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Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Chem Biol Interact. 2017 May 25; 270:41-50.CB

Abstract

The objective of the current study was to investigate the possible chemopreventive activity of Commiphora molmol resin (myrrh) extract using a rat model of diethylnitrosamine (DEN)/phenobarbital (PB)-induced early stage hepatocarcinogenesis. Here, we pointed to the modulatory effect of myrrh on oxidative stress, angiogenesis, inflammation and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Hepatocarcinogenesis was induced in Wistar rats using DEN for initiation and PB as a promoting agent. The rats received 125 or 250 mg/kg C. molmol resin extract throughout the experiment. Both doses of myrrh improved liver function marker enzymes and prevented oval cells proliferation and the distortion of hepatic architecture. The pro-inflammatory cytokine interleukin-6, tumor markers, angiogenesis markers, lipid peroxidation and nitric oxide (NO) were significantly increased in DEN/PB-induced rats. In addition, the antioxidant defenses showed marked reduction in the liver of DEN/PB-induced rats. Oral administration of C. molmol extract to DEN/PB-induced rats significantly decreased circulating markers of inflammation, tumor proliferation and angiogenesis, and liver lipid peroxidation and NO. In addition, C. molmol markedly ameliorated the antioxidant defenses and up-regulated Nrf2 and hemeoxygenase (HO)-1 in the liver of DEN/PB-induced rats. In conclusion, these results provide evidence that C. molmol resin has a potent chemopreventive activity, possibly by up-regulating the Nrf2/HO-1 signaling and attenuation of inflammation, angiogenesis and oxidative stress.

Authors+Show Affiliations

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. Electronic address: ayman.mahmoud@science.bsu.edu.eg.Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Egypt.Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Beni-Sueif University, Egypt.Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28414157

Citation

Mahmoud, Ayman M., et al. "Commiphora Molmol Resin Attenuates Diethylnitrosamine/phenobarbital-induced Hepatocarcinogenesis By Modulating Oxidative Stress, Inflammation, Angiogenesis and Nrf2/ARE/HO-1 Signaling." Chemico-biological Interactions, vol. 270, 2017, pp. 41-50.
Mahmoud AM, Zaki AR, Hassan ME, et al. Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling. Chem Biol Interact. 2017;270:41-50.
Mahmoud, A. M., Zaki, A. R., Hassan, M. E., & Mostafa-Hedeab, G. (2017). Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling. Chemico-biological Interactions, 270, 41-50. https://doi.org/10.1016/j.cbi.2017.04.012
Mahmoud AM, et al. Commiphora Molmol Resin Attenuates Diethylnitrosamine/phenobarbital-induced Hepatocarcinogenesis By Modulating Oxidative Stress, Inflammation, Angiogenesis and Nrf2/ARE/HO-1 Signaling. Chem Biol Interact. 2017 May 25;270:41-50. PubMed PMID: 28414157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling. AU - Mahmoud,Ayman M, AU - Zaki,Amr R, AU - Hassan,Manal E, AU - Mostafa-Hedeab,Gomaa, Y1 - 2017/04/14/ PY - 2016/12/28/received PY - 2017/04/10/revised PY - 2017/04/13/accepted PY - 2017/4/18/pubmed PY - 2017/5/26/medline PY - 2017/4/18/entrez KW - Carcinogenesis KW - Inflammation KW - Myrrh KW - Nrf2 KW - Oxidative stress SP - 41 EP - 50 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 270 N2 - The objective of the current study was to investigate the possible chemopreventive activity of Commiphora molmol resin (myrrh) extract using a rat model of diethylnitrosamine (DEN)/phenobarbital (PB)-induced early stage hepatocarcinogenesis. Here, we pointed to the modulatory effect of myrrh on oxidative stress, angiogenesis, inflammation and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Hepatocarcinogenesis was induced in Wistar rats using DEN for initiation and PB as a promoting agent. The rats received 125 or 250 mg/kg C. molmol resin extract throughout the experiment. Both doses of myrrh improved liver function marker enzymes and prevented oval cells proliferation and the distortion of hepatic architecture. The pro-inflammatory cytokine interleukin-6, tumor markers, angiogenesis markers, lipid peroxidation and nitric oxide (NO) were significantly increased in DEN/PB-induced rats. In addition, the antioxidant defenses showed marked reduction in the liver of DEN/PB-induced rats. Oral administration of C. molmol extract to DEN/PB-induced rats significantly decreased circulating markers of inflammation, tumor proliferation and angiogenesis, and liver lipid peroxidation and NO. In addition, C. molmol markedly ameliorated the antioxidant defenses and up-regulated Nrf2 and hemeoxygenase (HO)-1 in the liver of DEN/PB-induced rats. In conclusion, these results provide evidence that C. molmol resin has a potent chemopreventive activity, possibly by up-regulating the Nrf2/HO-1 signaling and attenuation of inflammation, angiogenesis and oxidative stress. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/28414157/Commiphora_molmol_resin_attenuates_diethylnitrosamine/phenobarbital_induced_hepatocarcinogenesis_by_modulating_oxidative_stress_inflammation_angiogenesis_and_Nrf2/ARE/HO_1_signaling_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(16)30767-0 DB - PRIME DP - Unbound Medicine ER -