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The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental area mediate morphine-induced memory consolidation impairment.
Neuroscience. 2017 06 14; 353:7-16.N

Abstract

In the present study, we investigated the possible participation of the endocannabinoid system in the basolateral amygdala and N-methyl-d-aspartate (NMDA) or GABA-A receptor neurotransmission in the ventral tegmental area in the memory consolidation impairment induced by morphine administration. To measure memory formation, step-through type passive avoidance apparatus was used with adult male Wistar rats. The results showed that intraperitoneal (i.p.) administration of morphine (3 and 6mg/kg) after the successful training phase had an amnestic effect and induced memory consolidation impairment. After training, injection of a selective cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA; 0.4-0.6ng/rat) plus systemic injection of an ineffective dose of morphine (0.5mg/kg, i.p.) into the basolateral amygdala impaired memory consolidation suggesting the facilitatory effect of ACPA on morphine response. Also, the results showed that the injection of bicuculline, a GABA-A receptor antagonist (0.3-0.5µg/rat) or NMDA (0.005-0.02µg/rat) into the ventral tegmental area reversed ACPA-induced potentiation of morphine response and improved memory consolidation. It should be considered that the injection of ACPA into the basolateral amygdala and the injection of bicuculline or NMDA into the ventral tegmental area alone could not affect memory consolidation. Taken together, it seems that there is a functional interaction between the basolateral amygdala endocannabinoid system and the ventral tegmental area GABAergic- or glutamatergic neurotransmission in the modulation of morphine-induced memory consolidation impairment.

Authors+Show Affiliations

Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Khadijeh.Sharifi@gmail.com.Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Neuroscience, School of Advanced Technologies in Medicine and Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Institute for Studies in Theoretical Physics and Mathematics School of Cognitive Sciences (IPM), Tehran, Iran; Institute of Cognitive Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran, Iran. Electronic address: zarinmr@ams.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28412500

Citation

Sharifi, Khadijeh Alsadat, et al. "The Major Neurotransmitter Systems in the Basolateral Amygdala and the Ventral Tegmental Area Mediate Morphine-induced Memory Consolidation Impairment." Neuroscience, vol. 353, 2017, pp. 7-16.
Sharifi KA, Rezayof A, Torkaman-Boutorabi A, et al. The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental area mediate morphine-induced memory consolidation impairment. Neuroscience. 2017;353:7-16.
Sharifi, K. A., Rezayof, A., Torkaman-Boutorabi, A., & Zarrindast, M. R. (2017). The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental area mediate morphine-induced memory consolidation impairment. Neuroscience, 353, 7-16. https://doi.org/10.1016/j.neuroscience.2017.03.036
Sharifi KA, et al. The Major Neurotransmitter Systems in the Basolateral Amygdala and the Ventral Tegmental Area Mediate Morphine-induced Memory Consolidation Impairment. Neuroscience. 2017 06 14;353:7-16. PubMed PMID: 28412500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental area mediate morphine-induced memory consolidation impairment. AU - Sharifi,Khadijeh Alsadat, AU - Rezayof,Ameneh, AU - Torkaman-Boutorabi,Anahita, AU - Zarrindast,Mohammad-Reza, Y1 - 2017/04/12/ PY - 2016/10/06/received PY - 2017/03/11/revised PY - 2017/03/23/accepted PY - 2017/4/17/pubmed PY - 2018/3/15/medline PY - 2017/4/17/entrez KW - basolateral amygdala KW - morphine amnesia KW - neurotransmitter systems KW - rat(s) KW - ventral tegmental area SP - 7 EP - 16 JF - Neuroscience JO - Neuroscience VL - 353 N2 - In the present study, we investigated the possible participation of the endocannabinoid system in the basolateral amygdala and N-methyl-d-aspartate (NMDA) or GABA-A receptor neurotransmission in the ventral tegmental area in the memory consolidation impairment induced by morphine administration. To measure memory formation, step-through type passive avoidance apparatus was used with adult male Wistar rats. The results showed that intraperitoneal (i.p.) administration of morphine (3 and 6mg/kg) after the successful training phase had an amnestic effect and induced memory consolidation impairment. After training, injection of a selective cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA; 0.4-0.6ng/rat) plus systemic injection of an ineffective dose of morphine (0.5mg/kg, i.p.) into the basolateral amygdala impaired memory consolidation suggesting the facilitatory effect of ACPA on morphine response. Also, the results showed that the injection of bicuculline, a GABA-A receptor antagonist (0.3-0.5µg/rat) or NMDA (0.005-0.02µg/rat) into the ventral tegmental area reversed ACPA-induced potentiation of morphine response and improved memory consolidation. It should be considered that the injection of ACPA into the basolateral amygdala and the injection of bicuculline or NMDA into the ventral tegmental area alone could not affect memory consolidation. Taken together, it seems that there is a functional interaction between the basolateral amygdala endocannabinoid system and the ventral tegmental area GABAergic- or glutamatergic neurotransmission in the modulation of morphine-induced memory consolidation impairment. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/28412500/The_major_neurotransmitter_systems_in_the_basolateral_amygdala_and_the_ventral_tegmental_area_mediate_morphine_induced_memory_consolidation_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(17)30202-6 DB - PRIME DP - Unbound Medicine ER -