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Immunophenotypic profiles for distinguishing orbital mucosa-associated lymphoid tissue lymphoma from benign lymphoproliferative tumors.
Jpn J Ophthalmol. 2017 Jul; 61(4):354-360.JJ

Abstract

PURPOSE

To evaluate novel immunophenotypic profiles of patients with orbital lymphoproliferative tumors.

METHODS

From 2006 to 2014, surgical biopsies from consecutive patients with newly diagnosed orbital mucosa-associated lymphoid tissue (MALT) lymphoma and IgG4-related ophthalmic disease (IgG4-ROD) were collected from Tokyo Medical University Hospital. A total of 44 tumors from 44 patients were analyzed, including 21 with orbital MALT lymphoma (11 men and 10 women, mean age 67.8 ± 13.4 years) and 23 with definitive IgG4-ROD (9 men and 14 women, mean age 60.5 ± 15.1 years). Patients with secondary orbital MALT lymphoma and MALT lymphoma with IgG4-ROD were excluded. All patients were immunocompetent Asian adults. Samples were analyzed by immunohistochemistry and flow cytometric analysis. Flow cytometry was performed with the following antibodies: CD3, CD4, CD5, CD8, CD10, CD19, CD20, CD23, CD25, CD30, CD34, and CD56 lambda and kappa chains.

RESULTS

Expression of CD25 and CD19 was higher in patients with orbital MALT lymphoma compared to patients with IgG4-ROD (p < 0.001). In contrast, expression of CD3, CD4, and CD23 was higher in patients with orbital IgG4-ROD compared to those with MALT lymphoma (all p < 0.01). The presence of CD23 and CD25 in the specimens was confirmed by immunohistochemistry.

CONCLUSION

The present study elucidated the novel immunophenotypic features of orbital MALT and benign lymphoproliferative disorders such as IgG4-ROD. Among them, CD23 and CD25 have shown a disease-specific expression pattern.

Authors+Show Affiliations

Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. usuyoshi@gmail.com.Department of Anatomic Pathology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, Japan.David Geffen School of Medicine, University of California, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.Department of Anatomic Pathology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, Japan.Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28421369

Citation

Ueda, Shunichiro, et al. "Immunophenotypic Profiles for Distinguishing Orbital Mucosa-associated Lymphoid Tissue Lymphoma From Benign Lymphoproliferative Tumors." Japanese Journal of Ophthalmology, vol. 61, no. 4, 2017, pp. 354-360.
Ueda S, Usui Y, Nagai T, et al. Immunophenotypic profiles for distinguishing orbital mucosa-associated lymphoid tissue lymphoma from benign lymphoproliferative tumors. Jpn J Ophthalmol. 2017;61(4):354-360.
Ueda, S., Usui, Y., Nagai, T., Diaz-Aguilar, D., Nagao, T., & Goto, H. (2017). Immunophenotypic profiles for distinguishing orbital mucosa-associated lymphoid tissue lymphoma from benign lymphoproliferative tumors. Japanese Journal of Ophthalmology, 61(4), 354-360. https://doi.org/10.1007/s10384-017-0513-1
Ueda S, et al. Immunophenotypic Profiles for Distinguishing Orbital Mucosa-associated Lymphoid Tissue Lymphoma From Benign Lymphoproliferative Tumors. Jpn J Ophthalmol. 2017;61(4):354-360. PubMed PMID: 28421369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunophenotypic profiles for distinguishing orbital mucosa-associated lymphoid tissue lymphoma from benign lymphoproliferative tumors. AU - Ueda,Shunichiro, AU - Usui,Yoshihiko, AU - Nagai,Takeshi, AU - Diaz-Aguilar,Daniel, AU - Nagao,Toshitaka, AU - Goto,Hiroshi, Y1 - 2017/04/18/ PY - 2016/08/29/received PY - 2017/03/13/accepted PY - 2017/4/20/pubmed PY - 2017/11/3/medline PY - 2017/4/20/entrez KW - CD23 KW - CD25 KW - IgG4-related ophthalmic disease KW - Lymphoproliferative disease KW - MALT lymphoma KW - Reactive lymphoid hyperplasia SP - 354 EP - 360 JF - Japanese journal of ophthalmology JO - Jpn. J. Ophthalmol. VL - 61 IS - 4 N2 - PURPOSE: To evaluate novel immunophenotypic profiles of patients with orbital lymphoproliferative tumors. METHODS: From 2006 to 2014, surgical biopsies from consecutive patients with newly diagnosed orbital mucosa-associated lymphoid tissue (MALT) lymphoma and IgG4-related ophthalmic disease (IgG4-ROD) were collected from Tokyo Medical University Hospital. A total of 44 tumors from 44 patients were analyzed, including 21 with orbital MALT lymphoma (11 men and 10 women, mean age 67.8 ± 13.4 years) and 23 with definitive IgG4-ROD (9 men and 14 women, mean age 60.5 ± 15.1 years). Patients with secondary orbital MALT lymphoma and MALT lymphoma with IgG4-ROD were excluded. All patients were immunocompetent Asian adults. Samples were analyzed by immunohistochemistry and flow cytometric analysis. Flow cytometry was performed with the following antibodies: CD3, CD4, CD5, CD8, CD10, CD19, CD20, CD23, CD25, CD30, CD34, and CD56 lambda and kappa chains. RESULTS: Expression of CD25 and CD19 was higher in patients with orbital MALT lymphoma compared to patients with IgG4-ROD (p < 0.001). In contrast, expression of CD3, CD4, and CD23 was higher in patients with orbital IgG4-ROD compared to those with MALT lymphoma (all p < 0.01). The presence of CD23 and CD25 in the specimens was confirmed by immunohistochemistry. CONCLUSION: The present study elucidated the novel immunophenotypic features of orbital MALT and benign lymphoproliferative disorders such as IgG4-ROD. Among them, CD23 and CD25 have shown a disease-specific expression pattern. SN - 1613-2246 UR - https://www.unboundmedicine.com/medline/citation/28421369/Immunophenotypic_profiles_for_distinguishing_orbital_mucosa_associated_lymphoid_tissue_lymphoma_from_benign_lymphoproliferative_tumors_ L2 - https://dx.doi.org/10.1007/s10384-017-0513-1 DB - PRIME DP - Unbound Medicine ER -