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Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves.
Int J Lepr Other Mycobact Dis. 1988 Jun; 56(2):283-90.IJ

Abstract

A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 10(7) BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohistochemical, electron microscopical and electrophysiological studies have demonstrated that the lesions induced in the experimental animals show many of the features documented in studies of nerve damage in leprosy patients.

Authors+Show Affiliations

Department of Pathology, Royal College of Surgeons of England, London.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2842415

Citation

Cowley, S A., et al. "Nerve Damage Induced By Mycobacterial Granulomas in Guinea Pig Sciatic Nerves." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 56, no. 2, 1988, pp. 283-90.
Cowley SA, Butter C, Verghese S, et al. Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves. Int J Lepr Other Mycobact Dis. 1988;56(2):283-90.
Cowley, S. A., Butter, C., Verghese, S., Curtis, J., & Turk, J. L. (1988). Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 56(2), 283-90.
Cowley SA, et al. Nerve Damage Induced By Mycobacterial Granulomas in Guinea Pig Sciatic Nerves. Int J Lepr Other Mycobact Dis. 1988;56(2):283-90. PubMed PMID: 2842415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves. AU - Cowley,S A, AU - Butter,C, AU - Verghese,S, AU - Curtis,J, AU - Turk,J L, PY - 1988/6/1/pubmed PY - 1988/6/1/medline PY - 1988/6/1/entrez SP - 283 EP - 90 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 56 IS - 2 N2 - A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 10(7) BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohistochemical, electron microscopical and electrophysiological studies have demonstrated that the lesions induced in the experimental animals show many of the features documented in studies of nerve damage in leprosy patients. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2842415/Nerve_damage_induced_by_mycobacterial_granulomas_in_guinea_pig_sciatic_nerves_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -