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Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity.
Environ Res. 2017 07; 156:326-333.ER

Abstract

OBJECTIVE

To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children.

METHODS

Among participants (N=249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (∑Di(2-ethylhexyl phthalate), ∑high molecular weight, ∑low molecular weight) with measures of weight status and adiposity in children aged 8-14 years. Linear regressions with specific-gravity corrected and natural log-transformed urinary concentrations were estimated, adjusting for covariates. Effect modification by sex was explored.

RESULTS

Prenatal urinary exposure to monobenzyl phthalate (MBzP) was inversely associated with child's BMI z-score (β=-0.21, 95%CI: -0.41, -0.02) and child urinary exposure to mono(2-ethylhexyl)phthalate (MEHP) was inversely associated with waist circumference (β=-1.85, 95%CI: -3.36, -0.35) and sum of skinfold thicknesses (β=-2.08, 95%CI: -3.80, -0.37) after adjusting for confounders. In the childhood exposure period, sex modified the relationships with BPA, MEHP, MBzP, monoethyl phthalate (MEP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP). In girls, increased BPA exposure was positively associated with sum of skinfold thickness (β=3.47, 95%CI: 0.05, 6.40) while increased MEHP was inversely associated with sum of skinfold thicknesses in boys (β=-2.95, 95%CI: -5.08, -0.82); these results remained in sensitivity analyses after excluding children who had initiated pubertal development (Tanner stage >1 for pubic hair). We did not observe relationships between summed phthalates metabolites at any exposure period with outcome measures.

CONCLUSION

Our results identified associations between urinary BPA and phthalates metabolites with measures of weight status and adiposity that differed by timing of exposure, sex, and pubertal status. Additional studies are needed to explore how associations may differ between those who are pre- and post-pubertal.

Authors+Show Affiliations

Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA; Department of Health Sciences, University of York, Heslington, York YO10 5DD, United Kingdom.Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA; Center for Human Growth and Development, University of Michigan, 300 North Ingalls St., Ann Arbor, MI 48109, USA. Electronic address: karenep@umich.edu.Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA; Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28390300

Citation

Yang, Tiffany C., et al. "Bisphenol a and Phthalates in Utero and in Childhood: Association With Child BMI Z-score and Adiposity." Environmental Research, vol. 156, 2017, pp. 326-333.
Yang TC, Peterson KE, Meeker JD, et al. Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity. Environ Res. 2017;156:326-333.
Yang, T. C., Peterson, K. E., Meeker, J. D., Sánchez, B. N., Zhang, Z., Cantoral, A., Solano, M., & Tellez-Rojo, M. M. (2017). Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity. Environmental Research, 156, 326-333. https://doi.org/10.1016/j.envres.2017.03.038
Yang TC, et al. Bisphenol a and Phthalates in Utero and in Childhood: Association With Child BMI Z-score and Adiposity. Environ Res. 2017;156:326-333. PubMed PMID: 28390300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity. AU - Yang,Tiffany C, AU - Peterson,Karen E, AU - Meeker,John D, AU - Sánchez,Brisa N, AU - Zhang,Zhenzhen, AU - Cantoral,Alejandra, AU - Solano,Maritsa, AU - Tellez-Rojo,Martha M, Y1 - 2017/04/05/ PY - 2016/10/20/received PY - 2017/03/24/revised PY - 2017/03/26/accepted PY - 2017/07/01/pmc-release PY - 2017/4/9/pubmed PY - 2017/6/24/medline PY - 2017/4/9/entrez KW - Adiposity KW - Adolescence KW - BMI KW - Bisphenol A KW - Phthalates SP - 326 EP - 333 JF - Environmental research JO - Environ. Res. VL - 156 N2 - OBJECTIVE: To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. METHODS: Among participants (N=249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (∑Di(2-ethylhexyl phthalate), ∑high molecular weight, ∑low molecular weight) with measures of weight status and adiposity in children aged 8-14 years. Linear regressions with specific-gravity corrected and natural log-transformed urinary concentrations were estimated, adjusting for covariates. Effect modification by sex was explored. RESULTS: Prenatal urinary exposure to monobenzyl phthalate (MBzP) was inversely associated with child's BMI z-score (β=-0.21, 95%CI: -0.41, -0.02) and child urinary exposure to mono(2-ethylhexyl)phthalate (MEHP) was inversely associated with waist circumference (β=-1.85, 95%CI: -3.36, -0.35) and sum of skinfold thicknesses (β=-2.08, 95%CI: -3.80, -0.37) after adjusting for confounders. In the childhood exposure period, sex modified the relationships with BPA, MEHP, MBzP, monoethyl phthalate (MEP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP). In girls, increased BPA exposure was positively associated with sum of skinfold thickness (β=3.47, 95%CI: 0.05, 6.40) while increased MEHP was inversely associated with sum of skinfold thicknesses in boys (β=-2.95, 95%CI: -5.08, -0.82); these results remained in sensitivity analyses after excluding children who had initiated pubertal development (Tanner stage >1 for pubic hair). We did not observe relationships between summed phthalates metabolites at any exposure period with outcome measures. CONCLUSION: Our results identified associations between urinary BPA and phthalates metabolites with measures of weight status and adiposity that differed by timing of exposure, sex, and pubertal status. Additional studies are needed to explore how associations may differ between those who are pre- and post-pubertal. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/28390300/Bisphenol_A_and_phthalates_in_utero_and_in_childhood:_association_with_child_BMI_z_score_and_adiposity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(16)30815-5 DB - PRIME DP - Unbound Medicine ER -