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The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model.
Biomed Pharmacother. 2017 Jun; 90:500-508.BP

Abstract

OBJECTIVE

The aim of this study is to investigate the roles of SIRT1 and NF-κB in the pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the effects of hesperidin and quercetin on oxidative stress and on the levels of SIRT1 and NF-κB.

MATERIALS AND METHODS

The experimental animals were divided into four groups, each group comprising ten rats designated as follows: group 1 served as control rats (C); group 2 served as diabetic rats (DM); group 3 served as diabetic rats administered hesperidin (DM+HSP) (100mg/kg b.w.) in aqueous suspension orally for 15 days; and group 4 served as diabetic rats administered quercetin (DM+Q) (100mg/kg b.w.) in aqueous suspension orally for 15 days.

RESULTS

In diabetic group, liver and kidney SIRT1, SOD and CAT activities were significantly lower than control group (p<0.05). Hesperidin and quercetin caused significant increase in the SIRT1, SOD and CAT activities of both DM+HP and DM+Q groups kidney tissues compared to DM group (p<0.05). Liver SOD activies were not found to differ significantly between DM, DM+Q and DM+HP groups (p>0.05). In DM+HP group, liver CAT activities were significantly higher than DM (p<0.05), but there was no significant difference in liver CAT activities between DM and DM+Q (p>0.05). In diabetic group, liver and kidney NF-κB and MDA levels were increased compared to control group (p<0.05), and groups of DM+HP and DM+Q had lower NF-κB and MDA levels than diabetic group (p<0.05).

CONCLUSION

As a conclusion, based on the results we obtained from this study and the literature data discussed above, we determined in STZ-induced diabetic rats that, increased glucose levels and liver and kidney damage markers decreased significantly after administration of hesperedin and quercetin, and that oxidative stress and NF-κB levels increased while SIRT1 levels decreased in the diabetic group.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin 08000, Turkey. Electronic address: haticeiskender2011@hotmail.com.Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin 08000, Turkey. Electronic address: edadokumacioglu@yahoo.com.Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Teknik University, Trabzon 61000, Turkey. Electronic address: tugba.mazlum@hotmail.com.Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Teknik University, Trabzon 61000, Turkey. Electronic address: narmince@hotmail.com.Department of Nursing, Faculty of Health Sciences, Artvin Coruh University, Artvin 08000, Turkey. Electronic address: yalcinkanbay@artvin.edu.tr.Guneysu Vocational School of Physical Therapy and Rehabilitation, Recep Tayyip Erdogan University, Rize 53000, Turkey. Electronic address: sinansaral61@msn.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28395272

Citation

Iskender, Hatice, et al. "The Effect of Hesperidin and Quercetin On Oxidative Stress, NF-κB and SIRT1 Levels in a STZ-induced Experimental Diabetes Model." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 90, 2017, pp. 500-508.
Iskender H, Dokumacioglu E, Sen TM, et al. The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model. Biomed Pharmacother. 2017;90:500-508.
Iskender, H., Dokumacioglu, E., Sen, T. M., Ince, I., Kanbay, Y., & Saral, S. (2017). The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 90, 500-508. https://doi.org/10.1016/j.biopha.2017.03.102
Iskender H, et al. The Effect of Hesperidin and Quercetin On Oxidative Stress, NF-κB and SIRT1 Levels in a STZ-induced Experimental Diabetes Model. Biomed Pharmacother. 2017;90:500-508. PubMed PMID: 28395272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model. AU - Iskender,Hatice, AU - Dokumacioglu,Eda, AU - Sen,Tugba Mazlum, AU - Ince,Imran, AU - Kanbay,Yalcin, AU - Saral,Sinan, Y1 - 2017/04/07/ PY - 2017/02/16/received PY - 2017/4/11/pubmed PY - 2018/2/24/medline PY - 2017/4/11/entrez KW - Diabetes KW - Hesperidin KW - NF-κB KW - Oxidative stress KW - Quercetin KW - Sirtuin-1 SP - 500 EP - 508 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 90 N2 - OBJECTIVE: The aim of this study is to investigate the roles of SIRT1 and NF-κB in the pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the effects of hesperidin and quercetin on oxidative stress and on the levels of SIRT1 and NF-κB. MATERIALS AND METHODS: The experimental animals were divided into four groups, each group comprising ten rats designated as follows: group 1 served as control rats (C); group 2 served as diabetic rats (DM); group 3 served as diabetic rats administered hesperidin (DM+HSP) (100mg/kg b.w.) in aqueous suspension orally for 15 days; and group 4 served as diabetic rats administered quercetin (DM+Q) (100mg/kg b.w.) in aqueous suspension orally for 15 days. RESULTS: In diabetic group, liver and kidney SIRT1, SOD and CAT activities were significantly lower than control group (p<0.05). Hesperidin and quercetin caused significant increase in the SIRT1, SOD and CAT activities of both DM+HP and DM+Q groups kidney tissues compared to DM group (p<0.05). Liver SOD activies were not found to differ significantly between DM, DM+Q and DM+HP groups (p>0.05). In DM+HP group, liver CAT activities were significantly higher than DM (p<0.05), but there was no significant difference in liver CAT activities between DM and DM+Q (p>0.05). In diabetic group, liver and kidney NF-κB and MDA levels were increased compared to control group (p<0.05), and groups of DM+HP and DM+Q had lower NF-κB and MDA levels than diabetic group (p<0.05). CONCLUSION: As a conclusion, based on the results we obtained from this study and the literature data discussed above, we determined in STZ-induced diabetic rats that, increased glucose levels and liver and kidney damage markers decreased significantly after administration of hesperedin and quercetin, and that oxidative stress and NF-κB levels increased while SIRT1 levels decreased in the diabetic group. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/28395272/The_effect_of_hesperidin_and_quercetin_on_oxidative_stress_NF_κB_and_SIRT1_levels_in_a_STZ_induced_experimental_diabetes_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)30735-7 DB - PRIME DP - Unbound Medicine ER -