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In Vitro and In Vivo Studies on Quercus acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity.
Evid Based Complement Alternat Med. 2017; 2017:4097195.EB

Abstract

Quercus acuta Thunb. (Fagaceae) (QA) is cultivated as a dietary and ornamental plant in China, Japan, South Korea, and Taiwan. It has been widely used as the main ingredient of acorn tofu, a traditional food in China and South Korea. The aim of this study was to determine in vitro and in vivo xanthine oxidase (XO) inhibitory and antihyperuricemic activities of an ethyl acetate extract of QA leaf (QALE) and identify its active phytochemicals using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC) systems. The QALE was found to possess potent in vitro antioxidant and XO inhibitory activities. In vivo study using hyperuricemic mice induced with potassium oxonate demonstrated that the QALE could inhibit hepatic XO activity at a relatively low oral dose (50 mg/kg) and significantly alleviate hyperuricemia to a similar extent as allopurinol. Several active compounds including vitamin E known to possess XO inhibitory activity were identified from the QALE. To the best of our knowledge, this is the first study that reports the active constituents and antihyperuricemic effect of QA, suggesting that it is feasible to use QALE as a food therapy or alternative medicine for alleviating hyperuricemia and gout.

Authors+Show Affiliations

College of Pharmacy, Pusan National University, Geumjeong, Busan 46241, Republic of Korea.Department of Oriental Medicine Materials, Dongshin University, Naju, Jeonnam 58245, Republic of Korea.Department of Environmental Engineering, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.Jeollanamdo Wando Arboretum, Wando, Jeonnam 59105, Republic of Korea.Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.Jeonnam Bioindustry Foundation, Institute of Natural Resources Research, Jangheung, Jeonnam 59338, Republic of Korea.Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28421120

Citation

Yoon, In-Soo, et al. "In Vitro and in Vivo Studies On Quercus Acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity." Evidence-based Complementary and Alternative Medicine : ECAM, vol. 2017, 2017, p. 4097195.
Yoon IS, Park DH, Bae MS, et al. In Vitro and In Vivo Studies on Quercus acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity. Evid Based Complement Alternat Med. 2017;2017:4097195.
Yoon, I. S., Park, D. H., Bae, M. S., Oh, D. S., Kwon, N. H., Kim, J. E., Choi, C. Y., & Cho, S. S. (2017). In Vitro and In Vivo Studies on Quercus acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity. Evidence-based Complementary and Alternative Medicine : ECAM, 2017, 4097195. https://doi.org/10.1155/2017/4097195
Yoon IS, et al. In Vitro and in Vivo Studies On Quercus Acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity. Evid Based Complement Alternat Med. 2017;2017:4097195. PubMed PMID: 28421120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In Vitro and In Vivo Studies on Quercus acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity. AU - Yoon,In-Soo, AU - Park,Dae-Hun, AU - Bae,Min-Suk, AU - Oh,Deuk-Sil, AU - Kwon,Nan-Hui, AU - Kim,Jung-Eun, AU - Choi,Chul-Yung, AU - Cho,Seung-Sik, Y1 - 2017/03/22/ PY - 2016/09/28/received PY - 2016/11/29/revised PY - 2016/12/01/accepted PY - 2017/4/20/entrez PY - 2017/4/20/pubmed PY - 2017/4/20/medline SP - 4097195 EP - 4097195 JF - Evidence-based complementary and alternative medicine : eCAM JO - Evid Based Complement Alternat Med VL - 2017 N2 - Quercus acuta Thunb. (Fagaceae) (QA) is cultivated as a dietary and ornamental plant in China, Japan, South Korea, and Taiwan. It has been widely used as the main ingredient of acorn tofu, a traditional food in China and South Korea. The aim of this study was to determine in vitro and in vivo xanthine oxidase (XO) inhibitory and antihyperuricemic activities of an ethyl acetate extract of QA leaf (QALE) and identify its active phytochemicals using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC) systems. The QALE was found to possess potent in vitro antioxidant and XO inhibitory activities. In vivo study using hyperuricemic mice induced with potassium oxonate demonstrated that the QALE could inhibit hepatic XO activity at a relatively low oral dose (50 mg/kg) and significantly alleviate hyperuricemia to a similar extent as allopurinol. Several active compounds including vitamin E known to possess XO inhibitory activity were identified from the QALE. To the best of our knowledge, this is the first study that reports the active constituents and antihyperuricemic effect of QA, suggesting that it is feasible to use QALE as a food therapy or alternative medicine for alleviating hyperuricemia and gout. SN - 1741-427X UR - https://www.unboundmedicine.com/medline/citation/28421120/In_Vitro_and_In_Vivo_Studies_on_Quercus_acuta_Thunb___Fagaceae__Extract:_Active_Constituents_Serum_Uric_Acid_Suppression_and_Xanthine_Oxidase_Inhibitory_Activity_ L2 - https://dx.doi.org/10.1155/2017/4097195 DB - PRIME DP - Unbound Medicine ER -
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