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Improved release of triamcinolone acetonide from medicated soft contact lenses loaded with drug nanosuspensions.
Int J Pharm. 2017 Jun 15; 525(1):226-236.IJ

Abstract

Drug nanosuspensions (NSs) show a significant potential to improve loading and release properties of the poorly water soluble drug triamcinolone acetonide (TA) from poly(hydroxyethyl methacrylate) (pHEMA) soft contact lenses. In this work, TA NSs were developed by a controlled precipitation method using a fractional factorial Plackett-Burmann design. Poloxamer 407 (PL) and polyvinyl alcohol (PVA) as stabilizing agents were selected. NSs were characterized in terms of their drug content, particle size and morphology. Results indicate that all studied factors, except homogenization speed and sonication, have significant influence on the drug incorporation yield into NSs. Drug nanoparticles showed an interesting size that may be suitable for their incorporation into topical ocular drug delivery systems, as hydrogels. pHEMA hydrogels and daily-wear Hilafilcon B commercial contact lenses (SCLs) were employed to study TA loading capacity and drug release properties using NSs as loading system. Hydrogels have been synthesised by copolymerization of 2-hydroxyethyl methacrylate (HEMA) with methacrylic acid (MA) in accordance with a previous work (García-Millán et al., 2015). Both synthesised hydrogels and SCLs were characterized in terms of their mechanical and physical properties and TA loading and release properties. Selected TA NS was further characterized by studying its physical-chemical stability during the loading process. Results show that the use of TA NSs as loading medium significantly increases drug loading capacity and release of soft contact lenses in comparison with drug saturated solution. Synthesised pHEMA hydrogels and SCLs lenses have good properties as ophthalmic drug delivery systems, but SCLs load higher quantities of drug and release TA in shorter time periods than synthesised pHEMA hydrogel.

Authors+Show Affiliations

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782, Santiago de Compostela, Spain.Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782, Santiago de Compostela, Spain.Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782, Santiago de Compostela, Spain; Instituto de Farmacia Industrial, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782, Santiago de Compostela, Spain. Electronic address: francisco.otero@usc.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28412447

Citation

García-Millán, Eva, et al. "Improved Release of Triamcinolone Acetonide From Medicated Soft Contact Lenses Loaded With Drug Nanosuspensions." International Journal of Pharmaceutics, vol. 525, no. 1, 2017, pp. 226-236.
García-Millán E, Quintáns-Carballo M, Otero-Espinar FJ. Improved release of triamcinolone acetonide from medicated soft contact lenses loaded with drug nanosuspensions. Int J Pharm. 2017;525(1):226-236.
García-Millán, E., Quintáns-Carballo, M., & Otero-Espinar, F. J. (2017). Improved release of triamcinolone acetonide from medicated soft contact lenses loaded with drug nanosuspensions. International Journal of Pharmaceutics, 525(1), 226-236. https://doi.org/10.1016/j.ijpharm.2017.03.082
García-Millán E, Quintáns-Carballo M, Otero-Espinar FJ. Improved Release of Triamcinolone Acetonide From Medicated Soft Contact Lenses Loaded With Drug Nanosuspensions. Int J Pharm. 2017 Jun 15;525(1):226-236. PubMed PMID: 28412447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved release of triamcinolone acetonide from medicated soft contact lenses loaded with drug nanosuspensions. AU - García-Millán,Eva, AU - Quintáns-Carballo,Mónica, AU - Otero-Espinar,Francisco Javier, Y1 - 2017/04/12/ PY - 2017/01/03/received PY - 2017/03/27/revised PY - 2017/03/29/accepted PY - 2017/4/17/pubmed PY - 2018/1/9/medline PY - 2017/4/17/entrez KW - 2,2′-Azo-bis(isobutyronitrile) AIBN (CID 6547) KW - 2-Hydroxyethyl methacrylate HEMA (CID 13360) KW - Ethyleneglycol dimethacrylate EGDMA (CID:7355) Poloxamer 407 KW - Medicated soft contact lenses KW - Methacrylic acid MA (CID: 4093) KW - Nanosuspensions KW - Ocular KW - Ocular drug release KW - Polyvinyl alcohol PVA (CID 11199) KW - Triamcinolone Acetonide TA (CID: 6436) KW - Triamcinolone acetonide KW - pHEMA hydrogels SP - 226 EP - 236 JF - International journal of pharmaceutics JO - Int J Pharm VL - 525 IS - 1 N2 - Drug nanosuspensions (NSs) show a significant potential to improve loading and release properties of the poorly water soluble drug triamcinolone acetonide (TA) from poly(hydroxyethyl methacrylate) (pHEMA) soft contact lenses. In this work, TA NSs were developed by a controlled precipitation method using a fractional factorial Plackett-Burmann design. Poloxamer 407 (PL) and polyvinyl alcohol (PVA) as stabilizing agents were selected. NSs were characterized in terms of their drug content, particle size and morphology. Results indicate that all studied factors, except homogenization speed and sonication, have significant influence on the drug incorporation yield into NSs. Drug nanoparticles showed an interesting size that may be suitable for their incorporation into topical ocular drug delivery systems, as hydrogels. pHEMA hydrogels and daily-wear Hilafilcon B commercial contact lenses (SCLs) were employed to study TA loading capacity and drug release properties using NSs as loading system. Hydrogels have been synthesised by copolymerization of 2-hydroxyethyl methacrylate (HEMA) with methacrylic acid (MA) in accordance with a previous work (García-Millán et al., 2015). Both synthesised hydrogels and SCLs were characterized in terms of their mechanical and physical properties and TA loading and release properties. Selected TA NS was further characterized by studying its physical-chemical stability during the loading process. Results show that the use of TA NSs as loading medium significantly increases drug loading capacity and release of soft contact lenses in comparison with drug saturated solution. Synthesised pHEMA hydrogels and SCLs lenses have good properties as ophthalmic drug delivery systems, but SCLs load higher quantities of drug and release TA in shorter time periods than synthesised pHEMA hydrogel. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/28412447/Improved_release_of_triamcinolone_acetonide_from_medicated_soft_contact_lenses_loaded_with_drug_nanosuspensions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(17)30269-7 DB - PRIME DP - Unbound Medicine ER -