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High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort.

Abstract

BACKGROUND & AIMS

Healthy eating patterns assessed by diet quality indexes (DQIs) have been related to lower risk of colorectal cancer-mostly among whites. We investigated the associations between 4 DQI scores (the Healthy Eating Index 2010 [HEI-2010], the Alternative Healthy Eating Index 2010 [AHEI-2010], the alternate Mediterranean diet score [aMED], and the Dietary Approaches to Stop Hypertension score) and colorectal cancer risk in the Multiethnic Cohort.

METHODS

We analyzed data from 190,949 African American, Native Hawaiian, Japanese American, Latino, and white individuals, 45 to 75 years old, who entered the Multiethnic Cohort study from 1993 through 1996. During an average 16 years of follow-up, 4770 invasive colorectal cancer cases were identified.

RESULTS

Scores from all 4 DQIs associated inversely with colorectal cancer risk; higher scores associated with decreasing colorectal cancer risk (all P's for trend ≤ .003). Associations were not significant for AHEI-2010 and aMED scores in women after adjustment for covariates: for the highest vs lowest quintiles, the hazard ratio for the HEI-2010 score in men was 0.69 (95% confidence interval [CI], 0.59-0.80) and in women was 0.82 (95% CI, 0.70-0.96); for the AHEI-2010 score the hazard ratio in men was 0.75 (95% CI, 0.65-0.85) and in women was 0.90 (95% CI, 0.78-1.04); for the aMED score the hazard ratio in men was 0.84 (95% CI, 0.73-0.97) and in women was 0.96 (95% CI, 0.82-1.13); for the Dietary Approaches to Stop Hypertension score the hazard ratio in men was 0.75 (95% CI, 0.66-0.86) and in women was 0.86 (95% CI, 0.75-1.00). Associations were limited to the left colon and rectum for all indexes. The inverse associations were less strong in African American individuals than in the other 4 racial/ethnic groups.

CONCLUSIONS

Based on an analysis of data from the Multiethnic Cohort Study, high-quality diets are associated with a lower risk of colorectal cancer in most racial/ethnic subgroups.

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  • Authors+Show Affiliations

    ,

    Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii. Electronic address: spark@cc.hawaii.edu.

    ,

    Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

    ,

    Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

    ,

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

    Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

    Source

    Gastroenterology 153:2 2017 08 pg 386-394.e2

    MeSH

    Adenocarcinoma
    African Americans
    Aged
    Cohort Studies
    Colonic Neoplasms
    Diet
    Diet Surveys
    Ethnic Groups
    Feeding Behavior
    Female
    Follow-Up Studies
    Health Status Indicators
    Healthy Diet
    Humans
    Life Style
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Rectal Neoplasms
    Risk Factors
    Sex Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    28428143

    Citation

    Park, Song-Yi, et al. "High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort." Gastroenterology, vol. 153, no. 2, 2017, pp. 386-394.e2.
    Park SY, Boushey CJ, Wilkens LR, et al. High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort. Gastroenterology. 2017;153(2):386-394.e2.
    Park, S. Y., Boushey, C. J., Wilkens, L. R., Haiman, C. A., & Le Marchand, L. (2017). High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort. Gastroenterology, 153(2), pp. 386-394.e2. doi:10.1053/j.gastro.2017.04.004.
    Park SY, et al. High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort. Gastroenterology. 2017;153(2):386-394.e2. PubMed PMID: 28428143.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort. AU - Park,Song-Yi, AU - Boushey,Carol J, AU - Wilkens,Lynne R, AU - Haiman,Christopher A, AU - Le Marchand,Loïc, Y1 - 2017/04/17/ PY - 2017/01/04/received PY - 2017/04/03/revised PY - 2017/04/06/accepted PY - 2017/4/22/pubmed PY - 2017/9/1/medline PY - 2017/4/22/entrez KW - Colon Cancer KW - DASH KW - Food KW - Nutrition SP - 386 EP - 394.e2 JF - Gastroenterology JO - Gastroenterology VL - 153 IS - 2 N2 - BACKGROUND & AIMS: Healthy eating patterns assessed by diet quality indexes (DQIs) have been related to lower risk of colorectal cancer-mostly among whites. We investigated the associations between 4 DQI scores (the Healthy Eating Index 2010 [HEI-2010], the Alternative Healthy Eating Index 2010 [AHEI-2010], the alternate Mediterranean diet score [aMED], and the Dietary Approaches to Stop Hypertension score) and colorectal cancer risk in the Multiethnic Cohort. METHODS: We analyzed data from 190,949 African American, Native Hawaiian, Japanese American, Latino, and white individuals, 45 to 75 years old, who entered the Multiethnic Cohort study from 1993 through 1996. During an average 16 years of follow-up, 4770 invasive colorectal cancer cases were identified. RESULTS: Scores from all 4 DQIs associated inversely with colorectal cancer risk; higher scores associated with decreasing colorectal cancer risk (all P's for trend ≤ .003). Associations were not significant for AHEI-2010 and aMED scores in women after adjustment for covariates: for the highest vs lowest quintiles, the hazard ratio for the HEI-2010 score in men was 0.69 (95% confidence interval [CI], 0.59-0.80) and in women was 0.82 (95% CI, 0.70-0.96); for the AHEI-2010 score the hazard ratio in men was 0.75 (95% CI, 0.65-0.85) and in women was 0.90 (95% CI, 0.78-1.04); for the aMED score the hazard ratio in men was 0.84 (95% CI, 0.73-0.97) and in women was 0.96 (95% CI, 0.82-1.13); for the Dietary Approaches to Stop Hypertension score the hazard ratio in men was 0.75 (95% CI, 0.66-0.86) and in women was 0.86 (95% CI, 0.75-1.00). Associations were limited to the left colon and rectum for all indexes. The inverse associations were less strong in African American individuals than in the other 4 racial/ethnic groups. CONCLUSIONS: Based on an analysis of data from the Multiethnic Cohort Study, high-quality diets are associated with a lower risk of colorectal cancer in most racial/ethnic subgroups. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/28428143/High_Quality_Diets_Associate_With_Reduced_Risk_of_Colorectal Cancer:_Analyses_of_Diet_Quality_Indexes_in_the Multiethnic_Cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(17)35439-2 DB - PRIME DP - Unbound Medicine ER -