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Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study.
Dement Geriatr Cogn Disord. 2017; 43(5-6):259-268.DG

Abstract

AIM

To investigate the associations between hearing loss and prevalent and incident mild cognitive impairment (MCI), dementia and MCI or dementia (all cases).

METHODS

Cross-sectional and longitudinal analyses of baseline and follow-up data were performed in a population-based cohort. The baseline sample of 2,599 adults aged ≥55 included 1,515 cognitively normal subjects who were followed up to 8 years. Hearing loss at baseline was determined by the whispered voice test, and MCI and dementia by Mini-Mental State Examination screening, Clinical Dementia Rating scale, neurocognitive tests, MRI, and panel consensus diagnosis.

RESULTS

Hearing impairment was associated with increased prevalence of dementia (odds ratio = 3.63, 95% confidence interval [CI] 1.16-11.4, p = 0.027) but not MCI alone or all cases of MCI or dementia, adjusted for sex, age, ethnicity, education, central obesity, hypertension, diabetes, dyslipidemia, smoking, alcohol, leisure time activity, cardiac diseases, and depressive symptoms. Among participants who were cognitively normal at baseline, those with hearing impairment were more likely to develop MCI or dementia (hazard ratio [HR] = 2.30, 95% CI 1.08-4.92, p = 0.032). Hearing loss was associated with elevated but statistically nonsignificant estimates of adjusted HR (1.85, 95% CI 0.78-4.40) for incident MCI alone.

CONCLUSIONS

Hearing loss is independently associated with prevalent dementia and incident MCI or dementia.

Authors+Show Affiliations

Department of Otolaryngology, Ng Teng Fong General Hospital, Singapore, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28420004

Citation

Heywood, Rebecca, et al. "Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings From the Singapore Longitudinal Ageing Study." Dementia and Geriatric Cognitive Disorders, vol. 43, no. 5-6, 2017, pp. 259-268.
Heywood R, Gao Q, Nyunt MSZ, et al. Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study. Dement Geriatr Cogn Disord. 2017;43(5-6):259-268.
Heywood, R., Gao, Q., Nyunt, M. S. Z., Feng, L., Chong, M. S., Lim, W. S., Yap, P., Lee, T. S., Yap, K. B., Wee, S. L., & Ng, T. P. (2017). Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study. Dementia and Geriatric Cognitive Disorders, 43(5-6), 259-268. https://doi.org/10.1159/000464281
Heywood R, et al. Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings From the Singapore Longitudinal Ageing Study. Dement Geriatr Cogn Disord. 2017;43(5-6):259-268. PubMed PMID: 28420004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study. AU - Heywood,Rebecca, AU - Gao,Qi, AU - Nyunt,Ma Shwe Zin, AU - Feng,Lei, AU - Chong,Mei Sian, AU - Lim,Wee Shiong, AU - Yap,Philip, AU - Lee,Tih-Shih, AU - Yap,Keng Bee, AU - Wee,Shiou Liang, AU - Ng,Tze Pin, Y1 - 2017/04/19/ PY - 2017/02/18/accepted PY - 2017/4/19/pubmed PY - 2018/6/19/medline PY - 2017/4/19/entrez KW - Aging KW - Hearing loss KW - Neurocognitive disorders SP - 259 EP - 268 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 43 IS - 5-6 N2 - AIM: To investigate the associations between hearing loss and prevalent and incident mild cognitive impairment (MCI), dementia and MCI or dementia (all cases). METHODS: Cross-sectional and longitudinal analyses of baseline and follow-up data were performed in a population-based cohort. The baseline sample of 2,599 adults aged ≥55 included 1,515 cognitively normal subjects who were followed up to 8 years. Hearing loss at baseline was determined by the whispered voice test, and MCI and dementia by Mini-Mental State Examination screening, Clinical Dementia Rating scale, neurocognitive tests, MRI, and panel consensus diagnosis. RESULTS: Hearing impairment was associated with increased prevalence of dementia (odds ratio = 3.63, 95% confidence interval [CI] 1.16-11.4, p = 0.027) but not MCI alone or all cases of MCI or dementia, adjusted for sex, age, ethnicity, education, central obesity, hypertension, diabetes, dyslipidemia, smoking, alcohol, leisure time activity, cardiac diseases, and depressive symptoms. Among participants who were cognitively normal at baseline, those with hearing impairment were more likely to develop MCI or dementia (hazard ratio [HR] = 2.30, 95% CI 1.08-4.92, p = 0.032). Hearing loss was associated with elevated but statistically nonsignificant estimates of adjusted HR (1.85, 95% CI 0.78-4.40) for incident MCI alone. CONCLUSIONS: Hearing loss is independently associated with prevalent dementia and incident MCI or dementia. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/28420004/Hearing_Loss_and_Risk_of_Mild_Cognitive_Impairment_and_Dementia:_Findings_from_the_Singapore_Longitudinal_Ageing_Study_ L2 - https://www.karger.com?DOI=10.1159/000464281 DB - PRIME DP - Unbound Medicine ER -