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Synergistic effect between D-AP5 and muscimol in the nucleus accumbens shell on memory consolidation deficit in adult male Wistar rats: An isobologram analysis.
Neurobiol Learn Mem. 2017 May; 141:134-142.NL

Abstract

The nucleus accumbens (NAc) glutamatergic and GABAergic systems are involved in memory processes. This study was investigated the involvement of NAc shell GABAergic system on D-AP5 induced memory consolidation deficit. The elevated plus-maze (EPM) test-retest paradigm was employed to assess memory in adult male Wistar rats. The results indicated that post-training intra-NAc shell injection of bicuculline (GABAA receptor antagonist) did not alter emotional memory consolidation. However, post-training intra-NAc shell microinjection of muscimol (GABAA receptor agonist, 0.1μg/rat) and D-AP5 (a competitive NMDA receptor antagonist, 4μg/rat) decreased emotional memory consolidation, suggesting the drugs induced amnesia. Moreover, a sub-threshold dose of muscimol (0.05μg/rat) potentiated the D-AP5 (2μg/rat) response on memory consolidation impairment. On the other hand, the middle dose of bicuculline (0.25μg/rat) reversed memory impairment induced by D-AP5 at the higher dose. Interestingly, there is a synergistic effect between D-AP5 and muscimol on impairment of emotional memory consolidation. None of the above doses changed the locomotor activity. Our results suggest that the glutamatergic and GABAergic neurons of the NAc shell interact with each other for modulation of emotional memory consolidation.

Authors+Show Affiliations

Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. Electronic address: nasehi@iricss.org.Department of Pharmacology and Toxicology, Islamic Azad University, Pharmaceutical Science Branch (IAUPS), Tehran, Iran.Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.Department of Biology, Faculty of Sciences, University of Zanjan, Zanjan, Iran.Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran. Electronic address: zarinmr@ams.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28412304

Citation

Nasehi, Mohammad, et al. "Synergistic Effect Between D-AP5 and Muscimol in the Nucleus Accumbens Shell On Memory Consolidation Deficit in Adult Male Wistar Rats: an Isobologram Analysis." Neurobiology of Learning and Memory, vol. 141, 2017, pp. 134-142.
Nasehi M, Ostadi E, Khakpai F, et al. Synergistic effect between D-AP5 and muscimol in the nucleus accumbens shell on memory consolidation deficit in adult male Wistar rats: An isobologram analysis. Neurobiol Learn Mem. 2017;141:134-142.
Nasehi, M., Ostadi, E., Khakpai, F., Ebrahimi-Ghiri, M., & Zarrindast, M. R. (2017). Synergistic effect between D-AP5 and muscimol in the nucleus accumbens shell on memory consolidation deficit in adult male Wistar rats: An isobologram analysis. Neurobiology of Learning and Memory, 141, 134-142. https://doi.org/10.1016/j.nlm.2017.03.022
Nasehi M, et al. Synergistic Effect Between D-AP5 and Muscimol in the Nucleus Accumbens Shell On Memory Consolidation Deficit in Adult Male Wistar Rats: an Isobologram Analysis. Neurobiol Learn Mem. 2017;141:134-142. PubMed PMID: 28412304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic effect between D-AP5 and muscimol in the nucleus accumbens shell on memory consolidation deficit in adult male Wistar rats: An isobologram analysis. AU - Nasehi,Mohammad, AU - Ostadi,Elaheh, AU - Khakpai,Fatemeh, AU - Ebrahimi-Ghiri,Mohaddeseh, AU - Zarrindast,Mohammad-Reza, Y1 - 2017/04/12/ PY - 2016/09/29/received PY - 2017/01/15/revised PY - 2017/03/25/accepted PY - 2017/4/17/pubmed PY - 2018/3/27/medline PY - 2017/4/17/entrez KW - D-AP5 KW - EPM apparatus KW - Emotional memory consolidation KW - GABA(A) receptor KW - NMDA KW - The NAc-shell SP - 134 EP - 142 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 141 N2 - The nucleus accumbens (NAc) glutamatergic and GABAergic systems are involved in memory processes. This study was investigated the involvement of NAc shell GABAergic system on D-AP5 induced memory consolidation deficit. The elevated plus-maze (EPM) test-retest paradigm was employed to assess memory in adult male Wistar rats. The results indicated that post-training intra-NAc shell injection of bicuculline (GABAA receptor antagonist) did not alter emotional memory consolidation. However, post-training intra-NAc shell microinjection of muscimol (GABAA receptor agonist, 0.1μg/rat) and D-AP5 (a competitive NMDA receptor antagonist, 4μg/rat) decreased emotional memory consolidation, suggesting the drugs induced amnesia. Moreover, a sub-threshold dose of muscimol (0.05μg/rat) potentiated the D-AP5 (2μg/rat) response on memory consolidation impairment. On the other hand, the middle dose of bicuculline (0.25μg/rat) reversed memory impairment induced by D-AP5 at the higher dose. Interestingly, there is a synergistic effect between D-AP5 and muscimol on impairment of emotional memory consolidation. None of the above doses changed the locomotor activity. Our results suggest that the glutamatergic and GABAergic neurons of the NAc shell interact with each other for modulation of emotional memory consolidation. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/28412304/Synergistic_effect_between_D_AP5_and_muscimol_in_the_nucleus_accumbens_shell_on_memory_consolidation_deficit_in_adult_male_Wistar_rats:_An_isobologram_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(16)30231-3 DB - PRIME DP - Unbound Medicine ER -