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25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient.
Endocr J 2017; 64(6):581-587EJ

Abstract

Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department. 51 controls were from the physical checkup center of the hospital. 25-Hydroxyvitamin D levels, thyroid function, antithyroid antibodies, IL-4, IL-17, and TNF-α were determined. Compared with the controls, treated and mild HT patients had significantly lower 25(OH)D levels (45.77±3.48 vs. 83.49±6.24 nmol/L, p<0.001) and (55.25±3.88 vs. 83.49±6.24 nmol/L, p<0.001), respectively. However, GD patients had similar 25(OH)D levels (81.77±5.60 vs. 83.49±6.24 nmol/L, p=0.808). Compared to 24.1% controls with prevalent vitamin D deficiency, mild HT and treated HT patients were significantly different (55.4%, p<0.001) and (70.3%, p<0.001), respectively; no difference was seen in the GD patients (22.9%, p=0.797). Serum 25(OH)D levels were not associated with thyroid function, antithyroid antibodies, and serum cytokines IL-4, IL-17, and TNF-α in patients with AITD. We observed relatively low vitamin D level in mild and treated HT patients, while GD patients had similar 25(OH)D levels to those of healthy individuals. Further studies are imperative to explore the complex etiology of vitamin D deficiency in AITD.

Authors+Show Affiliations

Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28413173

Citation

Ke, Wencai, et al. "25-Hydroxyvitamin D Serum Level in Hashimoto's Thyroiditis, but Not Graves' Disease Is Relatively Deficient." Endocrine Journal, vol. 64, no. 6, 2017, pp. 581-587.
Ke W, Sun T, Zhang Y, et al. 25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient. Endocr J. 2017;64(6):581-587.
Ke, W., Sun, T., Zhang, Y., He, L., Wu, Q., Liu, J., & Zha, B. (2017). 25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient. Endocrine Journal, 64(6), pp. 581-587. doi:10.1507/endocrj.EJ16-0547.
Ke W, et al. 25-Hydroxyvitamin D Serum Level in Hashimoto's Thyroiditis, but Not Graves' Disease Is Relatively Deficient. Endocr J. 2017 Jun 29;64(6):581-587. PubMed PMID: 28413173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient. AU - Ke,Wencai, AU - Sun,Tiange, AU - Zhang,Yanan, AU - He,Leqi, AU - Wu,Qiang, AU - Liu,Jun, AU - Zha,Bingbing, Y1 - 2017/04/11/ PY - 2017/4/18/pubmed PY - 2018/5/31/medline PY - 2017/4/18/entrez KW - Autoimmune thyroid diseases KW - Graves’ disease KW - Hashimoto’s thyroiditis KW - Serum 25-Hydroxyvitamin D KW - Vitamin D deficiency SP - 581 EP - 587 JF - Endocrine journal JO - Endocr. J. VL - 64 IS - 6 N2 - Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department. 51 controls were from the physical checkup center of the hospital. 25-Hydroxyvitamin D levels, thyroid function, antithyroid antibodies, IL-4, IL-17, and TNF-α were determined. Compared with the controls, treated and mild HT patients had significantly lower 25(OH)D levels (45.77±3.48 vs. 83.49±6.24 nmol/L, p<0.001) and (55.25±3.88 vs. 83.49±6.24 nmol/L, p<0.001), respectively. However, GD patients had similar 25(OH)D levels (81.77±5.60 vs. 83.49±6.24 nmol/L, p=0.808). Compared to 24.1% controls with prevalent vitamin D deficiency, mild HT and treated HT patients were significantly different (55.4%, p<0.001) and (70.3%, p<0.001), respectively; no difference was seen in the GD patients (22.9%, p=0.797). Serum 25(OH)D levels were not associated with thyroid function, antithyroid antibodies, and serum cytokines IL-4, IL-17, and TNF-α in patients with AITD. We observed relatively low vitamin D level in mild and treated HT patients, while GD patients had similar 25(OH)D levels to those of healthy individuals. Further studies are imperative to explore the complex etiology of vitamin D deficiency in AITD. SN - 1348-4540 UR - https://www.unboundmedicine.com/medline/citation/28413173/25_Hydroxyvitamin_D_serum_level_in_Hashimoto's_thyroiditis_but_not_Graves'_disease_is_relatively_deficient_ L2 - https://dx.doi.org/10.1507/endocrj.EJ16-0547 DB - PRIME DP - Unbound Medicine ER -