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The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome.
Exp Clin Endocrinol Diabetes. 2017 May; 125(5):316-321.EC

Abstract

Data on the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles among vitamin D-deficient women with polycystic ovary syndrome (PCOS) are scarce. This study was done to determine the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with PCOS. This randomized double-blind, placebo-controlled trial was conducted among 55 vitamin D-deficient women diagnosed with PCOS aged 18-40 years old. Subjects were randomly assigned into 2 groups to intake either 500 mg calcium, 200 IU vitamin D and 90 µg vitamin K supplements (n=28) or placebo (n=27) twice a day for 8 weeks. After the 8-week intervention, compared with the placebo, joint calcium, vitamins D and K supplementation resulted in significant decreases in serum insulin concentrations (-1.9±3.5 vs. +1.8±6.6 µIU/mL, P=0.01), homeostasis model of assessment-estimated insulin resistance (-0.4±0.7 vs. +0.4±1.4, P=0.01), homeostasis model of assessment-estimated b cell function (-7.9±14.7 vs. +7.0±30.3, P=0.02) and a significant increase in quantitative insulin sensitivity check index (+0.01±0.01 vs. -0.008±0.03, P=0.01). In addition, significant decreases in serum triglycerides (-23.4±71.3 vs. +9.9±39.5 mg/dL, P=0.03) and VLDL-cholesterol levels (-4.7±14.3 vs. +2.0±7.9 mg/dL, P=0.03) was observed following supplementation with combined calcium, vitamins D and K compared with the placebo. Overall, calcium, vitamins D and K co-supplementation for 8 weeks among vitamin D-deficient women with PCOS had beneficial effects on markers of insulin metabolism, serum triglycerides and VLDL-cholesterol levels.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Karamali M
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ashrafi M
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Razavi M
Department of Gynecology and Obstetrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Jamilian M
Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Akbari M
Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Asemi Z
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.

MeSH

AdolescentAdultCalciumFemaleHumansLipidsPolycystic Ovary SyndromeVitamin DVitamin D DeficiencyVitamin K

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28407660

Citation

Karamali, Maryam, et al. "The Effects of Calcium, Vitamins D and K co-Supplementation On Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women With Polycystic Ovary Syndrome." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 125, no. 5, 2017, pp. 316-321.
Karamali M, Ashrafi M, Razavi M, et al. The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome. Exp Clin Endocrinol Diabetes. 2017;125(5):316-321.
Karamali, M., Ashrafi, M., Razavi, M., Jamilian, M., Akbari, M., & Asemi, Z. (2017). The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 125(5), 316-321. https://doi.org/10.1055/s-0043-104530
Karamali M, et al. The Effects of Calcium, Vitamins D and K co-Supplementation On Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women With Polycystic Ovary Syndrome. Exp Clin Endocrinol Diabetes. 2017;125(5):316-321. PubMed PMID: 28407660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome. AU - Karamali,Maryam, AU - Ashrafi,Mahnaz, AU - Razavi,Maryamalsadat, AU - Jamilian,Mehri, AU - Akbari,Maryam, AU - Asemi,Zatollah, Y1 - 2017/04/13/ PY - 2017/4/14/pubmed PY - 2018/3/10/medline PY - 2017/4/14/entrez SP - 316 EP - 321 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 125 IS - 5 N2 - Data on the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles among vitamin D-deficient women with polycystic ovary syndrome (PCOS) are scarce. This study was done to determine the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with PCOS. This randomized double-blind, placebo-controlled trial was conducted among 55 vitamin D-deficient women diagnosed with PCOS aged 18-40 years old. Subjects were randomly assigned into 2 groups to intake either 500 mg calcium, 200 IU vitamin D and 90 µg vitamin K supplements (n=28) or placebo (n=27) twice a day for 8 weeks. After the 8-week intervention, compared with the placebo, joint calcium, vitamins D and K supplementation resulted in significant decreases in serum insulin concentrations (-1.9±3.5 vs. +1.8±6.6 µIU/mL, P=0.01), homeostasis model of assessment-estimated insulin resistance (-0.4±0.7 vs. +0.4±1.4, P=0.01), homeostasis model of assessment-estimated b cell function (-7.9±14.7 vs. +7.0±30.3, P=0.02) and a significant increase in quantitative insulin sensitivity check index (+0.01±0.01 vs. -0.008±0.03, P=0.01). In addition, significant decreases in serum triglycerides (-23.4±71.3 vs. +9.9±39.5 mg/dL, P=0.03) and VLDL-cholesterol levels (-4.7±14.3 vs. +2.0±7.9 mg/dL, P=0.03) was observed following supplementation with combined calcium, vitamins D and K compared with the placebo. Overall, calcium, vitamins D and K co-supplementation for 8 weeks among vitamin D-deficient women with PCOS had beneficial effects on markers of insulin metabolism, serum triglycerides and VLDL-cholesterol levels. SN - 1439-3646 UR - https://www.unboundmedicine.com/medline/citation/28407660/The_Effects_of_Calcium_Vitamins_D_and_K_co_Supplementation_on_Markers_of_Insulin_Metabolism_and_Lipid_Profiles_in_Vitamin_D_Deficient_Women_with_Polycystic_Ovary_Syndrome_ DB - PRIME DP - Unbound Medicine ER -