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Identification and in vitro antioxidant activities of phenolic compounds isolated from Cynoglossum cheirifolium L.
Nat Prod Res. 2018 Feb; 32(4):481-485.NP

Abstract

In an extensive search for bioactive compounds from plant sources, the quantitative and qualitative characterisation of the compounds present in Cynoglossum cheirifolium extracts was studied. Total phenolic and flavonoid contents were determined by spectrophotometric techniques. In vitro antioxidant and radical scavenging profiling was determined through DPPH[•] scavenging activity and Ferric reducing antioxidant power (FRAP). Our study showed that leaves produce more phenolic compounds, followed by flowering aerial part. The butanolic fraction obtained from leaves extract exhibited the highest total phenolics (78.65 ± 3.58 mg GAE/g DW) and flavonoids (22.15 ± 4.66 mg CE/g DW). In contrast, this fraction displayed the highest DPPH[•] scavenging ability with IC50 values of 0.06 ± 0.003 mg/mL. The RP-HPLC-PDA analysis of phenolic compounds from leaves of C. cheirifolium lets to identify: rosmarinic acid, ferulic acid, caffeic acid, p-coumaric acid, syringic acid, sinapic acid and rutin. The obtained results indicate that this plant represent a valuable source of natural antioxidants.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ilhem B
a Faculté SNV-STU, Laboratoire des Produits naturels, Département de Biologie , Université Aboubekr BELKAÏD Tlemcen , Imama , Algeria.
Fawzia AB
a Faculté SNV-STU, Laboratoire des Produits naturels, Département de Biologie , Université Aboubekr BELKAÏD Tlemcen , Imama , Algeria.
Imad Abdelhamid EH
b Centre de Recherche scientifique et technique en Analyses Physico-chimiques (CRAPC) , Bou-Ismail , Algeria.
Karima B
a Faculté SNV-STU, Laboratoire des Produits naturels, Département de Biologie , Université Aboubekr BELKAÏD Tlemcen , Imama , Algeria.
Fawzia B
c Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene USTHB , Bab-Ezzouar , Algeria.
Chahrazed B
a Faculté SNV-STU, Laboratoire des Produits naturels, Département de Biologie , Université Aboubekr BELKAÏD Tlemcen , Imama , Algeria.

MeSH

AntioxidantsBoraginaceaeChromatography, High Pressure LiquidCinnamatesDepsidesDrug Evaluation, PreclinicalFlavonoidsGallic AcidPhenolsPlant ExtractsPlant Leaves

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28391725

Citation

Ilhem, Bensaid, et al. "Identification and in Vitro Antioxidant Activities of Phenolic Compounds Isolated From Cynoglossum Cheirifolium L." Natural Product Research, vol. 32, no. 4, 2018, pp. 481-485.
Ilhem B, Fawzia AB, Imad Abdelhamid EH, et al. Identification and in vitro antioxidant activities of phenolic compounds isolated from Cynoglossum cheirifolium L. Nat Prod Res. 2018;32(4):481-485.
Ilhem, B., Fawzia, A. B., Imad Abdelhamid, E. H., Karima, B., Fawzia, B., & Chahrazed, B. (2018). Identification and in vitro antioxidant activities of phenolic compounds isolated from Cynoglossum cheirifolium L. Natural Product Research, 32(4), 481-485. https://doi.org/10.1080/14786419.2017.1314286
Ilhem B, et al. Identification and in Vitro Antioxidant Activities of Phenolic Compounds Isolated From Cynoglossum Cheirifolium L. Nat Prod Res. 2018;32(4):481-485. PubMed PMID: 28391725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification and in vitro antioxidant activities of phenolic compounds isolated from Cynoglossum cheirifolium L. AU - Ilhem,Bensaid, AU - Fawzia,Atik Bekkara, AU - Imad Abdelhamid,El Haci, AU - Karima,Belarbi, AU - Fawzia,Beddou, AU - Chahrazed,Bekhechi, Y1 - 2017/04/09/ PY - 2017/4/11/pubmed PY - 2018/3/20/medline PY - 2017/4/11/entrez KW - Cynoglossum cheirifolium L. KW - RP-HPLC-PDA KW - antioxidant activity KW - flavonoids KW - phenolics SP - 481 EP - 485 JF - Natural product research JO - Nat Prod Res VL - 32 IS - 4 N2 - In an extensive search for bioactive compounds from plant sources, the quantitative and qualitative characterisation of the compounds present in Cynoglossum cheirifolium extracts was studied. Total phenolic and flavonoid contents were determined by spectrophotometric techniques. In vitro antioxidant and radical scavenging profiling was determined through DPPH[•] scavenging activity and Ferric reducing antioxidant power (FRAP). Our study showed that leaves produce more phenolic compounds, followed by flowering aerial part. The butanolic fraction obtained from leaves extract exhibited the highest total phenolics (78.65 ± 3.58 mg GAE/g DW) and flavonoids (22.15 ± 4.66 mg CE/g DW). In contrast, this fraction displayed the highest DPPH[•] scavenging ability with IC50 values of 0.06 ± 0.003 mg/mL. The RP-HPLC-PDA analysis of phenolic compounds from leaves of C. cheirifolium lets to identify: rosmarinic acid, ferulic acid, caffeic acid, p-coumaric acid, syringic acid, sinapic acid and rutin. The obtained results indicate that this plant represent a valuable source of natural antioxidants. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/28391725/Identification_and_in_vitro_antioxidant_activities_of_phenolic_compounds_isolated_from_Cynoglossum_cheirifolium_L_ DB - PRIME DP - Unbound Medicine ER -