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Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study.
Environ Int. 2017 07; 104:33-40.EI

Abstract

BACKGROUND

Maternal supply of thyroid hormones during pregnancy serves a critical role in fetal development. Although animal and in vitro studies provide evidence for thyroid hormone disruption as a result of bisphenol A (BPA) exposure, there is still a lack of evidence in human studies, particularly in the context of pregnancy.

OBJECTIVES

We aimed to explore the associations between urinary BPA concentrations and plasma thyroid hormone parameters during gestation in pregnant women, and also investigated potential windows of vulnerability during gestation.

METHODS

Our study population included 116 cases of preterm birth and 323 controls from a nested case-control study. We measured BPA in urine and thyroid hormone parameters in plasma samples collected at up to four study visits during pregnancy (median for each visit: 9.64, 17.9, 26.0, and 35.1weeks gestation). We used linear mixed models for repeated measures analyses, and multivariate linear regression models stratified by study visit to explore potential windows of susceptibility.

RESULTS

In our repeated measures analysis, BPA and thyrotropin (TSH) were inversely associated. An interquartile range (IQR) increase in BPA was associated with an 8.21% decrease in TSH (95% confidence interval [CI]: -14.2, -1.83), and a 4.79% increase in free T4 (95% CI: 0.82, 8.92). BPA and TSH were also inversely associated in our cross-sectional analyses at visits 3 and 4.

CONCLUSIONS

Our results suggest that TSH is inversely associated with urinary BPA in a consistent manner across pregnancy. Disruption of TSH levels during pregnancy can potentially impact child development and interfere with normal birth outcomes.

Authors+Show Affiliations

Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States.Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States.Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, United States.Division of Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States. Electronic address: meekerj@umich.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28410473

Citation

Aung, Max T., et al. "Thyroid Hormone Parameters During Pregnancy in Relation to Urinary Bisphenol a Concentrations: a Repeated Measures Study." Environment International, vol. 104, 2017, pp. 33-40.
Aung MT, Johns LE, Ferguson KK, et al. Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environ Int. 2017;104:33-40.
Aung, M. T., Johns, L. E., Ferguson, K. K., Mukherjee, B., McElrath, T. F., & Meeker, J. D. (2017). Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environment International, 104, 33-40. https://doi.org/10.1016/j.envint.2017.04.001
Aung MT, et al. Thyroid Hormone Parameters During Pregnancy in Relation to Urinary Bisphenol a Concentrations: a Repeated Measures Study. Environ Int. 2017;104:33-40. PubMed PMID: 28410473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. AU - Aung,Max T, AU - Johns,Lauren E, AU - Ferguson,Kelly K, AU - Mukherjee,Bhramar, AU - McElrath,Thomas F, AU - Meeker,John D, Y1 - 2017/04/13/ PY - 2016/11/01/received PY - 2017/03/31/revised PY - 2017/04/01/accepted PY - 2017/4/15/pubmed PY - 2018/2/6/medline PY - 2017/4/15/entrez SP - 33 EP - 40 JF - Environment international JO - Environ Int VL - 104 N2 - BACKGROUND: Maternal supply of thyroid hormones during pregnancy serves a critical role in fetal development. Although animal and in vitro studies provide evidence for thyroid hormone disruption as a result of bisphenol A (BPA) exposure, there is still a lack of evidence in human studies, particularly in the context of pregnancy. OBJECTIVES: We aimed to explore the associations between urinary BPA concentrations and plasma thyroid hormone parameters during gestation in pregnant women, and also investigated potential windows of vulnerability during gestation. METHODS: Our study population included 116 cases of preterm birth and 323 controls from a nested case-control study. We measured BPA in urine and thyroid hormone parameters in plasma samples collected at up to four study visits during pregnancy (median for each visit: 9.64, 17.9, 26.0, and 35.1weeks gestation). We used linear mixed models for repeated measures analyses, and multivariate linear regression models stratified by study visit to explore potential windows of susceptibility. RESULTS: In our repeated measures analysis, BPA and thyrotropin (TSH) were inversely associated. An interquartile range (IQR) increase in BPA was associated with an 8.21% decrease in TSH (95% confidence interval [CI]: -14.2, -1.83), and a 4.79% increase in free T4 (95% CI: 0.82, 8.92). BPA and TSH were also inversely associated in our cross-sectional analyses at visits 3 and 4. CONCLUSIONS: Our results suggest that TSH is inversely associated with urinary BPA in a consistent manner across pregnancy. Disruption of TSH levels during pregnancy can potentially impact child development and interfere with normal birth outcomes. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/28410473/Thyroid_hormone_parameters_during_pregnancy_in_relation_to_urinary_bisphenol_A_concentrations:_A_repeated_measures_study_ DB - PRIME DP - Unbound Medicine ER -