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Clinical evaluation of methylcellulose as a bulk laxative.
Dig Dis Sci. 1988 Aug; 33(8):993-8.DD

Abstract

We studied a bulk laxative containing methylcellulose in a group of normal subjects as well as in a group of chronically constipated individuals. The initial study in normal subjects was performed to show that the compound could increase fecal weight without significant side effects. Fifty healthy subjects were studied. Methylcellulose in daily doses of 4 g demonstrated a statistically significant increase in fecal frequency, fecal water, and fecal solids. In the second phase, we studied a group of 59 chronically constipated individuals treated with daily doses of the laxative containing either 1, 2, or 4 g of methylcellulose or 3.4 g psyllium. All of these doses resulted in statistically significant increases in stool frequency, water content, and fecal solids. There was no increase in individual stool weight from any of the laxative doses. Methylcellulose, in a daily dose as low as 1 g, is an effective laxative.

Authors+Show Affiliations

Department of Medicine, University of Wisconsin, Madison.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2839321

Citation

Hamilton, J W., et al. "Clinical Evaluation of Methylcellulose as a Bulk Laxative." Digestive Diseases and Sciences, vol. 33, no. 8, 1988, pp. 993-8.
Hamilton JW, Wagner J, Burdick BB, et al. Clinical evaluation of methylcellulose as a bulk laxative. Dig Dis Sci. 1988;33(8):993-8.
Hamilton, J. W., Wagner, J., Burdick, B. B., & Bass, P. (1988). Clinical evaluation of methylcellulose as a bulk laxative. Digestive Diseases and Sciences, 33(8), 993-8.
Hamilton JW, et al. Clinical Evaluation of Methylcellulose as a Bulk Laxative. Dig Dis Sci. 1988;33(8):993-8. PubMed PMID: 2839321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation of methylcellulose as a bulk laxative. AU - Hamilton,J W, AU - Wagner,J, AU - Burdick,B B, AU - Bass,P, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 993 EP - 8 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 33 IS - 8 N2 - We studied a bulk laxative containing methylcellulose in a group of normal subjects as well as in a group of chronically constipated individuals. The initial study in normal subjects was performed to show that the compound could increase fecal weight without significant side effects. Fifty healthy subjects were studied. Methylcellulose in daily doses of 4 g demonstrated a statistically significant increase in fecal frequency, fecal water, and fecal solids. In the second phase, we studied a group of 59 chronically constipated individuals treated with daily doses of the laxative containing either 1, 2, or 4 g of methylcellulose or 3.4 g psyllium. All of these doses resulted in statistically significant increases in stool frequency, water content, and fecal solids. There was no increase in individual stool weight from any of the laxative doses. Methylcellulose, in a daily dose as low as 1 g, is an effective laxative. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/2839321/Clinical_evaluation_of_methylcellulose_as_a_bulk_laxative_ L2 - https://medlineplus.gov/constipation.html DB - PRIME DP - Unbound Medicine ER -