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Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study.
Nat Prod Res. 2018 Feb; 32(4):463-467.NP

Abstract

Disease progression in Tuberculosis (TB) is dependent on host's immune system. Phyllanthus niruri, a traditional herb, has long been used to boost immune system in Indonesian society. This study aimed to observe the potential role of P. niruri in inducing immune cells activity in TB patients by in vitro approach. Peripheral blood mononuclear cells (PBMCs) and macrophages were collected from active pulmonary TB patients. After stimulation with graded doses of P. niruri aqueous extract, cell proliferation, phagocytic activity and nitric oxide (NO) release were analysed. P. niruri aqueous extract induced proliferation of PBMCs, increased NO release, and improved macrophages phagocytic activity. These effects were observed in a dose-dependent manner. This may lead to further research for the potential role of P. niruri as immunomodulatory adjuvant therapy for TB patients.

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Authors+Show Affiliations

Putri DU
a Faculty of Medicine, Graduate Program of Medical and Health Science , Universitas Gadjah Mada , Yogyakarta , Indonesia.
Rintiswati N
b Faculty of Medicine, Department of Microbiology , Universitas Gadjah Mada , Yogyakarta , Indonesia.
Soesatyo MH
c Faculty of Medicine, Department of Histology and Cell Biology, Universitas Gadjah Mada , Universitas Gadjah Mada , Yogyakarta , Indonesia.
Haryana SM
c Faculty of Medicine, Department of Histology and Cell Biology, Universitas Gadjah Mada , Universitas Gadjah Mada , Yogyakarta , Indonesia.

MeSH

Adjuvants, ImmunologicAdultAntioxidantsCell ProliferationDose-Response Relationship, DrugFemaleHumansImmunologic FactorsIndonesiaLeukocytes, MononuclearMacrophagesMaleNitric OxidePhagocytosisPhyllanthusPlant ExtractsPlant LeavesPlants, MedicinalTuberculosis, Pulmonary

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28391709

Citation

Putri, Denise Utami, et al. "Immune Modulation Properties of Herbal Plant Leaves: Phyllanthus Niruri Aqueous Extract On Immune Cells of Tuberculosis Patient - in Vitro Study." Natural Product Research, vol. 32, no. 4, 2018, pp. 463-467.
Putri DU, Rintiswati N, Soesatyo MH, et al. Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study. Nat Prod Res. 2018;32(4):463-467.
Putri, D. U., Rintiswati, N., Soesatyo, M. H., & Haryana, S. M. (2018). Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study. Natural Product Research, 32(4), 463-467. https://doi.org/10.1080/14786419.2017.1311888
Putri DU, et al. Immune Modulation Properties of Herbal Plant Leaves: Phyllanthus Niruri Aqueous Extract On Immune Cells of Tuberculosis Patient - in Vitro Study. Nat Prod Res. 2018;32(4):463-467. PubMed PMID: 28391709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study. AU - Putri,Denise Utami, AU - Rintiswati,Ning, AU - Soesatyo,Marsetyawan Hne, AU - Haryana,Sofia Mubarika, Y1 - 2017/04/10/ PY - 2017/4/11/pubmed PY - 2018/3/20/medline PY - 2017/4/11/entrez KW - Phyllanthus niruri KW - Tuberculosis KW - herbal plant KW - immune modulation KW - phagocytic activity SP - 463 EP - 467 JF - Natural product research JO - Nat Prod Res VL - 32 IS - 4 N2 - Disease progression in Tuberculosis (TB) is dependent on host's immune system. Phyllanthus niruri, a traditional herb, has long been used to boost immune system in Indonesian society. This study aimed to observe the potential role of P. niruri in inducing immune cells activity in TB patients by in vitro approach. Peripheral blood mononuclear cells (PBMCs) and macrophages were collected from active pulmonary TB patients. After stimulation with graded doses of P. niruri aqueous extract, cell proliferation, phagocytic activity and nitric oxide (NO) release were analysed. P. niruri aqueous extract induced proliferation of PBMCs, increased NO release, and improved macrophages phagocytic activity. These effects were observed in a dose-dependent manner. This may lead to further research for the potential role of P. niruri as immunomodulatory adjuvant therapy for TB patients. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/28391709/Immune_modulation_properties_of_herbal_plant_leaves:_Phyllanthus_niruri_aqueous_extract_on_immune_cells_of_tuberculosis_patient___in_vitro_study_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2017.1311888 DB - PRIME DP - Unbound Medicine ER -