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Molecular Mechanisms Leading to Splanchnic Vasodilation in Liver Cirrhosis.
J Vasc Res. 2017; 54(2):92-99.JV

Abstract

In liver cirrhosis, portal hypertension is a consequence of enhanced intrahepatic vascular resistance and portal blood flow. Significant vasodilation in the arterial splanchnic district is crucial for an increase in portal flow. In this pathological condition, increased levels of circulating endogenous vasodilators, including nitric oxide, prostacyclin, carbon monoxide, epoxyeicosatrienoic acids, glucagon, endogenous cannabinoids, and adrenomedullin, and a decreased vascular response to vasoconstrictors are the main mechanisms underlying splanchnic vasodilation. In this review, the molecular pathways leading to splanchnic vasodilation will be discussed in detail.

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Authors+Show Affiliations

Di Pascoli M
Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padua, Italy.
Sacerdoti D
No affiliation info available
Pontisso P
No affiliation info available
Angeli P
No affiliation info available
Bolognesi M
No affiliation info available

MeSH

AnimalsArteriesHumansHypertension, PortalLiver CirrhosisPortal PressureSignal TransductionSplanchnic CirculationVasoconstrictionVasodilation

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28402977

Citation

Di Pascoli, Marco, et al. "Molecular Mechanisms Leading to Splanchnic Vasodilation in Liver Cirrhosis." Journal of Vascular Research, vol. 54, no. 2, 2017, pp. 92-99.
Di Pascoli M, Sacerdoti D, Pontisso P, et al. Molecular Mechanisms Leading to Splanchnic Vasodilation in Liver Cirrhosis. J Vasc Res. 2017;54(2):92-99.
Di Pascoli, M., Sacerdoti, D., Pontisso, P., Angeli, P., & Bolognesi, M. (2017). Molecular Mechanisms Leading to Splanchnic Vasodilation in Liver Cirrhosis. Journal of Vascular Research, 54(2), 92-99. https://doi.org/10.1159/000462974
Di Pascoli M, et al. Molecular Mechanisms Leading to Splanchnic Vasodilation in Liver Cirrhosis. J Vasc Res. 2017;54(2):92-99. PubMed PMID: 28402977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular Mechanisms Leading to Splanchnic Vasodilation in Liver Cirrhosis. AU - Di Pascoli,Marco, AU - Sacerdoti,David, AU - Pontisso,Patrizia, AU - Angeli,Paolo, AU - Bolognesi,Massimo, Y1 - 2017/04/13/ PY - 2016/12/12/received PY - 2017/02/06/accepted PY - 2017/4/14/pubmed PY - 2017/6/20/medline PY - 2017/4/14/entrez KW - Liver KW - Liver cirrhosis KW - Splanchnic vasodilation KW - Vascular tone KW - Vasoactive molecules SP - 92 EP - 99 JF - Journal of vascular research JO - J Vasc Res VL - 54 IS - 2 N2 - In liver cirrhosis, portal hypertension is a consequence of enhanced intrahepatic vascular resistance and portal blood flow. Significant vasodilation in the arterial splanchnic district is crucial for an increase in portal flow. In this pathological condition, increased levels of circulating endogenous vasodilators, including nitric oxide, prostacyclin, carbon monoxide, epoxyeicosatrienoic acids, glucagon, endogenous cannabinoids, and adrenomedullin, and a decreased vascular response to vasoconstrictors are the main mechanisms underlying splanchnic vasodilation. In this review, the molecular pathways leading to splanchnic vasodilation will be discussed in detail. SN - 1423-0135 UR - https://www.unboundmedicine.com/medline/citation/28402977/Molecular_Mechanisms_Leading_to_Splanchnic_Vasodilation_in_Liver_Cirrhosis_ L2 - https://www.karger.com?DOI=10.1159/000462974 DB - PRIME DP - Unbound Medicine ER -