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Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population.
J Am Med Dir Assoc 2017; 18(8):671-677JA

Abstract

BACKGROUND

Chronic inflammation provides the substrate for various mechanisms involved in osteoporotic fracture. The Dietary Inflammatory Index (DII) could shed light on the effect of the inflammatory potential of the diet on osteoporotic hip fracture.

OBJECTIVE

This study tested the hypothesis that higher DII scores are associated with greater hip fracture risk in an elderly Chinese population.

METHODS

A 1:1 age- (±3 years), sex- and region-matched case-control study of 1050 pairs (female/male: 781/269) of elderly (age range = 52-83 years) Chinese was conducted in Guangdong, China (2009-2015). Cases were newly diagnosed (within 2 weeks) hip fracture patients and controls were recruited from either communities (n = 835 controls) or the hospital (n = 215). DII scores were calculated from self-reports using a validated 79-item food frequency questionnaire. Odds ratios (ORs) and their 95% confidence intervals (CIs) of the risk of hip fracture for DII scores were estimated from conditional logistic regression.

RESULTS

The multivariable-adjusted ORs (95% CIs) for hip fracture across quartiles of DII scores were 1 (reference), 1.42 (1.01, 1.99), 1.63 (1.16, 2.28), and 2.44 (1.73, 3.45) (P trend <.001). Comparing extreme quartiles, the adjusted ORs (95% CIs) for hip fractures were 2.08 (1.38, 3.12) for female and 4.30 (1.89, 9.80) for male participants, respectively (P interaction = .26). When stratified by the source of controls, a dose-response positive relationship was observed between DII scores and hip fracture risk among community-based controls but not those from the hospital (P interaction = .16).

CONCLUSIONS

A proinflammatory diet appears to be positively associated with hip fracture risk.

Authors+Show Affiliations

Department of Medical Statistics and Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.Department of Medical Statistics and Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.Cancer Prevention and Control Program, University of South Carolina, Columbia, SC; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC; Connecting Health Innovations LLC, Columbia, SC.Cancer Prevention and Control Program, University of South Carolina, Columbia, SC; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC; Connecting Health Innovations LLC, Columbia, SC.Guangzhou Orthopaedics Trauma Hospital, Guangzhou, China.Department of Medical Statistics and Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.Department of Medical Statistics and Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: chenyum@mail.sysu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28411093

Citation

Zhang, Zhe-Qing, et al. "Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population." Journal of the American Medical Directors Association, vol. 18, no. 8, 2017, pp. 671-677.
Zhang ZQ, Cao WT, Shivappa N, et al. Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population. J Am Med Dir Assoc. 2017;18(8):671-677.
Zhang, Z. Q., Cao, W. T., Shivappa, N., Hebert, J. R., Li, B. L., He, J., ... Chen, Y. M. (2017). Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population. Journal of the American Medical Directors Association, 18(8), pp. 671-677. doi:10.1016/j.jamda.2017.02.011.
Zhang ZQ, et al. Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population. J Am Med Dir Assoc. 2017 Aug 1;18(8):671-677. PubMed PMID: 28411093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population. AU - Zhang,Zhe-Qing, AU - Cao,Wen-Ting, AU - Shivappa,Nitin, AU - Hebert,James R, AU - Li,Bao-Lin, AU - He,Juan, AU - Tang,Xin-Yi, AU - Liang,Ya-Yong, AU - Chen,Yu-Ming, Y1 - 2017/04/11/ PY - 2016/12/10/received PY - 2017/02/06/revised PY - 2017/02/13/accepted PY - 2017/4/16/pubmed PY - 2018/5/23/medline PY - 2017/4/16/entrez KW - Case-control study KW - Dietary Inflammatory Index KW - hip fracture SP - 671 EP - 677 JF - Journal of the American Medical Directors Association JO - J Am Med Dir Assoc VL - 18 IS - 8 N2 - BACKGROUND: Chronic inflammation provides the substrate for various mechanisms involved in osteoporotic fracture. The Dietary Inflammatory Index (DII) could shed light on the effect of the inflammatory potential of the diet on osteoporotic hip fracture. OBJECTIVE: This study tested the hypothesis that higher DII scores are associated with greater hip fracture risk in an elderly Chinese population. METHODS: A 1:1 age- (±3 years), sex- and region-matched case-control study of 1050 pairs (female/male: 781/269) of elderly (age range = 52-83 years) Chinese was conducted in Guangdong, China (2009-2015). Cases were newly diagnosed (within 2 weeks) hip fracture patients and controls were recruited from either communities (n = 835 controls) or the hospital (n = 215). DII scores were calculated from self-reports using a validated 79-item food frequency questionnaire. Odds ratios (ORs) and their 95% confidence intervals (CIs) of the risk of hip fracture for DII scores were estimated from conditional logistic regression. RESULTS: The multivariable-adjusted ORs (95% CIs) for hip fracture across quartiles of DII scores were 1 (reference), 1.42 (1.01, 1.99), 1.63 (1.16, 2.28), and 2.44 (1.73, 3.45) (P trend <.001). Comparing extreme quartiles, the adjusted ORs (95% CIs) for hip fractures were 2.08 (1.38, 3.12) for female and 4.30 (1.89, 9.80) for male participants, respectively (P interaction = .26). When stratified by the source of controls, a dose-response positive relationship was observed between DII scores and hip fracture risk among community-based controls but not those from the hospital (P interaction = .16). CONCLUSIONS: A proinflammatory diet appears to be positively associated with hip fracture risk. SN - 1538-9375 UR - https://www.unboundmedicine.com/medline/citation/28411093/Association_Between_Diet_Inflammatory_Index_and_Osteoporotic_Hip_Fracture_in_Elderly_Chinese_Population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-8610(17)30106-8 DB - PRIME DP - Unbound Medicine ER -