the end of the study, Blood was collected for biochemical and hematological analyses, while histological examinations were performed on liver and kidney. There was no alteration in the behavioral pattern, food and water intake in the treated animals. The relative organ weight, biochemical parameters, hematological parameters and histopathological analysis were also found normal. All the parameters of the toxicity evaluation were found to be normal and the data suggests aqueous acetone extract of Terminalia bellirica fruit is safe, to be used as a traditional herbal formulation for its antioxidant potential and other health benefits.

Authors+Show Affiliations

School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India. Electronic address: mslathasbs@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28389325

Citation

Jayesh, Kuriakose, et al. "In Vivo Toxicity Evaluation of Aqueous Acetone Extract of Terminalia Bellirica (Gaertn.) Roxb. Fruit." Regulatory Toxicology and Pharmacology : RTP, vol. 86, 2017, pp. 349-355.
Jayesh K, Helen LR, Vysakh A, et al. In vivo toxicity evaluation of aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb. fruit. Regul Toxicol Pharmacol. 2017;86:349-355.
Jayesh, K., Helen, L. R., Vysakh, A., Binil, E., & Latha, M. S. (2017). In vivo toxicity evaluation of aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb. fruit. Regulatory Toxicology and Pharmacology : RTP, 86, pp. 349-355. doi:10.1016/j.yrtph.2017.04.002.
Jayesh K, et al. In Vivo Toxicity Evaluation of Aqueous Acetone Extract of Terminalia Bellirica (Gaertn.) Roxb. Fruit. Regul Toxicol Pharmacol. 2017;86:349-355. PubMed PMID: 28389325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo toxicity evaluation of aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb. fruit. AU - Jayesh,Kuriakose, AU - Helen,Lal Raisa, AU - Vysakh,A, AU - Binil,Eldhose, AU - Latha,M S, Y1 - 2017/04/04/ PY - 2016/12/26/received PY - 2017/03/30/revised PY - 2017/04/02/accepted PY - 2017/4/9/pubmed PY - 2018/4/11/medline PY - 2017/4/9/entrez KW - Acute toxicity study KW - Aqueous acetone extract KW - Lethal dose KW - Terminalia bellirica SP - 349 EP - 355 JF - Regulatory toxicology and pharmacology : RTP JO - Regul. Toxicol. Pharmacol. VL - 86 N2 - Terminalia bellirica (Gaertn.) Roxb. (Family: Combretaceae), known as Bhibhitaki in Sanskrit and locally known as Behera in India is one of the oldest medicinal plants which has widely been used in the traditional system of medicine, especially in Ayurveda for centuries. The dried fruit of Terminalia bellirica is used for treating various ailments. Aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb fruits (AATB), showed antioxidant potential in our screening study is selected for the present in vivo toxicity evaluation. Acute administration of AATB was done in female Wistar Albino rats as a single dose up to 2000 mg/kg body weight. At the end of the study, Blood was collected for biochemical and hematological analyses, while histological examinations were performed on liver and kidney. There was no alteration in the behavioral pattern, food and water intake in the treated animals. The relative organ weight, biochemical parameters, hematological parameters and histopathological analysis were also found normal. All the parameters of the toxicity evaluation were found to be normal and the data suggests aqueous acetone extract of Terminalia bellirica fruit is safe, to be used as a traditional herbal formulation for its antioxidant potential and other health benefits. SN - 1096-0295 UR - https://www.unboundmedicine.com/medline/citation/28389325/In_vivo_toxicity_evaluation_of_aqueous_acetone_extract_of_Terminalia_bellirica_(Gaertn.)_Roxb._fruit L2 - https://linkinghub.elsevier.com/retrieve/pii/S0273-2300(17)30087-9 DB - PRIME DP - Unbound Medicine ER -