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Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis.
PLoS One 2017; 12(4):e0175565Plos

Abstract

OBJECTIVES

This study aimed to (1) compare outcome assessments in normal and osteoarthritic cats and (2) evaluate the analgesic efficacy of tramadol in feline osteoarthritis (OA), in a prospective, randomised, blinded, placebo-controlled, crossover design.

METHODS

Twenty cats were included after clinical examination, blood work and full body radiographs were performed. In Phase 1, outcome assessments aimed to differentiate normal (n = 5; i.e. exempt of any radiographic and clinical sign of OA) from OA (n = 15) cats. In Phase 2, OA cats were treated twice daily with a placebo (PG: cornstarch 15 mg) or tramadol (TG: 3 mg/kg) orally for 19 days, with a 3-month washout period between treatments. Evaluations were performed in normal and OA cats at baseline and consisted of: 1) peak vertical force (PVF) after staircase exercise; 2) telemetered night-time motor activity (NMA); and 3) response to mechanical temporal summation (RMTS). After treatment, PVF, NMA and RMTS evaluations were repeated in OA cats. Data were analysed with mixed model methods with an alpha-threshold of 5%.

RESULTS

Phase 1: 1) PVF (% of body weight; mean ± SD) was higher in normal (59 ± 10.5) than in OA cats (50.6 ± 5.7) (p = 0.005); 2) NMA (no unit) was not different between groups; 3) RMTS (number of stimuli; median (range)) was higher in normal [29.5 (23.5-30)] than in OA cats [14 (8.5-28)] (p < 0.0001). Phase 2: PVF, NMA and RMTS presented a treatment effect (p = 0.024, p = 0.008 and p = 0.018, respectively). No clinically important adverse-effects were observed.

CONCLUSION

Outcome assessments such as kinetics (PVF) and evaluation of central sensitisation (RMTS) are discriminant of OA status. Mobility measured by NMA was not discriminant of OA status, however it increased in OA cats with tramadol treatment. Nociceptive hypersensitivity quantified by RMTS was evident in OA cats and was responsive to tramadol treatment.

Authors+Show Affiliations

GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada.GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.Department of Clinical Sciences, Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada.Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada.GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada.GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine-Université de Montréal, Saint-Hyacinthe, QC, Canada. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28403198

Citation

Monteiro, Beatriz P., et al. "Analgesic Efficacy of Tramadol in Cats With Naturally Occurring Osteoarthritis." PloS One, vol. 12, no. 4, 2017, pp. e0175565.
Monteiro BP, Klinck MP, Moreau M, et al. Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis. PLoS ONE. 2017;12(4):e0175565.
Monteiro, B. P., Klinck, M. P., Moreau, M., Guillot, M., Steagall, P. V., Pelletier, J. P., ... Troncy, E. (2017). Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis. PloS One, 12(4), pp. e0175565. doi:10.1371/journal.pone.0175565.
Monteiro BP, et al. Analgesic Efficacy of Tramadol in Cats With Naturally Occurring Osteoarthritis. PLoS ONE. 2017;12(4):e0175565. PubMed PMID: 28403198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis. AU - Monteiro,Beatriz P, AU - Klinck,Mary P, AU - Moreau,Maxim, AU - Guillot,Martin, AU - Steagall,Paulo V M, AU - Pelletier,Jean-Pierre, AU - Martel-Pelletier,Johanne, AU - Gauvin,Dominique, AU - Del Castillo,Jérôme R E, AU - Troncy,Eric, Y1 - 2017/04/12/ PY - 2016/10/24/received PY - 2017/03/28/accepted PY - 2017/4/14/entrez PY - 2017/4/14/pubmed PY - 2017/4/22/medline SP - e0175565 EP - e0175565 JF - PloS one JO - PLoS ONE VL - 12 IS - 4 N2 - OBJECTIVES: This study aimed to (1) compare outcome assessments in normal and osteoarthritic cats and (2) evaluate the analgesic efficacy of tramadol in feline osteoarthritis (OA), in a prospective, randomised, blinded, placebo-controlled, crossover design. METHODS: Twenty cats were included after clinical examination, blood work and full body radiographs were performed. In Phase 1, outcome assessments aimed to differentiate normal (n = 5; i.e. exempt of any radiographic and clinical sign of OA) from OA (n = 15) cats. In Phase 2, OA cats were treated twice daily with a placebo (PG: cornstarch 15 mg) or tramadol (TG: 3 mg/kg) orally for 19 days, with a 3-month washout period between treatments. Evaluations were performed in normal and OA cats at baseline and consisted of: 1) peak vertical force (PVF) after staircase exercise; 2) telemetered night-time motor activity (NMA); and 3) response to mechanical temporal summation (RMTS). After treatment, PVF, NMA and RMTS evaluations were repeated in OA cats. Data were analysed with mixed model methods with an alpha-threshold of 5%. RESULTS: Phase 1: 1) PVF (% of body weight; mean ± SD) was higher in normal (59 ± 10.5) than in OA cats (50.6 ± 5.7) (p = 0.005); 2) NMA (no unit) was not different between groups; 3) RMTS (number of stimuli; median (range)) was higher in normal [29.5 (23.5-30)] than in OA cats [14 (8.5-28)] (p < 0.0001). Phase 2: PVF, NMA and RMTS presented a treatment effect (p = 0.024, p = 0.008 and p = 0.018, respectively). No clinically important adverse-effects were observed. CONCLUSION: Outcome assessments such as kinetics (PVF) and evaluation of central sensitisation (RMTS) are discriminant of OA status. Mobility measured by NMA was not discriminant of OA status, however it increased in OA cats with tramadol treatment. Nociceptive hypersensitivity quantified by RMTS was evident in OA cats and was responsive to tramadol treatment. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/28403198/Analgesic_efficacy_of_tramadol_in_cats_with_naturally_occurring_osteoarthritis_ L2 - http://dx.plos.org/10.1371/journal.pone.0175565 DB - PRIME DP - Unbound Medicine ER -