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Differentiation of Junin virus and antigenic variants isolated in vivo by kinetic neutralization assays.
J Gen Virol. 1988 Aug; 69 (Pt 8):2123-7.JG

Abstract

The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persistently infected. Antigenically variant viruses were isolated from the blood and brain of infected cricetids during the acute and chronic stages of the disease. These variants could be distinguished from the parental strain by kinetic neutralization assays using polyclonal antibodies. Some biological properties were shared with the parental virus strain including its virulence for newborn C. musculinus. These variant viruses may play a major role in chronic disease since we have shown that a viral isolate from an infected brain was poorly neutralized by serum obtained from the same animal.

Authors+Show Affiliations

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2841418

Citation

Alché, L E., and C E. Coto. "Differentiation of Junin Virus and Antigenic Variants Isolated in Vivo By Kinetic Neutralization Assays." The Journal of General Virology, vol. 69 (Pt 8), 1988, pp. 2123-7.
Alché LE, Coto CE. Differentiation of Junin virus and antigenic variants isolated in vivo by kinetic neutralization assays. J Gen Virol. 1988;69 (Pt 8):2123-7.
Alché, L. E., & Coto, C. E. (1988). Differentiation of Junin virus and antigenic variants isolated in vivo by kinetic neutralization assays. The Journal of General Virology, 69 (Pt 8), 2123-7.
Alché LE, Coto CE. Differentiation of Junin Virus and Antigenic Variants Isolated in Vivo By Kinetic Neutralization Assays. J Gen Virol. 1988;69 (Pt 8):2123-7. PubMed PMID: 2841418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differentiation of Junin virus and antigenic variants isolated in vivo by kinetic neutralization assays. AU - Alché,L E, AU - Coto,C E, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 2123 EP - 7 JF - The Journal of general virology JO - J Gen Virol VL - 69 (Pt 8) N2 - The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persistently infected. Antigenically variant viruses were isolated from the blood and brain of infected cricetids during the acute and chronic stages of the disease. These variants could be distinguished from the parental strain by kinetic neutralization assays using polyclonal antibodies. Some biological properties were shared with the parental virus strain including its virulence for newborn C. musculinus. These variant viruses may play a major role in chronic disease since we have shown that a viral isolate from an infected brain was poorly neutralized by serum obtained from the same animal. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/2841418/Differentiation_of_Junin_virus_and_antigenic_variants_isolated_in_vivo_by_kinetic_neutralization_assays_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/0022-1317-69-8-2123 DB - PRIME DP - Unbound Medicine ER -