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Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment.
Curr Alzheimer Res. 2017; 14(11):1238-1246.CA

Abstract

BACKGROUND

As a risk factor for Alzheimer's disease (AD), type 2 diabetes mellitus (T2DM) itself causes cognitive impairment and has higher prevalence of mild cognitive impairment (MCI).

OBJECTIVE

The aim of this study was to explore the cognition especially the episodic memory difference, the DMN functional connectivity and DMN-related white matter integrity in patients with both T2DM and amnestic MCI (T2DM-MCI) as compared to patients with T2DM only.

METHODS

Focusing especially on T2DM population, we investigated the default mode network (DMN) through resting-state functional magnetic resonance imaging among 22 elderly T2DM-MCI patients and 24 elderly T2DM patients. Including primarily the bilateral cingulum, hippocampus and uncinate fasciculus, these DMN white matter fibers were also closely associated with episodic memory and the integrity of them was also investigated using diffusion tensor imaging in 19 elderly T2DM-MCI patients and 23 elderly T2DM patients.

RESULTS

Compared with the patients with T2DM, the T2DM-MCI patients performed worse in several areas of cognition besides episodic memory, and showed stronger DMN functional connectivity in the left precuneus and weaker functional connectivity in the left calcarine, as well as decreased integrity of the left cingulate bundle and bilateral uncinate fasciculus. Furthermore, a correlation analysis indicated that higher left calcarine connectivity was associated with better episodic memory performance among the overall group.

CONCLUSION

Our results demonstrated that T2DM patients with comorbid amnestic MCI had abnormal functional connectivity patterns and decreased white matter integrity, which could potentially serve as AD or AD risk biomarkers for early detection of those elderly individuals with T2DM.

Authors+Show Affiliations

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875. China.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875. China.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875. China.Banner Alzheimer's Institute, Phoenix, AZ 85006. United States.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875. China.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875. China.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875. China.Department of Radiology, Beijing Tiantan Hospital, Beijing Neurosurgery Institute, Capital Medical University, Beijing 100050. China.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875. China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28413981

Citation

Qi, Di, et al. "Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent With Amnestic Mild Cognitive Impairment." Current Alzheimer Research, vol. 14, no. 11, 2017, pp. 1238-1246.
Qi D, Wang A, Chen Y, et al. Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment. Curr Alzheimer Res. 2017;14(11):1238-1246.
Qi, D., Wang, A., Chen, Y., Chen, K., Zhang, S., Zhang, J., Li, X., Ai, L., & Zhang, Z. (2017). Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment. Current Alzheimer Research, 14(11), 1238-1246. https://doi.org/10.2174/1567205014666170417113441
Qi D, et al. Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent With Amnestic Mild Cognitive Impairment. Curr Alzheimer Res. 2017;14(11):1238-1246. PubMed PMID: 28413981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment. AU - Qi,Di, AU - Wang,Ailin, AU - Chen,Yaojing, AU - Chen,Kewei, AU - Zhang,Sisi, AU - Zhang,Junying, AU - Li,Xin, AU - Ai,Lin, AU - Zhang,Zhanjun, PY - 2017/01/08/received PY - 2017/04/01/revised PY - 2017/04/11/accepted PY - 2017/4/18/pubmed PY - 2018/6/5/medline PY - 2017/4/18/entrez KW - Type 2 diabetes mellitus KW - default mode network KW - episodic memory KW - functional connectivity KW - mild cognitive impairment KW - white matter integrity SP - 1238 EP - 1246 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 14 IS - 11 N2 - BACKGROUND: As a risk factor for Alzheimer's disease (AD), type 2 diabetes mellitus (T2DM) itself causes cognitive impairment and has higher prevalence of mild cognitive impairment (MCI). OBJECTIVE: The aim of this study was to explore the cognition especially the episodic memory difference, the DMN functional connectivity and DMN-related white matter integrity in patients with both T2DM and amnestic MCI (T2DM-MCI) as compared to patients with T2DM only. METHODS: Focusing especially on T2DM population, we investigated the default mode network (DMN) through resting-state functional magnetic resonance imaging among 22 elderly T2DM-MCI patients and 24 elderly T2DM patients. Including primarily the bilateral cingulum, hippocampus and uncinate fasciculus, these DMN white matter fibers were also closely associated with episodic memory and the integrity of them was also investigated using diffusion tensor imaging in 19 elderly T2DM-MCI patients and 23 elderly T2DM patients. RESULTS: Compared with the patients with T2DM, the T2DM-MCI patients performed worse in several areas of cognition besides episodic memory, and showed stronger DMN functional connectivity in the left precuneus and weaker functional connectivity in the left calcarine, as well as decreased integrity of the left cingulate bundle and bilateral uncinate fasciculus. Furthermore, a correlation analysis indicated that higher left calcarine connectivity was associated with better episodic memory performance among the overall group. CONCLUSION: Our results demonstrated that T2DM patients with comorbid amnestic MCI had abnormal functional connectivity patterns and decreased white matter integrity, which could potentially serve as AD or AD risk biomarkers for early detection of those elderly individuals with T2DM. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/28413981/Default_Mode_Network_Connectivity_and_Related_White_Matter_Disruption_in_Type_2_Diabetes_Mellitus_Patients_Concurrent_with_Amnestic_Mild_Cognitive_Impairment_ L2 - http://www.eurekaselect.com/151651/article DB - PRIME DP - Unbound Medicine ER -