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High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival.
Respir Med. 2017 05; 126:100-104.RM

Abstract

PURPOSE

Interstitial lung disease is a common extra-articular manifestation of rheumatoid arthritis (RA-ILD) and is associated with significant morbidity and mortality. However, limited data exist regarding predictors of mortality. We sought to examine the prognostic value of the high-resolution computed tomography (HRCT) patterns in patients with RA-ILD.

MATERIALS AND METHODS

RA-ILD patients with HRCT patterns of usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP) were identified among a longitudinal cohort of individuals evaluated at National Jewish Health. A total of 158 subjects were included in the study. For each subject, the earliest available HRCT was reviewed independently by two expert thoracic radiologists blinded to clinical data. HRCT patterns were classified as demonstrating definite UIP, possible UIP, or NSIP. Kaplan-Meier curves were generated and survival was compared among the three patterns using a log rank test for trend.

RESULTS

One hundred subjects (63%) had HRCT findings classified as definite UIP, 23 (15%) as possible UIP and 35 (22%) as NSIP. No difference in survival was seen between subjects with definite UIP versus those with possible UIP. The combined group of subjects with either definite- or possible UIP had significantly worse survival than those with NSIP (log-rank p = 0.03).

CONCLUSIONS

In patients with RA-ILD, patients with either definite UIP or possible UIP have equally poor survival when compared to those with an NSIP pattern.

Authors+Show Affiliations

National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.University of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA.University of Kentucky, 740 South Limestone St, Lexington, KY 40536, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA. Electronic address: solomonj@njhealth.org.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28427540

Citation

Yunt, Zulma X., et al. "High Resolution Computed Tomography Pattern of Usual Interstitial Pneumonia in Rheumatoid Arthritis-associated Interstitial Lung Disease: Relationship to Survival." Respiratory Medicine, vol. 126, 2017, pp. 100-104.
Yunt ZX, Chung JH, Hobbs S, et al. High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival. Respir Med. 2017;126:100-104.
Yunt, Z. X., Chung, J. H., Hobbs, S., Fernandez-Perez, E. R., Olson, A. L., Huie, T. J., Keith, R. C., Janssen, W. J., Goldstein, B. L., Lynch, D. A., Brown, K. K., Swigris, J. J., & Solomon, J. J. (2017). High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival. Respiratory Medicine, 126, 100-104. https://doi.org/10.1016/j.rmed.2017.03.027
Yunt ZX, et al. High Resolution Computed Tomography Pattern of Usual Interstitial Pneumonia in Rheumatoid Arthritis-associated Interstitial Lung Disease: Relationship to Survival. Respir Med. 2017;126:100-104. PubMed PMID: 28427540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival. AU - Yunt,Zulma X, AU - Chung,Jonathan H, AU - Hobbs,Stephen, AU - Fernandez-Perez,Evans R, AU - Olson,Amy L, AU - Huie,Tristan J, AU - Keith,Rebecca C, AU - Janssen,William J, AU - Goldstein,Barbara L, AU - Lynch,David A, AU - Brown,Kevin K, AU - Swigris,Jeffrey J, AU - Solomon,Joshua J, Y1 - 2017/03/30/ PY - 2016/12/06/received PY - 2017/03/24/revised PY - 2017/03/28/accepted PY - 2017/4/22/entrez PY - 2017/4/22/pubmed PY - 2017/11/29/medline SP - 100 EP - 104 JF - Respiratory medicine JO - Respir Med VL - 126 N2 - PURPOSE: Interstitial lung disease is a common extra-articular manifestation of rheumatoid arthritis (RA-ILD) and is associated with significant morbidity and mortality. However, limited data exist regarding predictors of mortality. We sought to examine the prognostic value of the high-resolution computed tomography (HRCT) patterns in patients with RA-ILD. MATERIALS AND METHODS: RA-ILD patients with HRCT patterns of usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP) were identified among a longitudinal cohort of individuals evaluated at National Jewish Health. A total of 158 subjects were included in the study. For each subject, the earliest available HRCT was reviewed independently by two expert thoracic radiologists blinded to clinical data. HRCT patterns were classified as demonstrating definite UIP, possible UIP, or NSIP. Kaplan-Meier curves were generated and survival was compared among the three patterns using a log rank test for trend. RESULTS: One hundred subjects (63%) had HRCT findings classified as definite UIP, 23 (15%) as possible UIP and 35 (22%) as NSIP. No difference in survival was seen between subjects with definite UIP versus those with possible UIP. The combined group of subjects with either definite- or possible UIP had significantly worse survival than those with NSIP (log-rank p = 0.03). CONCLUSIONS: In patients with RA-ILD, patients with either definite UIP or possible UIP have equally poor survival when compared to those with an NSIP pattern. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/28427540/High_resolution_computed_tomography_pattern_of_usual_interstitial_pneumonia_in_rheumatoid_arthritis_associated_interstitial_lung_disease:_Relationship_to_survival_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(17)30099-9 DB - PRIME DP - Unbound Medicine ER -