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Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment.
Nat Prod Res. 2017 Jul; 31(14):1669-1675.NP

Abstract

Two new cytochalasan derivatives, isochaetoglobosin Db (1) and cytoglobosin Ab (2), were isolated from an ethyl acetate extract of Chaetomium globosum SNSHI-5, a fungus derived from extreme environment. The structures of the new compounds were comprehensively characterized by HR-ESI-MS, 1H NMR, 13C NMR and 2D-NMR. Cytotoxic activity against H292 human lung cancer cell of the new compounds was tested. Isochaetoglobosin Db (1) showed potent cytotoxicity with IC50 of 3.5 μM, while cytoglobosin Ab was inactive (IC50 > 10 μM).

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Authors+Show Affiliations

Wang XY
a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Shenyang , China.
Yan X
b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
Fang MJ
b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
Wu Z
b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
Wang D
a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Shenyang , China. c China Democratic League , Chinese Shenyang Municipal Committee of Democratic League , Shenyang , China.
Qiu YK
b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorChaetomiumCytochalasinsExtreme EnvironmentsHumansMagnetic Resonance SpectroscopyMolecular Structure

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28403641

Citation

Wang, Xiao-Yan, et al. "Two New Cytochalasan Derivatives From Chaetomium Globosum SNSHI-5, a Fungus Derived From Extreme Environment." Natural Product Research, vol. 31, no. 14, 2017, pp. 1669-1675.
Wang XY, Yan X, Fang MJ, et al. Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment. Nat Prod Res. 2017;31(14):1669-1675.
Wang, X. Y., Yan, X., Fang, M. J., Wu, Z., Wang, D., & Qiu, Y. K. (2017). Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment. Natural Product Research, 31(14), 1669-1675. https://doi.org/10.1080/14786419.2017.1286478
Wang XY, et al. Two New Cytochalasan Derivatives From Chaetomium Globosum SNSHI-5, a Fungus Derived From Extreme Environment. Nat Prod Res. 2017;31(14):1669-1675. PubMed PMID: 28403641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment. AU - Wang,Xiao-Yan, AU - Yan,Xia, AU - Fang,Mei-Juan, AU - Wu,Zhen, AU - Wang,Dong, AU - Qiu,Ying-Kun, Y1 - 2017/04/12/ PY - 2017/4/14/pubmed PY - 2017/9/25/medline PY - 2017/4/14/entrez KW - Chaetomium globosum SNSHI-5 KW - cytochalasan derivatives KW - cytoglobosin Ab KW - cytotoxic activity KW - isochaetoglobosin Db SP - 1669 EP - 1675 JF - Natural product research JO - Nat Prod Res VL - 31 IS - 14 N2 - Two new cytochalasan derivatives, isochaetoglobosin Db (1) and cytoglobosin Ab (2), were isolated from an ethyl acetate extract of Chaetomium globosum SNSHI-5, a fungus derived from extreme environment. The structures of the new compounds were comprehensively characterized by HR-ESI-MS, 1H NMR, 13C NMR and 2D-NMR. Cytotoxic activity against H292 human lung cancer cell of the new compounds was tested. Isochaetoglobosin Db (1) showed potent cytotoxicity with IC50 of 3.5 μM, while cytoglobosin Ab was inactive (IC50 > 10 μM). SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/28403641/Two_new_cytochalasan_derivatives_from_Chaetomium_globosum_SNSHI_5_a_fungus_derived_from_extreme_environment_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2017.1286478 DB - PRIME DP - Unbound Medicine ER -