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Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada.
J Nutr. 2017 06; 147(6):1145-1151.JN

Abstract

Background:

Maternal vitamin D insufficiency (plasma 25-hydroxyvitamin D [25(OH)D] <75 nmol/L) may play a role in ethnic disparities in rates of preterm and spontaneous preterm births.

Objective:

We explored the relation between maternal plasma 25(OH)D concentration in the first trimester (8-14 wk of gestation) and the risk of preterm and spontaneous preterm births (<37 wk of gestation) by ethnicity.

Methods:

We designed a case-control study that included 120 cases of preterm birth (<37 wk of gestation) and 360 term controls (≥37 wk of gestation) of singleton pregnancies from the 3D cohort, a multicenter study in 2456 pregnant women in Quebec, Canada. Plasma 25(OH)D was measured by LC-mass spectrometry. We compared the distribution of vitamin D status between cases and controls for 8 ethnic minority subgroups. We explored the association between maternal plasma 25(OH)D concentration and preterm and spontaneous preterm births with the use of splines in logistic regression by ethnicity.

Results:

The distributions of maternal vitamin D status (<50, 50-75, and >75 nmol/L) were different in preterm and spontaneous preterm birth cases compared with controls but only in women of ethnic minority (P-trend = 0.003 and 0.024, respectively). Among ethnic subgroups, sub-Saharan Africans (P-trend = 0.030) and Arab-West Asians (P-trend = 0.045) showed an inverse relation between maternal vitamin D status and the risk of preterm birth. Maternal plasma 25(OH)D concentrations of 30 nmol/L were associated with 4.05 times the risk of preterm birth in the total ethnic minority population (95% CI: 1.16, 14.12; P = 0.028) relative to participants with a concentration of 75 nmol/L. In contrast, there was no such association among nonethnic women (OR: 0.94; 95% CI: 0.48, 1.82; P = 0.85). There was no association when we considered only spontaneous preterm births in the total ethnic minority population (OR: 1.75; 95% CI: 0.39, 7.79; P = 0.46).

Conclusion:

Vitamin D insufficiency is associated with an increased risk of preterm birth in ethnic minority women in Canada.

Authors+Show Affiliations

Ste-Justine University Hospital Centre and. Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, Quebec, Canada.University of Montreal Hospital Research Center, Institut National de Santé Publique du Québec, Montreal, Quebec, Canada.Ste-Justine University Hospital Centre and. Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.Ste-Justine University Hospital Centre and. Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada.Research Centre of the Sherbrooke University Hospital (CHUS), Sherbrooke, Quebec, Canada; and Departments of.Research Centre of the Sherbrooke University Hospital (CHUS), Sherbrooke, Quebec, Canada; and Departments of. Biochemistry and.Ste-Justine University Hospital Centre and william.fraser@usherbrooke.ca. Research Centre of the Sherbrooke University Hospital (CHUS), Sherbrooke, Quebec, Canada; and Departments of. Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, Quebec, Canada.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28424259

Citation

Tabatabaei, Negar, et al. "Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated With Increased Risk of Preterm Birth in Ethnic Minority Women in Canada." The Journal of Nutrition, vol. 147, no. 6, 2017, pp. 1145-1151.
Tabatabaei N, Auger N, Herba CM, et al. Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada. J Nutr. 2017;147(6):1145-1151.
Tabatabaei, N., Auger, N., Herba, C. M., Wei, S., Allard, C., Fink, G. D., & Fraser, W. D. (2017). Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada. The Journal of Nutrition, 147(6), 1145-1151. https://doi.org/10.3945/jn.116.241216
Tabatabaei N, et al. Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated With Increased Risk of Preterm Birth in Ethnic Minority Women in Canada. J Nutr. 2017;147(6):1145-1151. PubMed PMID: 28424259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada. AU - Tabatabaei,Negar, AU - Auger,Nathalie, AU - Herba,Catherine M, AU - Wei,Shuqin, AU - Allard,Catherine, AU - Fink,Guy D, AU - Fraser,William D, Y1 - 2017/04/19/ PY - 2016/09/23/received PY - 2016/10/25/revised PY - 2017/03/16/accepted PY - 2017/4/21/pubmed PY - 2017/7/6/medline PY - 2017/4/21/entrez KW - ethnicity KW - pregnancy KW - preterm birth KW - spontaneous preterm birth KW - vitamin D SP - 1145 EP - 1151 JF - The Journal of nutrition JO - J Nutr VL - 147 IS - 6 N2 - Background: Maternal vitamin D insufficiency (plasma 25-hydroxyvitamin D [25(OH)D] <75 nmol/L) may play a role in ethnic disparities in rates of preterm and spontaneous preterm births.Objective: We explored the relation between maternal plasma 25(OH)D concentration in the first trimester (8-14 wk of gestation) and the risk of preterm and spontaneous preterm births (<37 wk of gestation) by ethnicity.Methods: We designed a case-control study that included 120 cases of preterm birth (<37 wk of gestation) and 360 term controls (≥37 wk of gestation) of singleton pregnancies from the 3D cohort, a multicenter study in 2456 pregnant women in Quebec, Canada. Plasma 25(OH)D was measured by LC-mass spectrometry. We compared the distribution of vitamin D status between cases and controls for 8 ethnic minority subgroups. We explored the association between maternal plasma 25(OH)D concentration and preterm and spontaneous preterm births with the use of splines in logistic regression by ethnicity.Results: The distributions of maternal vitamin D status (<50, 50-75, and >75 nmol/L) were different in preterm and spontaneous preterm birth cases compared with controls but only in women of ethnic minority (P-trend = 0.003 and 0.024, respectively). Among ethnic subgroups, sub-Saharan Africans (P-trend = 0.030) and Arab-West Asians (P-trend = 0.045) showed an inverse relation between maternal vitamin D status and the risk of preterm birth. Maternal plasma 25(OH)D concentrations of 30 nmol/L were associated with 4.05 times the risk of preterm birth in the total ethnic minority population (95% CI: 1.16, 14.12; P = 0.028) relative to participants with a concentration of 75 nmol/L. In contrast, there was no such association among nonethnic women (OR: 0.94; 95% CI: 0.48, 1.82; P = 0.85). There was no association when we considered only spontaneous preterm births in the total ethnic minority population (OR: 1.75; 95% CI: 0.39, 7.79; P = 0.46).Conclusion: Vitamin D insufficiency is associated with an increased risk of preterm birth in ethnic minority women in Canada. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/28424259/Maternal_Vitamin_D_Insufficiency_Early_in_Pregnancy_Is_Associated_with_Increased_Risk_of_Preterm_Birth_in_Ethnic_Minority_Women_in_Canada_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.116.241216 DB - PRIME DP - Unbound Medicine ER -