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The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis.
Biosci Rep 2017; 37(3)BR

Abstract

Previous reports have suggested a potential association on dietary zinc intake with the risk of pancreatic cancer. Since the associations between different studies were controversial, we therefore conducted a meta-analysis to reassess the relationship between dietary zinc intake and pancreatic cancer risk. A comprehensive search from the databases of PubMed, Embase, Web of Science, and Medline was performed until January 31, 2017. Relative risk (RR) with 95% confidence intervals (CI) derived by using random effect model was used. Sensitivity analysis and publication bias were conducted. Our meta-analysis was based on seven studies involving 1659 cases, including two prospective cohort studies and five case-control studies. The total RR of pancreatic cancer risk for the highest versus the lowest categories of dietary zinc intake was 0.798 (0.621-0.984), with its significant heterogeneity among studies (I2=58.2%, P=0.026). The average Newcastle-Ottawa scale (NOS) score was 7.29, suggesting a high quality. There was no publication bias in the meta-analysis about dietary zinc intake on the risk of pancreatic cancer. Subgroup analyses showed that dietary zinc intake could reduce the risk of pancreatic cancer in case-control studies and among American populations. In conclusion, we found that highest category of dietary zinc intake can significantly reduce the risk of pancreatic cancer, especially among American populations.

Authors+Show Affiliations

Department of Emergency Trauma Surgery, The First People's Hospital of Yunnan Province, Kunming 650032, Yunnan province, China.Department of Emergency Trauma Surgery, The First People's Hospital of Yunnan Province, Kunming 650032, Yunnan province, China xuesonggai@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

28428431

Citation

Li, Li, and Xuesong Gai. "The Association Between Dietary Zinc Intake and Risk of Pancreatic Cancer: a Meta-analysis." Bioscience Reports, vol. 37, no. 3, 2017.
Li L, Gai X. The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis. Biosci Rep. 2017;37(3).
Li, L., & Gai, X. (2017). The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis. Bioscience Reports, 37(3), doi:10.1042/BSR20170155.
Li L, Gai X. The Association Between Dietary Zinc Intake and Risk of Pancreatic Cancer: a Meta-analysis. Biosci Rep. 2017 Jun 30;37(3) PubMed PMID: 28428431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis. AU - Li,Li, AU - Gai,Xuesong, Y1 - 2017/06/08/ PY - 2017/02/17/received PY - 2017/04/16/revised PY - 2017/04/19/accepted PY - 2017/4/22/pubmed PY - 2018/3/7/medline PY - 2017/4/22/entrez KW - Dietary zinc intake KW - Meta-analysis KW - Pancreatic cancer JF - Bioscience reports JO - Biosci. Rep. VL - 37 IS - 3 N2 - Previous reports have suggested a potential association on dietary zinc intake with the risk of pancreatic cancer. Since the associations between different studies were controversial, we therefore conducted a meta-analysis to reassess the relationship between dietary zinc intake and pancreatic cancer risk. A comprehensive search from the databases of PubMed, Embase, Web of Science, and Medline was performed until January 31, 2017. Relative risk (RR) with 95% confidence intervals (CI) derived by using random effect model was used. Sensitivity analysis and publication bias were conducted. Our meta-analysis was based on seven studies involving 1659 cases, including two prospective cohort studies and five case-control studies. The total RR of pancreatic cancer risk for the highest versus the lowest categories of dietary zinc intake was 0.798 (0.621-0.984), with its significant heterogeneity among studies (I2=58.2%, P=0.026). The average Newcastle-Ottawa scale (NOS) score was 7.29, suggesting a high quality. There was no publication bias in the meta-analysis about dietary zinc intake on the risk of pancreatic cancer. Subgroup analyses showed that dietary zinc intake could reduce the risk of pancreatic cancer in case-control studies and among American populations. In conclusion, we found that highest category of dietary zinc intake can significantly reduce the risk of pancreatic cancer, especially among American populations. SN - 1573-4935 UR - https://www.unboundmedicine.com/medline/citation/28428431/The_association_between_dietary_zinc_intake_and_risk_of_pancreatic_cancer:_a_meta_analysis_ L2 - http://www.bioscirep.org/cgi/pmidlookup?view=long&pmid=28428431 DB - PRIME DP - Unbound Medicine ER -