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Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis.
Brain Imaging Behav. 2018 Apr; 12(2):547-563.BI

Abstract

The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM) changes in non-demented amyotrophic lateral sclerosis (ALS) patients with or without cognitive impairment (ALS-motor and ALS-plus, respectively). Nineteen ALS-motor, 31 ALS-plus and 25 healthy controls (HC) underwent 3D-T1-weighted and 30-directional diffusion-weighted imaging on a 3 T MRI scanner. Voxel-based morphometry and tract-based spatial-statistics analysis were performed to examine GM volume (GMV) changes and WM differences in fractional anisotropy (FA), axial and radial diffusivity (AD, RD, respectively). Compared to HC, ALS-motor patients showed decreased GMV in frontal and cerebellar areas and increased GMV in right supplementary motor area, while ALS-plus patients showed diffuse GMV reduction in primary motor cortex bilaterally, frontotemporal areas, cerebellum and basal ganglia. ALS-motor patients had increased GMV in left precuneus compared to ALS-plus patients. We also found decreased FA and increased RD in the corticospinal tract bilaterally, the corpus callosum and extra-motor tracts in ALS-motor patients, and decreased FA and increased AD and RD in motor and several WM tracts in ALS-plus patients, compared to HC. Multimodal neuroimaging confirms motor and extra-motor GM and WM abnormalities in non-demented cognitively-impaired ALS patients (ALS-plus) and identifies early extra-motor brain pathology in ALS patients without cognitive impairment (ALS-motor).

Authors+Show Affiliations

First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece. christidi.f.a@gmail.com.Second Department of Radiology, Attikon University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.Neurological Center Rosenhuegel and Karl Landsteiner Institute for Epilepsy Research and Cognitive Neurology, Vienna, Austria.First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece.Second Department of Psychiatry, Attikon University Hospital, Medical School, National & Kapodistrian University, Athens, Greece.Second Department of Radiology, Attikon University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece.First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece.Second Department of Radiology, Attikon University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece.First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece.Second Department of Radiology, Attikon University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.Second Department of Radiology, Attikon University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.Department of Neurology, Demokritos University of Thrace, Alexandroupolis, Greece.Second Department of Radiology, Attikon University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.Clinic of Neuroradiology, University Hospital Zurich, Zurich, Switzerland.First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece.Second Department of Radiology, Attikon University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28425061

Citation

Christidi, Foteini, et al. "Gray Matter and White Matter Changes in Non-demented Amyotrophic Lateral Sclerosis Patients With or Without Cognitive Impairment: a Combined Voxel-based Morphometry and Tract-based Spatial Statistics Whole-brain Analysis." Brain Imaging and Behavior, vol. 12, no. 2, 2018, pp. 547-563.
Christidi F, Karavasilis E, Riederer F, et al. Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis. Brain Imaging Behav. 2018;12(2):547-563.
Christidi, F., Karavasilis, E., Riederer, F., Zalonis, I., Ferentinos, P., Velonakis, G., Xirou, S., Rentzos, M., Argiropoulos, G., Zouvelou, V., Zambelis, T., Athanasakos, A., Toulas, P., Vadikolias, K., Efstathopoulos, E., Kollias, S., Karandreas, N., Kelekis, N., & Evdokimidis, I. (2018). Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis. Brain Imaging and Behavior, 12(2), 547-563. https://doi.org/10.1007/s11682-017-9722-y
Christidi F, et al. Gray Matter and White Matter Changes in Non-demented Amyotrophic Lateral Sclerosis Patients With or Without Cognitive Impairment: a Combined Voxel-based Morphometry and Tract-based Spatial Statistics Whole-brain Analysis. Brain Imaging Behav. 2018;12(2):547-563. PubMed PMID: 28425061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis. AU - Christidi,Foteini, AU - Karavasilis,Efstratios, AU - Riederer,Franz, AU - Zalonis,Ioannis, AU - Ferentinos,Panagiotis, AU - Velonakis,Georgios, AU - Xirou,Sophia, AU - Rentzos,Michalis, AU - Argiropoulos,Georgios, AU - Zouvelou,Vasiliki, AU - Zambelis,Thomas, AU - Athanasakos,Athanasios, AU - Toulas,Panagiotis, AU - Vadikolias,Konstantinos, AU - Efstathopoulos,Efstathios, AU - Kollias,Spyros, AU - Karandreas,Nikolaos, AU - Kelekis,Nikolaos, AU - Evdokimidis,Ioannis, PY - 2017/4/21/pubmed PY - 2019/3/5/medline PY - 2017/4/21/entrez KW - Amyotrophic lateral sclerosis KW - Cognition KW - Multimodal neuroimaging KW - Tract-based spatial statistics KW - Voxel-based morphometry SP - 547 EP - 563 JF - Brain imaging and behavior JO - Brain Imaging Behav VL - 12 IS - 2 N2 - The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM) changes in non-demented amyotrophic lateral sclerosis (ALS) patients with or without cognitive impairment (ALS-motor and ALS-plus, respectively). Nineteen ALS-motor, 31 ALS-plus and 25 healthy controls (HC) underwent 3D-T1-weighted and 30-directional diffusion-weighted imaging on a 3 T MRI scanner. Voxel-based morphometry and tract-based spatial-statistics analysis were performed to examine GM volume (GMV) changes and WM differences in fractional anisotropy (FA), axial and radial diffusivity (AD, RD, respectively). Compared to HC, ALS-motor patients showed decreased GMV in frontal and cerebellar areas and increased GMV in right supplementary motor area, while ALS-plus patients showed diffuse GMV reduction in primary motor cortex bilaterally, frontotemporal areas, cerebellum and basal ganglia. ALS-motor patients had increased GMV in left precuneus compared to ALS-plus patients. We also found decreased FA and increased RD in the corticospinal tract bilaterally, the corpus callosum and extra-motor tracts in ALS-motor patients, and decreased FA and increased AD and RD in motor and several WM tracts in ALS-plus patients, compared to HC. Multimodal neuroimaging confirms motor and extra-motor GM and WM abnormalities in non-demented cognitively-impaired ALS patients (ALS-plus) and identifies early extra-motor brain pathology in ALS patients without cognitive impairment (ALS-motor). SN - 1931-7565 UR - https://www.unboundmedicine.com/medline/citation/28425061/Gray_matter_and_white_matter_changes_in_non_demented_amyotrophic_lateral_sclerosis_patients_with_or_without_cognitive_impairment:_A_combined_voxel_based_morphometry_and_tract_based_spatial_statistics_whole_brain_analysis_ L2 - https://dx.doi.org/10.1007/s11682-017-9722-y DB - PRIME DP - Unbound Medicine ER -