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Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis.
J Dermatol. 2017 Aug; 44(8):920-926.JD

Abstract

Stress-induced scratching is an issue in patients with adult atopic dermatitis (AD). Although itching and stress are believed to be intimately related, no objective index is available; therefore, most evaluations are subjective. Using saliva, which is easily collected, we investigated the degree to which AD severity and patient stress levels are reflected in stress proteins in the saliva. Here, we evaluated the severity (Scoring Atopic Dermatitis [SCORAD] score), stress (State-Trait Anxiety Index [STAI] score), personality (Tokyo University Egogram [TEG] II score) and quality of life (Dermatology Life Quality Index [DLQI] score) of 51 patients with AD who were examined in the Department of Dermatology of Shimane University between April and December 2015. We collected saliva and measured salivary chromogranin A (CgA), amylase and cortisol. The amount of salivary CgA per protein in patients with AD was correlated with their SCORAD score (r = 0.458, P < 0.001). There was no correlation between cortisol or amylase levels and SCORAD score. SCORAD score was correlated with DLQI (r = 0.390, P = 0.006). CgA per protein was correlated with DLQI (r = 0.393, P = 0.004). There was no correlation between scores for the anxiety component of the STAI, TEG II or DLQI. Our results suggested that patients with more severe AD may have high stress levels. The personalities of these patients with AD tended to involve elevated anxiety levels.

Authors+Show Affiliations

Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.Department of Hygiene and Preventive Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

28406540

Citation

Kaneko, Sakae, et al. "Salivary Chromogranin a Levels Correlate With Disease Severity but Do Not Reflect Anxiety or Personality of Adult Patients With Atopic Dermatitis." The Journal of Dermatology, vol. 44, no. 8, 2017, pp. 920-926.
Kaneko S, Liu L, Kakamu T, et al. Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis. J Dermatol. 2017;44(8):920-926.
Kaneko, S., Liu, L., Kakamu, T., Minami-Hori, M., & Morita, E. (2017). Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis. The Journal of Dermatology, 44(8), 920-926. https://doi.org/10.1111/1346-8138.13852
Kaneko S, et al. Salivary Chromogranin a Levels Correlate With Disease Severity but Do Not Reflect Anxiety or Personality of Adult Patients With Atopic Dermatitis. J Dermatol. 2017;44(8):920-926. PubMed PMID: 28406540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis. AU - Kaneko,Sakae, AU - Liu,Lijuan, AU - Kakamu,Takeyasu, AU - Minami-Hori,Masako, AU - Morita,Eishin, Y1 - 2017/04/13/ PY - 2016/10/28/received PY - 2017/02/22/accepted PY - 2017/4/14/pubmed PY - 2018/5/1/medline PY - 2017/4/14/entrez KW - atopic KW - chromogranin A KW - dermatitis KW - saliva KW - stress marker SP - 920 EP - 926 JF - The Journal of dermatology JO - J. Dermatol. VL - 44 IS - 8 N2 - Stress-induced scratching is an issue in patients with adult atopic dermatitis (AD). Although itching and stress are believed to be intimately related, no objective index is available; therefore, most evaluations are subjective. Using saliva, which is easily collected, we investigated the degree to which AD severity and patient stress levels are reflected in stress proteins in the saliva. Here, we evaluated the severity (Scoring Atopic Dermatitis [SCORAD] score), stress (State-Trait Anxiety Index [STAI] score), personality (Tokyo University Egogram [TEG] II score) and quality of life (Dermatology Life Quality Index [DLQI] score) of 51 patients with AD who were examined in the Department of Dermatology of Shimane University between April and December 2015. We collected saliva and measured salivary chromogranin A (CgA), amylase and cortisol. The amount of salivary CgA per protein in patients with AD was correlated with their SCORAD score (r = 0.458, P < 0.001). There was no correlation between cortisol or amylase levels and SCORAD score. SCORAD score was correlated with DLQI (r = 0.390, P = 0.006). CgA per protein was correlated with DLQI (r = 0.393, P = 0.004). There was no correlation between scores for the anxiety component of the STAI, TEG II or DLQI. Our results suggested that patients with more severe AD may have high stress levels. The personalities of these patients with AD tended to involve elevated anxiety levels. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/28406540/Salivary_chromogranin_A_levels_correlate_with_disease_severity_but_do_not_reflect_anxiety_or_personality_of_adult_patients_with_atopic_dermatitis_ L2 - https://doi.org/10.1111/1346-8138.13852 DB - PRIME DP - Unbound Medicine ER -