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Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone by Aedes aegypti (Diptera: Culicidae), a Vector of Zika Virus.
J Med Entomol. 2017 07 01; 54(4):957-963.JM

Abstract

Nepeta essential oil (Neo; catnip) and its major component, nepetalactone, have long been known to repel insects including mosquitoes. However, the neural mechanisms through which these repellents are detected by mosquitoes, including the yellow fever mosquito Aedes aegypti (L.), an important vector of Zika virus, were poorly understood. Here we show that Neo volatiles activate olfactory receptor neurons within the basiconic sensilla on the maxillary palps of female Ae. aegypti. A gustatory receptor neuron sensitive to the feeding deterrent quinine and housed within sensilla on the labella of females was activated by both Neo and nepetalactone. Activity of a second gustatory receptor neuron sensitive to the feeding stimulant sucrose was suppressed by both repellents. Our results provide neural pathways for the reported spatial repellency and feeding deterrence of these repellents. A better understanding of the neural input through which female mosquitoes make decisions to feed will facilitate design of new repellents and management strategies involving their use.

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Authors+Show Affiliations

Sparks JT
United States Department of Agriculture, Agricultural Research Service, Henry A. Wallace Beltsville Agricultural Research Center, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, MD. Department of Biology, High Point University, High Point, NC.
Bohbot JD
United States Department of Agriculture, Agricultural Research Service, Henry A. Wallace Beltsville Agricultural Research Center, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, MD. Department of Entomology, The Hebrew University of Jerusalem, Rehovot, Israel.
Ristic M
Institute for Medicinal Plants Research "Dr Josif Pancic," University of Belgrade, Tadeuša Košcuška 1, 11000 Belgrade, Serbia.
Mišic D
Institute for Biological Research "Siniša Stankovic," University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
Skoric M
Institute for Biological Research "Siniša Stankovic," University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
Mattoo A
United States Department of Agriculture, Agricultural Research Service, Henry A. Wallace Beltsville Agricultural Research Center, Sustainable Agricultural Systems Laboratory, Beltsville, MD.
Dickens JC
United States Department of Agriculture, Agricultural Research Service, Henry A. Wallace Beltsville Agricultural Research Center, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, MD.

MeSH

AedesAnimalsCyclopentane MonoterpenesCyclopentanesFemaleInsect RepellentsMaxillaNepetaOils, VolatileOlfactory Receptor NeuronsPyronesSensilla

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28407077

Citation

Sparks, Jackson T., et al. "Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone By Aedes Aegypti (Diptera: Culicidae), a Vector of Zika Virus." Journal of Medical Entomology, vol. 54, no. 4, 2017, pp. 957-963.
Sparks JT, Bohbot JD, Ristic M, et al. Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone by Aedes aegypti (Diptera: Culicidae), a Vector of Zika Virus. J Med Entomol. 2017;54(4):957-963.
Sparks, J. T., Bohbot, J. D., Ristic, M., Mišic, D., Skoric, M., Mattoo, A., & Dickens, J. C. (2017). Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone by Aedes aegypti (Diptera: Culicidae), a Vector of Zika Virus. Journal of Medical Entomology, 54(4), 957-963. https://doi.org/10.1093/jme/tjx059
Sparks JT, et al. Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone By Aedes Aegypti (Diptera: Culicidae), a Vector of Zika Virus. J Med Entomol. 2017 07 1;54(4):957-963. PubMed PMID: 28407077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone by Aedes aegypti (Diptera: Culicidae), a Vector of Zika Virus. AU - Sparks,Jackson T, AU - Bohbot,Jonathan D, AU - Ristic,Mihailo, AU - Mišic,Danijela, AU - Skoric,Marijana, AU - Mattoo,Autar, AU - Dickens,Joseph C, PY - 2016/08/31/received PY - 2017/4/14/pubmed PY - 2017/10/14/medline PY - 2017/4/14/entrez KW - Nepeta KW - catnip KW - mosquito KW - olfaction KW - taste SP - 957 EP - 963 JF - Journal of medical entomology JO - J Med Entomol VL - 54 IS - 4 N2 - Nepeta essential oil (Neo; catnip) and its major component, nepetalactone, have long been known to repel insects including mosquitoes. However, the neural mechanisms through which these repellents are detected by mosquitoes, including the yellow fever mosquito Aedes aegypti (L.), an important vector of Zika virus, were poorly understood. Here we show that Neo volatiles activate olfactory receptor neurons within the basiconic sensilla on the maxillary palps of female Ae. aegypti. A gustatory receptor neuron sensitive to the feeding deterrent quinine and housed within sensilla on the labella of females was activated by both Neo and nepetalactone. Activity of a second gustatory receptor neuron sensitive to the feeding stimulant sucrose was suppressed by both repellents. Our results provide neural pathways for the reported spatial repellency and feeding deterrence of these repellents. A better understanding of the neural input through which female mosquitoes make decisions to feed will facilitate design of new repellents and management strategies involving their use. SN - 1938-2928 UR - https://www.unboundmedicine.com/medline/citation/28407077/Chemosensory_Responses_to_the_Repellent_Nepeta_Essential_Oil_and_Its_Major_Component_Nepetalactone_by_Aedes_aegypti__Diptera:_Culicidae__a_Vector_of_Zika_Virus_ DB - PRIME DP - Unbound Medicine ER -