Tags

Type your tag names separated by a space and hit enter

25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient.

Abstract

Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department. 51 controls were from the physical checkup center of the hospital. 25-Hydroxyvitamin D levels, thyroid function, antithyroid antibodies, IL-4, IL-17, and TNF-α were determined. Compared with the controls, treated and mild HT patients had significantly lower 25(OH)D levels (45.77±3.48 vs. 83.49±6.24 nmol/L, p<0.001) and (55.25±3.88 vs. 83.49±6.24 nmol/L, p<0.001), respectively. However, GD patients had similar 25(OH)D levels (81.77±5.60 vs. 83.49±6.24 nmol/L, p=0.808). Compared to 24.1% controls with prevalent vitamin D deficiency, mild HT and treated HT patients were significantly different (55.4%, p<0.001) and (70.3%, p<0.001), respectively; no difference was seen in the GD patients (22.9%, p=0.797). Serum 25(OH)D levels were not associated with thyroid function, antithyroid antibodies, and serum cytokines IL-4, IL-17, and TNF-α in patients with AITD. We observed relatively low vitamin D level in mild and treated HT patients, while GD patients had similar 25(OH)D levels to those of healthy individuals. Further studies are imperative to explore the complex etiology of vitamin D deficiency in AITD.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

    ,

    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

    ,

    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

    ,

    Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

    ,

    Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

    ,

    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

    Source

    Endocrine journal 64:6 2017 Jun 29 pg 581-587

    MeSH

    Adult
    Autoimmunity
    Calcifediol
    Case-Control Studies
    China
    Female
    Graves Disease
    Hashimoto Disease
    Hormone Replacement Therapy
    Humans
    Hypothyroidism
    Male
    Middle Aged
    Nutritional Status
    Prevalence
    Risk Factors
    Severity of Illness Index
    Thyroid Gland
    Vitamin D Deficiency

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    28413173

    Citation

    Ke, Wencai, et al. "25-Hydroxyvitamin D Serum Level in Hashimoto's Thyroiditis, but Not Graves' Disease Is Relatively Deficient." Endocrine Journal, vol. 64, no. 6, 2017, pp. 581-587.
    Ke W, Sun T, Zhang Y, et al. 25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient. Endocr J. 2017;64(6):581-587.
    Ke, W., Sun, T., Zhang, Y., He, L., Wu, Q., Liu, J., & Zha, B. (2017). 25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient. Endocrine Journal, 64(6), pp. 581-587. doi:10.1507/endocrj.EJ16-0547.
    Ke W, et al. 25-Hydroxyvitamin D Serum Level in Hashimoto's Thyroiditis, but Not Graves' Disease Is Relatively Deficient. Endocr J. 2017 Jun 29;64(6):581-587. PubMed PMID: 28413173.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - 25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient. AU - Ke,Wencai, AU - Sun,Tiange, AU - Zhang,Yanan, AU - He,Leqi, AU - Wu,Qiang, AU - Liu,Jun, AU - Zha,Bingbing, Y1 - 2017/04/11/ PY - 2017/4/18/pubmed PY - 2018/5/31/medline PY - 2017/4/18/entrez KW - Autoimmune thyroid diseases KW - Graves’ disease KW - Hashimoto’s thyroiditis KW - Serum 25-Hydroxyvitamin D KW - Vitamin D deficiency SP - 581 EP - 587 JF - Endocrine journal JO - Endocr. J. VL - 64 IS - 6 N2 - Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department. 51 controls were from the physical checkup center of the hospital. 25-Hydroxyvitamin D levels, thyroid function, antithyroid antibodies, IL-4, IL-17, and TNF-α were determined. Compared with the controls, treated and mild HT patients had significantly lower 25(OH)D levels (45.77±3.48 vs. 83.49±6.24 nmol/L, p<0.001) and (55.25±3.88 vs. 83.49±6.24 nmol/L, p<0.001), respectively. However, GD patients had similar 25(OH)D levels (81.77±5.60 vs. 83.49±6.24 nmol/L, p=0.808). Compared to 24.1% controls with prevalent vitamin D deficiency, mild HT and treated HT patients were significantly different (55.4%, p<0.001) and (70.3%, p<0.001), respectively; no difference was seen in the GD patients (22.9%, p=0.797). Serum 25(OH)D levels were not associated with thyroid function, antithyroid antibodies, and serum cytokines IL-4, IL-17, and TNF-α in patients with AITD. We observed relatively low vitamin D level in mild and treated HT patients, while GD patients had similar 25(OH)D levels to those of healthy individuals. Further studies are imperative to explore the complex etiology of vitamin D deficiency in AITD. SN - 1348-4540 UR - https://www.unboundmedicine.com/medline/citation/28413173/25_Hydroxyvitamin_D_serum_level_in_Hashimoto's_thyroiditis_but_not_Graves'_disease_is_relatively_deficient_ L2 - https://dx.doi.org/10.1507/endocrj.EJ16-0547 DB - PRIME DP - Unbound Medicine ER -