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Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes.
Biol Trace Elem Res 2017; 180(2):246-254BT

Abstract

For the increasing development of diabetes, dietary habits and using appropriate supplements can play important roles in the treatment or reduction of risk for this disease. The objective of this study was to investigate the effects of leucine (Leu), zinc (Zn), and chromium (Cr) supplementation, alone or in combination, in rats with type 2 diabetes (T2D). Seventy-seven adult male Wistar rats were randomly assigned in 11 groups, using nutritional supplements and insulin (INS) or glibenclamide (GLC). Supplementing Leu significantly reduced blood glucose, triglycerides (TG), nonesterified fatty acids (NEFA), low-density lipoprotein (LDL), and increased high-density lipoprotein (HDL) concentrations compared to vehicle-treated T2D animals, and those improvements were associated with reduced area under the 2-h blood glucose response curve (AUC). Supplementation of T2D animals with Zn improved serum lipid profile as well as blood glucose concentrations but was not comparable with the INS, GLC, and Leu groups. Supplementary Cr did not improve blood glucose and AUC in T2D rats, whereas it reduced serum TG and LDL and increased HDL concentrations. In conclusion, supplementation of diabetic rats with Leu was more effective in improving blood glucose and consequently decreasing glucose AUC than other nutritional supplements. Supplementary Zn and Cr only improved serum lipid profile. The combination of the nutritional supplements did not improve blood glucose level. Nevertheless, supplementation with Leu-Zn, Leu-Cr, Zn-Cr, and Leu-Zn-Cr led to an improved response in serum lipid profile over each supplement given alone.

Authors+Show Affiliations

Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, 516616471, Iran. hsadri@uni-bonn.de.Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, 72074, Tuebingen, Germany. Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, 516616471, Iran.Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, 72074, Tuebingen, Germany. Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, 516616471, Iran.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28409409

Citation

Sadri, Hassan, et al. "Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats With Type 2 Diabetes." Biological Trace Element Research, vol. 180, no. 2, 2017, pp. 246-254.
Sadri H, Larki NN, Kolahian S. Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. Biol Trace Elem Res. 2017;180(2):246-254.
Sadri, H., Larki, N. N., & Kolahian, S. (2017). Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. Biological Trace Element Research, 180(2), pp. 246-254. doi:10.1007/s12011-017-1014-2.
Sadri H, Larki NN, Kolahian S. Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats With Type 2 Diabetes. Biol Trace Elem Res. 2017;180(2):246-254. PubMed PMID: 28409409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. AU - Sadri,Hassan, AU - Larki,Negar Nowroozi, AU - Kolahian,Saeed, Y1 - 2017/04/13/ PY - 2017/01/31/received PY - 2017/04/04/accepted PY - 2017/4/15/pubmed PY - 2018/2/1/medline PY - 2017/4/15/entrez KW - Chromium KW - Leucine KW - Type 2 diabetes KW - Zinc SP - 246 EP - 254 JF - Biological trace element research JO - Biol Trace Elem Res VL - 180 IS - 2 N2 - For the increasing development of diabetes, dietary habits and using appropriate supplements can play important roles in the treatment or reduction of risk for this disease. The objective of this study was to investigate the effects of leucine (Leu), zinc (Zn), and chromium (Cr) supplementation, alone or in combination, in rats with type 2 diabetes (T2D). Seventy-seven adult male Wistar rats were randomly assigned in 11 groups, using nutritional supplements and insulin (INS) or glibenclamide (GLC). Supplementing Leu significantly reduced blood glucose, triglycerides (TG), nonesterified fatty acids (NEFA), low-density lipoprotein (LDL), and increased high-density lipoprotein (HDL) concentrations compared to vehicle-treated T2D animals, and those improvements were associated with reduced area under the 2-h blood glucose response curve (AUC). Supplementation of T2D animals with Zn improved serum lipid profile as well as blood glucose concentrations but was not comparable with the INS, GLC, and Leu groups. Supplementary Cr did not improve blood glucose and AUC in T2D rats, whereas it reduced serum TG and LDL and increased HDL concentrations. In conclusion, supplementation of diabetic rats with Leu was more effective in improving blood glucose and consequently decreasing glucose AUC than other nutritional supplements. Supplementary Zn and Cr only improved serum lipid profile. The combination of the nutritional supplements did not improve blood glucose level. Nevertheless, supplementation with Leu-Zn, Leu-Cr, Zn-Cr, and Leu-Zn-Cr led to an improved response in serum lipid profile over each supplement given alone. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/28409409/Hypoglycemic_and_Hypolipidemic_Effects_of_Leucine_Zinc_and_Chromium_Alone_and_in_Combination_in_Rats_with_Type_2_Diabetes_ L2 - https://dx.doi.org/10.1007/s12011-017-1014-2 DB - PRIME DP - Unbound Medicine ER -