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Relationship between high white blood cell count and insulin resistance (HOMA-IR) in Korean children and adolescents: Korean National Health and Nutrition Examination Survey 2008-2010.
Nutr Metab Cardiovasc Dis 2017; 27(5):456-461NM

Abstract

BACKGROUND AND AIMS

Increasing evidence has indicated that insulin resistance is associated with inflammation. However, few studies have investigated the association between white blood cell (WBC) count and insulin resistance, as measured by a homeostasis model assessment of insulin resistance (HOMA-IR) in a general pediatric population. This study aimed to examine the association between WBC count and insulin resistance as measured by HOMA-IR in a nationally representative sample of children and adolescents.

METHODS AND RESULTS

In total, 2761 participants (1479 boys and 1282 girls) aged 10-18 years were selected from the 2008-2010 Korean National Health and Nutrition Examination Survey. Insulin resistance was defined as a HOMA-IR value greater than the 90th percentile. The odds ratios and 95% confidence intervals for insulin resistance were determined using multiple logistic regression analysis. The mean values of most cardiometabolic variables tended to increase proportionally with WBC count quartiles. The prevalence of insulin resistance significantly increased in accordance with WBC count quartiles in both boys and girls. Compared to individuals in the lowest WBC count quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.84 in boys and 3.20 in girls, after adjusting for age, systolic blood pressure, body mass index, and waist circumference.

CONCLUSION

A higher WBC count was positively associated with an increased risk of insulin resistance in Korean children and adolescents. This study suggests that WBC count could facilitate the identification of children and adolescents with insulin resistance.

Authors+Show Affiliations

Department of Family Medicine, Konkuk University Medical Center, Seoul, Republic of Korea.Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: ukyjhome@yuhs.ac.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28428029

Citation

Park, J-M, et al. "Relationship Between High White Blood Cell Count and Insulin Resistance (HOMA-IR) in Korean Children and Adolescents: Korean National Health and Nutrition Examination Survey 2008-2010." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 27, no. 5, 2017, pp. 456-461.
Park JM, Lee DC, Lee YJ. Relationship between high white blood cell count and insulin resistance (HOMA-IR) in Korean children and adolescents: Korean National Health and Nutrition Examination Survey 2008-2010. Nutr Metab Cardiovasc Dis. 2017;27(5):456-461.
Park, J. M., Lee, D. C., & Lee, Y. J. (2017). Relationship between high white blood cell count and insulin resistance (HOMA-IR) in Korean children and adolescents: Korean National Health and Nutrition Examination Survey 2008-2010. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 27(5), pp. 456-461. doi:10.1016/j.numecd.2017.03.002.
Park JM, Lee DC, Lee YJ. Relationship Between High White Blood Cell Count and Insulin Resistance (HOMA-IR) in Korean Children and Adolescents: Korean National Health and Nutrition Examination Survey 2008-2010. Nutr Metab Cardiovasc Dis. 2017;27(5):456-461. PubMed PMID: 28428029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between high white blood cell count and insulin resistance (HOMA-IR) in Korean children and adolescents: Korean National Health and Nutrition Examination Survey 2008-2010. AU - Park,J-M, AU - Lee,D-C, AU - Lee,Y-J, Y1 - 2017/03/10/ PY - 2016/12/21/received PY - 2017/03/03/revised PY - 2017/03/03/accepted PY - 2017/4/22/pubmed PY - 2017/9/7/medline PY - 2017/4/22/entrez KW - Adolescents KW - Childhood obesity KW - Children KW - HOMA-IR KW - Inflammation KW - Insulin resistance KW - White blood cell SP - 456 EP - 461 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 27 IS - 5 N2 - BACKGROUND AND AIMS: Increasing evidence has indicated that insulin resistance is associated with inflammation. However, few studies have investigated the association between white blood cell (WBC) count and insulin resistance, as measured by a homeostasis model assessment of insulin resistance (HOMA-IR) in a general pediatric population. This study aimed to examine the association between WBC count and insulin resistance as measured by HOMA-IR in a nationally representative sample of children and adolescents. METHODS AND RESULTS: In total, 2761 participants (1479 boys and 1282 girls) aged 10-18 years were selected from the 2008-2010 Korean National Health and Nutrition Examination Survey. Insulin resistance was defined as a HOMA-IR value greater than the 90th percentile. The odds ratios and 95% confidence intervals for insulin resistance were determined using multiple logistic regression analysis. The mean values of most cardiometabolic variables tended to increase proportionally with WBC count quartiles. The prevalence of insulin resistance significantly increased in accordance with WBC count quartiles in both boys and girls. Compared to individuals in the lowest WBC count quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.84 in boys and 3.20 in girls, after adjusting for age, systolic blood pressure, body mass index, and waist circumference. CONCLUSION: A higher WBC count was positively associated with an increased risk of insulin resistance in Korean children and adolescents. This study suggests that WBC count could facilitate the identification of children and adolescents with insulin resistance. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/28428029/Relationship_between_high_white_blood_cell_count_and_insulin_resistance__HOMA_IR__in_Korean_children_and_adolescents:_Korean_National_Health_and_Nutrition_Examination_Survey_2008_2010_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(17)30044-3 DB - PRIME DP - Unbound Medicine ER -