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Growth Differentiation Factor 5 Accelerates Wound Closure and Improves Skin Quality During Repair of Full-Thickness Skin Defects.
Adv Skin Wound Care 2017; 30(5):223-229AS

Abstract

BACKGROUND

A fast and stable wound closure is important, especially for extended and unstable wounds found after burn injuries. Growth can regulate a variety of cellular processes, including those involved in wound healing. Growth differentiation factor 5 (GDF-5) can accelerate fibroblast cell migration, cell proliferation, and collagen synthesis, which are essential for wound healing. Nevertheless, no standardized evaluation of the effect of GDF-5 on the healing of full-thickness wounds has been published to date.

METHODS

Five full-thickness skin defects were created on the backs of 6 minipigs. Three wounds were treated with GDF-5 in different concentrations with the help of a gelatin-collagen carrier, and 2 wounds served as control group. The first was treated with the gelatin carrier and an Opsite film (Smith & Nephew, Fort Worth, Texas), and the other was treated solely with an Opsite film that was placed above all wounds and renewed every second day.

RESULTS

Growth differentiation factor 5 accelerates wound closure (10.91 [SD, 0.99] days) compared with treatment with the carrier alone (11.3 [SD, 1.49] days) and control wounds (13.3 [SD, 0.94] days). Epidermal cell count of wounds treated with GDF-5 revealed a higher number of cells compared with the control group. In addition, mean epidermal thickness was significantly increased in GDF-5-treated wounds compared with the control wounds.

CONCLUSIONS

Because of its ability to improve skin quality, GDF-5 should be considered when developing composite biomaterials for wound healing.

Authors+Show Affiliations

Jennifer L. Schiefer, MD, is Chief Resident, Department of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany. Manuel Held, MD, is a Resident, Clinic for Plastic, Reconstructive, Hand and Burn Surgery, BG Trauma Center, University of Tuebingen, Germany. Paul C Fuchs, MD, is Director, Department of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany. Erhan Demir, MD, is Chief Resident, Department of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany. Frank Plöger, PhD, CPM, is Director of Research and Development, Biopharm GmbH, Heidelberg, Germany. Hans-Eberhard Schaller, MD, is Director, Clinic for Plastic, Reconstructive, Hand and Burn Surgery, BG Trauma Center, University of Tuebingen, Germany. Afshin Rahmanian-Schwarz, MD, is Director, Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, Hospital Traunstein, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28426571

Citation

Schiefer, Jennifer L., et al. "Growth Differentiation Factor 5 Accelerates Wound Closure and Improves Skin Quality During Repair of Full-Thickness Skin Defects." Advances in Skin & Wound Care, vol. 30, no. 5, 2017, pp. 223-229.
Schiefer JL, Held M, Fuchs PC, et al. Growth Differentiation Factor 5 Accelerates Wound Closure and Improves Skin Quality During Repair of Full-Thickness Skin Defects. Adv Skin Wound Care. 2017;30(5):223-229.
Schiefer, J. L., Held, M., Fuchs, P. C., Demir, E., Plöger, F., Schaller, H. E., & Rahmanian-Schwarz, A. (2017). Growth Differentiation Factor 5 Accelerates Wound Closure and Improves Skin Quality During Repair of Full-Thickness Skin Defects. Advances in Skin & Wound Care, 30(5), pp. 223-229. doi:10.1097/01.ASW.0000515078.69041.3c.
Schiefer JL, et al. Growth Differentiation Factor 5 Accelerates Wound Closure and Improves Skin Quality During Repair of Full-Thickness Skin Defects. Adv Skin Wound Care. 2017;30(5):223-229. PubMed PMID: 28426571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth Differentiation Factor 5 Accelerates Wound Closure and Improves Skin Quality During Repair of Full-Thickness Skin Defects. AU - Schiefer,Jennifer L, AU - Held,Manuel, AU - Fuchs,Paul C, AU - Demir,Erhan, AU - Plöger,Frank, AU - Schaller,Hans-Eberhard, AU - Rahmanian-Schwarz,Afshin, PY - 2017/4/21/entrez PY - 2017/4/21/pubmed PY - 2018/2/3/medline SP - 223 EP - 229 JF - Advances in skin & wound care JO - Adv Skin Wound Care VL - 30 IS - 5 N2 - BACKGROUND: A fast and stable wound closure is important, especially for extended and unstable wounds found after burn injuries. Growth can regulate a variety of cellular processes, including those involved in wound healing. Growth differentiation factor 5 (GDF-5) can accelerate fibroblast cell migration, cell proliferation, and collagen synthesis, which are essential for wound healing. Nevertheless, no standardized evaluation of the effect of GDF-5 on the healing of full-thickness wounds has been published to date. METHODS: Five full-thickness skin defects were created on the backs of 6 minipigs. Three wounds were treated with GDF-5 in different concentrations with the help of a gelatin-collagen carrier, and 2 wounds served as control group. The first was treated with the gelatin carrier and an Opsite film (Smith & Nephew, Fort Worth, Texas), and the other was treated solely with an Opsite film that was placed above all wounds and renewed every second day. RESULTS: Growth differentiation factor 5 accelerates wound closure (10.91 [SD, 0.99] days) compared with treatment with the carrier alone (11.3 [SD, 1.49] days) and control wounds (13.3 [SD, 0.94] days). Epidermal cell count of wounds treated with GDF-5 revealed a higher number of cells compared with the control group. In addition, mean epidermal thickness was significantly increased in GDF-5-treated wounds compared with the control wounds. CONCLUSIONS: Because of its ability to improve skin quality, GDF-5 should be considered when developing composite biomaterials for wound healing. SN - 1538-8654 UR - https://www.unboundmedicine.com/medline/citation/28426571/Growth_Differentiation_Factor_5_Accelerates_Wound_Closure_and_Improves_Skin_Quality_During_Repair_of_Full_Thickness_Skin_Defects_ L2 - http://dx.doi.org/10.1097/01.ASW.0000515078.69041.3c DB - PRIME DP - Unbound Medicine ER -