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Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide via Integral Pharmacokinetics.
Molecules. 2017 Apr 20; 22(4)M

Abstract

In the present study, the rationality for the antiviral effect (H1N1 virus) of Flos Lonicerae Japonicae (FLJ, named JinYinHua)-Fructus forsythiae (FF, named LianQiao) herb couple preparations improved by chito-oligosaccharide (COS) was investigated. We found that the improvement of antiviral activity for four preparations attributed to the enhancement of bioavailability for the FLJ-FF herb couple in vivo, and that caffeic acid derivatives are the most important type of components for antiviral activity. The anti-Influenza virus activity-half maximal inhibitory concentration (IC50), not area under concentration (AUC) was considered as the weighting factor for integrating the pharmacokinetics of caffeic acid derivatives. It was found that the integral absorption, both in vitro and in vivo, especially that in Shuang-Huang-Lian, can be improved significantly by COS, an absorption enhancer based on tight junction. The results indicated that the antiviral activity in four preparations improved by COS was mainly attributed to the integral absorption enhancement of caffeic acid derivatives.

Authors+Show Affiliations

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhouwei19860506@163.com. Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China. zhouwei19860506@163.com. Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China. zhouwei19860506@163.com. Faculty of Health Sciences, University of Macau, Macau SAR, China. zhouwei19860506@163.com.Department of Pharmacy, Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China. yal120_120@163.com.Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Paediatrics, Nanjing University of Chinese Medicine, Nanjing 210021, China. yal120_120@126.com.Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Paediatrics, Nanjing University of Chinese Medicine, Nanjing 210021, China. zhouwei19860506@hotmail.com.College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. bccai@126.com.College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com. Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China. diliuqing@hotmail.com. Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China. diliuqing@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28425933

Citation

Zhou, Wei, et al. "Study On the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide Via Integral Pharmacokinetics." Molecules (Basel, Switzerland), vol. 22, no. 4, 2017.
Zhou W, Yin A, Shan J, et al. Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide via Integral Pharmacokinetics. Molecules. 2017;22(4).
Zhou, W., Yin, A., Shan, J., Wang, S., Cai, B., & Di, L. (2017). Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide via Integral Pharmacokinetics. Molecules (Basel, Switzerland), 22(4). https://doi.org/10.3390/molecules22040654
Zhou W, et al. Study On the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide Via Integral Pharmacokinetics. Molecules. 2017 Apr 20;22(4) PubMed PMID: 28425933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide via Integral Pharmacokinetics. AU - Zhou,Wei, AU - Yin,Ailing, AU - Shan,Jinjun, AU - Wang,Shouchuan, AU - Cai,Baochang, AU - Di,Liuqing, Y1 - 2017/04/20/ PY - 2017/02/22/received PY - 2017/04/08/revised PY - 2017/04/11/accepted PY - 2017/4/21/entrez PY - 2017/4/21/pubmed PY - 2017/6/1/medline KW - Flos Lonicerae Japonicae-Fructus forsythiae herb couple KW - anti-viral activity KW - chito-oligosaccharide KW - integral pharmacokinetics KW - multiple caffeic acid derivatives KW - tight junction JF - Molecules (Basel, Switzerland) JO - Molecules VL - 22 IS - 4 N2 - In the present study, the rationality for the antiviral effect (H1N1 virus) of Flos Lonicerae Japonicae (FLJ, named JinYinHua)-Fructus forsythiae (FF, named LianQiao) herb couple preparations improved by chito-oligosaccharide (COS) was investigated. We found that the improvement of antiviral activity for four preparations attributed to the enhancement of bioavailability for the FLJ-FF herb couple in vivo, and that caffeic acid derivatives are the most important type of components for antiviral activity. The anti-Influenza virus activity-half maximal inhibitory concentration (IC50), not area under concentration (AUC) was considered as the weighting factor for integrating the pharmacokinetics of caffeic acid derivatives. It was found that the integral absorption, both in vitro and in vivo, especially that in Shuang-Huang-Lian, can be improved significantly by COS, an absorption enhancer based on tight junction. The results indicated that the antiviral activity in four preparations improved by COS was mainly attributed to the integral absorption enhancement of caffeic acid derivatives. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/28425933/Study_on_the_Rationality_for_Antiviral_Activity_of_Flos_Lonicerae_Japonicae_Fructus_Forsythiae_Herb_Chito_Oligosaccharide_via_Integral_Pharmacokinetics_ L2 - http://www.mdpi.com/resolver?pii=molecules22040654 DB - PRIME DP - Unbound Medicine ER -