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Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control.

Abstract

The yellow fever mosquito, Aedes aegypti, particularly in Neotropical regions, is the principal vector of dengue, yellow fever, Zika and Chikungunya viruses. Pyrethroids remain one of the most used insecticides to control Aedes mosquitoes, despite the development of pyrethroid resistance in many mosquito populations worldwide. Here, we report a Brazilian strain of A. aegypti with high levels (approximately 100-60,000 fold) of resistance to both type I and type II pyrethroids. We detected two mutations (V410L and F1534C) in the sodium channel from this resistant strain. This study is the first report of the V410L mutation in mosquitoes. Alone or in combination with the F1534C mutation, the V410L mutation drastically reduced the sensitivity of mosquito sodium channels expressed in Xenopus oocytes to both type I and type II pyrethroids. The V410L mutation presents a serious challenge for the control of A. aegypti and will compromise the use of pyrethroids for the control of A. aegypti in Brazil; therefore, early monitoring of the frequency of the V410L mutation will be a key resistance management strategy to preserve the effectiveness of pyrethroid insecticides.

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  • Authors+Show Affiliations

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    Departamento de Entomologia, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brasil. Science Without Border Associate Researcher, Programa de Pós-Graduação em Entomologia, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brasil.

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    Departamento de Entomologia, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brasil. EAG Laboratories, 13709 Progress Blvd. #24 Suite S163, Alachua, FL, 32615 USA.

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    Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI, USA.

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    Departamento de Entomologia, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brasil.

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    Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI, USA.

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    Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, M G 36570-900, Brasil.

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    Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI, USA.

    Departamento de Entomologia, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brasil.

    Source

    Scientific reports 7: 2017 Apr 19 pg 46549

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28422157