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Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients with Rheumatoid Arthritis and Inadequate Response to MTX: A Systematic Literature Review.
J Rheumatol 2017; 44(6):773-779JR

Abstract

OBJECTIVE

For patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate (MTX), the relative effectiveness of the combination of conventional disease-modifying antirheumatic drugs (DMARD) compared with the combination of tumor necrosis factor (TNF) inhibitors and MTX, as second-line therapy, is uncertain. The aim of this study was to compare the efficacy and tolerance of triple oral DMARD therapy versus anti-TNF agents associated with MTX in patients with RA after MTX failure.

METHODS

We performed a systematic search of the literature up to November 2015 in MEDLINE, Embase, the Cochrane library, and abstracts from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) meetings from 2006 to 2015. Articles were included if they were of randomized controlled trials of patients receiving triple oral combination therapy (TT; MTX + sulfasalazine + hydroxychloroquine) compared with anti-TNF agents plus MTX. Treatment effects were examined by disease activity [Disease Activity Score in 28 joints (DAS28)], ACR and EULAR response criteria, structural damage by the modified total Sharp score, and functional disability by the Health Assessment Questionnaire (HAQ).

RESULTS

Our search identified 263 articles; only 5 fulfilled the selection criteria. Analysis of ACR and EULAR response criteria, DAS28, and modified Sharp scores favored anti-TNF agents combined with MTX. Functional disability (HAQ) and rates of adverse events did not differ between treatments.

CONCLUSION

In patients with RA in whom MTX has failed, the addition of a TNF antagonist to MTX may be a valid option, with better clinical outcomes and better radiographic results in the presence of poor prognostic factors. In the absence of poor prognostic factors and/or with contraindications to biologic agents, TT retains its place in the therapeutic strategy for RA in a currently restricted economic context.

Authors+Show Affiliations

From the Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), Fort-de-France, Martinique, French West Indies; Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535, Montpellier, France. code.juliamary@gmail.com. B. Combe has received honoraria from BMS, Lilly, Merck, Pfizer, Roche-Chugai, and UCB. J. Morel has received honoraria from Abbvie, BMS, Merck, and Pfizer. C. Lukas has received honoraria from BMS, Merck, Pfizer, Roche-Chugai, UCB, Nordic Pharma, and Abbvie. code.juliamary@gmail.com. J. Mary, MD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), and Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; M. De Bandt, MD, PhD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital); C. Lukas, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; J. Morel, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; B. Combe, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535. code.juliamary@gmail.com.From the Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), Fort-de-France, Martinique, French West Indies; Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535, Montpellier, France. B. Combe has received honoraria from BMS, Lilly, Merck, Pfizer, Roche-Chugai, and UCB. J. Morel has received honoraria from Abbvie, BMS, Merck, and Pfizer. C. Lukas has received honoraria from BMS, Merck, Pfizer, Roche-Chugai, UCB, Nordic Pharma, and Abbvie. J. Mary, MD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), and Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; M. De Bandt, MD, PhD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital); C. Lukas, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; J. Morel, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; B. Combe, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535.From the Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), Fort-de-France, Martinique, French West Indies; Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535, Montpellier, France. B. Combe has received honoraria from BMS, Lilly, Merck, Pfizer, Roche-Chugai, and UCB. J. Morel has received honoraria from Abbvie, BMS, Merck, and Pfizer. C. Lukas has received honoraria from BMS, Merck, Pfizer, Roche-Chugai, UCB, Nordic Pharma, and Abbvie. J. Mary, MD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), and Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; M. De Bandt, MD, PhD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital); C. Lukas, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; J. Morel, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; B. Combe, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535.From the Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), Fort-de-France, Martinique, French West Indies; Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535, Montpellier, France. B. Combe has received honoraria from BMS, Lilly, Merck, Pfizer, Roche-Chugai, and UCB. J. Morel has received honoraria from Abbvie, BMS, Merck, and Pfizer. C. Lukas has received honoraria from BMS, Merck, Pfizer, Roche-Chugai, UCB, Nordic Pharma, and Abbvie. J. Mary, MD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), and Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; M. De Bandt, MD, PhD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital); C. Lukas, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; J. Morel, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; B. Combe, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535.From the Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), Fort-de-France, Martinique, French West Indies; Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535, Montpellier, France. B. Combe has received honoraria from BMS, Lilly, Merck, Pfizer, Roche-Chugai, and UCB. J. Morel has received honoraria from Abbvie, BMS, Merck, and Pfizer. C. Lukas has received honoraria from BMS, Merck, Pfizer, Roche-Chugai, UCB, Nordic Pharma, and Abbvie. J. Mary, MD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital), and Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; M. De Bandt, MD, PhD, Rheumatology Department, CHU Martinique (Pierre Zobda-Quitman Hospital); C. Lukas, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; J. Morel, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535; B. Combe, MD, PhD, Rheumatology Department, CHU Montpellier, Lapeyronie Hospital, Montpellier University, UMR5535.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28412710

Citation

Mary, Julia, et al. "Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients With Rheumatoid Arthritis and Inadequate Response to MTX: a Systematic Literature Review." The Journal of Rheumatology, vol. 44, no. 6, 2017, pp. 773-779.
Mary J, De Bandt M, Lukas C, et al. Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients with Rheumatoid Arthritis and Inadequate Response to MTX: A Systematic Literature Review. J Rheumatol. 2017;44(6):773-779.
Mary, J., De Bandt, M., Lukas, C., Morel, J., & Combe, B. (2017). Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients with Rheumatoid Arthritis and Inadequate Response to MTX: A Systematic Literature Review. The Journal of Rheumatology, 44(6), pp. 773-779. doi:10.3899/jrheum.160643.
Mary J, et al. Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients With Rheumatoid Arthritis and Inadequate Response to MTX: a Systematic Literature Review. J Rheumatol. 2017;44(6):773-779. PubMed PMID: 28412710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients with Rheumatoid Arthritis and Inadequate Response to MTX: A Systematic Literature Review. AU - Mary,Julia, AU - De Bandt,Michel, AU - Lukas,Cédric, AU - Morel,Jacques, AU - Combe,Bernard, Y1 - 2017/04/15/ PY - 2017/02/17/accepted PY - 2017/4/17/pubmed PY - 2018/3/27/medline PY - 2017/4/17/entrez KW - CONVENTIONAL TREATMENT KW - DMARD KW - RHEUMATOID ARTHRITIS KW - TNF INHIBITORS KW - TRIPLE THERAPY SP - 773 EP - 779 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 44 IS - 6 N2 - OBJECTIVE: For patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate (MTX), the relative effectiveness of the combination of conventional disease-modifying antirheumatic drugs (DMARD) compared with the combination of tumor necrosis factor (TNF) inhibitors and MTX, as second-line therapy, is uncertain. The aim of this study was to compare the efficacy and tolerance of triple oral DMARD therapy versus anti-TNF agents associated with MTX in patients with RA after MTX failure. METHODS: We performed a systematic search of the literature up to November 2015 in MEDLINE, Embase, the Cochrane library, and abstracts from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) meetings from 2006 to 2015. Articles were included if they were of randomized controlled trials of patients receiving triple oral combination therapy (TT; MTX + sulfasalazine + hydroxychloroquine) compared with anti-TNF agents plus MTX. Treatment effects were examined by disease activity [Disease Activity Score in 28 joints (DAS28)], ACR and EULAR response criteria, structural damage by the modified total Sharp score, and functional disability by the Health Assessment Questionnaire (HAQ). RESULTS: Our search identified 263 articles; only 5 fulfilled the selection criteria. Analysis of ACR and EULAR response criteria, DAS28, and modified Sharp scores favored anti-TNF agents combined with MTX. Functional disability (HAQ) and rates of adverse events did not differ between treatments. CONCLUSION: In patients with RA in whom MTX has failed, the addition of a TNF antagonist to MTX may be a valid option, with better clinical outcomes and better radiographic results in the presence of poor prognostic factors. In the absence of poor prognostic factors and/or with contraindications to biologic agents, TT retains its place in the therapeutic strategy for RA in a currently restricted economic context. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/28412710/Triple_Oral_Therapy_Versus_Antitumor_Necrosis_Factor_Plus_Methotrexate__MTX__in_Patients_with_Rheumatoid_Arthritis_and_Inadequate_Response_to_MTX:_A_Systematic_Literature_Review_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=28412710 DB - PRIME DP - Unbound Medicine ER -