Tags

Type your tag names separated by a space and hit enter

Autoantibodies, detection methods and panels for diagnosis of Sjögren's syndrome.
Clin Immunol. 2017 09; 182:24-29.CI

Abstract

The presence of autoantibodies is one of several hallmarks of Sjögren's Syndrome, the detection of serum autoantibodies has a central role in the diagnosis and classification of Sjögren's syndrome. In this review, we will discuss autoantibodies that are helpful in the diagnosis of Sjögren's syndrome. This includes the traditional autoantibodies for disease classification (ANA, Anti-Ro/SSA, Anti-La/SSB, RF), autoantibodies identified from mouse models (Anti-SP1, Anti- PSP, Anti-CA6, and anti-alpha fodrin) and autoantibodies associated with other autoimmune disease (ACA, AMA, and Anti-CCP). We will also review the methods for the detection of autoantibodies and associated challenges for clinical results reporting. The significance of using an autoantibody panel for the diagnosis of SS will be also be reviewed.

Authors+Show Affiliations

Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, China; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA. Electronic address: shenl@buffalo.edu.Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28390965

Citation

Shen, Long, and Lakshmanan Suresh. "Autoantibodies, Detection Methods and Panels for Diagnosis of Sjögren's Syndrome." Clinical Immunology (Orlando, Fla.), vol. 182, 2017, pp. 24-29.
Shen L, Suresh L. Autoantibodies, detection methods and panels for diagnosis of Sjögren's syndrome. Clin Immunol. 2017;182:24-29.
Shen, L., & Suresh, L. (2017). Autoantibodies, detection methods and panels for diagnosis of Sjögren's syndrome. Clinical Immunology (Orlando, Fla.), 182, 24-29. https://doi.org/10.1016/j.clim.2017.03.017
Shen L, Suresh L. Autoantibodies, Detection Methods and Panels for Diagnosis of Sjögren's Syndrome. Clin Immunol. 2017;182:24-29. PubMed PMID: 28390965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoantibodies, detection methods and panels for diagnosis of Sjögren's syndrome. AU - Shen,Long, AU - Suresh,Lakshmanan, Y1 - 2017/04/05/ PY - 2017/01/04/received PY - 2017/03/31/accepted PY - 2017/4/10/pubmed PY - 2017/11/7/medline PY - 2017/4/10/entrez KW - Autoantibodies KW - Detection methods KW - Sjögren's syndrome SP - 24 EP - 29 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 182 N2 - The presence of autoantibodies is one of several hallmarks of Sjögren's Syndrome, the detection of serum autoantibodies has a central role in the diagnosis and classification of Sjögren's syndrome. In this review, we will discuss autoantibodies that are helpful in the diagnosis of Sjögren's syndrome. This includes the traditional autoantibodies for disease classification (ANA, Anti-Ro/SSA, Anti-La/SSB, RF), autoantibodies identified from mouse models (Anti-SP1, Anti- PSP, Anti-CA6, and anti-alpha fodrin) and autoantibodies associated with other autoimmune disease (ACA, AMA, and Anti-CCP). We will also review the methods for the detection of autoantibodies and associated challenges for clinical results reporting. The significance of using an autoantibody panel for the diagnosis of SS will be also be reviewed. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/28390965/Autoantibodies_detection_methods_and_panels_for_diagnosis_of_Sjögren's_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(17)30010-4 DB - PRIME DP - Unbound Medicine ER -