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The antibacterial agent, moxifloxacin inhibits virulence factors of Candida albicans through multitargeting.

Abstract

Fluoroquinolines are broad spectrum fourth generation antibiotics. Some of the Fluoroquinolines exhibit antifungal activity. We are reporting the potential mechanism of action of a fluoroquinoline antibiotic, moxifloxacin on the growth, morphogenesis and biofilm formation of the human pathogen Candida albicans. Moxifloxacin was found to be Candidacidal in nature. Moxifloxacin seems to inhibit the yeast to Hyphal morphogenesis by affecting signaling pathways. It arrested the cell cycle of C. albicans at S phase. Docking of moxifloxacin with predicted structure of C. albicans DNA Topoisomerase II suggests that moxifloxacin may bind and inhibit the activity of DNA Topoisomerase II in C. albicans. Moxifloxacin could be used as a dual purpose antibiotic for treating mixed infections caused by bacteria as well as C. albicans. In addition chances of developing moxifloxacin resistance in C. albicans are less considering the fact that moxifloxacin may target multiple steps in yeast to hyphal transition in C. albicans.

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  • Authors+Show Affiliations

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    School of Life Sciences (DST-FIST & UGC-SAP Sponsored), SRTM University (NAAC Accredited with 'A' Grade), Nanded, Maharashtra, 431606, India.

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    School of Life Sciences (DST-FIST & UGC-SAP Sponsored), SRTM University (NAAC Accredited with 'A' Grade), Nanded, Maharashtra, 431606, India.

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    School of Life Sciences (DST-FIST & UGC-SAP Sponsored), SRTM University (NAAC Accredited with 'A' Grade), Nanded, Maharashtra, 431606, India.

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    Department of Biotechnology, Savitribai Phule Pune Univesity, Ganeshkhind, Pune, Maharashtra, 411007, India.

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    Department of Biotechnology, Savitribai Phule Pune Univesity, Ganeshkhind, Pune, Maharashtra, 411007, India.

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    Department of Biotechnology, Savitribai Phule Pune Univesity, Ganeshkhind, Pune, Maharashtra, 411007, India.

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    Department of Biotechnology, Deogiri College Aurangabad, Aurangabad, Maharashtra, India.

    School of Life Sciences (DST-FIST & UGC-SAP Sponsored), SRTM University (NAAC Accredited with 'A' Grade), Nanded, Maharashtra, 431606, India. prof.karuppayil@gmail.com.

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    MeSH

    Antifungal Agents
    Candida albicans
    Cell Cycle
    DNA Topoisomerases, Type II
    Fluoroquinolones
    Fungal Proteins
    Gene Expression Regulation, Fungal
    Hyphae
    Microbial Sensitivity Tests
    Models, Molecular
    Molecular Docking Simulation
    Virulence
    Virulence Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28409362