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Metastatic squamous cell carcinoma of colon from esophageal cancer.
Exp Hematol Oncol. 2017; 6:11.EH

Abstract

BACKGROUND

Esophageal cancer including squamous cell carcinoma (SCC) and adenocarcinoma represents 4% of all cancers in the United States. Patients with esophageal cancer frequently present with locally advanced disease, and about 40% of patients have evidence of metastatic disease on presentation. Common sites of metastasis include liver, lung and bone. Here, we present a rare case of colonic metastasis from primary esophageal SCC.

CASE PRESENTATION

A 60-year-old Caucasian male with a history of 20-pack-year cigarette smoking received surgery and adjuvant chemoradiotherapy for locally advanced SCC of larynx. Approximately 9 months later, he developed dysphagia, and found to have a esophageal SCC in the mid-esophagus with regional lymph node involvement. He underwent chemoradiation treatment with good response and improved symptoms but declined subsequent surgical resection for esophageal cancer. About 1 year after the diagnosis of esophageal cancer, he developed blood streaked bowel movement and severe anemia. Colonoscopy showed a 3-cm mass in the proximal ascending colon; biopsy showed metastatic SCC, consistent with metastasis from esophageal primary. He subsequently received palliative radiation to the ascending colon metastatic tumor with improvement of anemia, and remained transfusion independent for more than 3 months.

CONCLUSIONS

Colonic metastasis from esophageal SCC is rare, and associated with poor prognosis. There are no definite features in terms of location, histological differentiation etc. that contribute to colonic metastasis from primary esophageal SCC. The goal of treatment is palliative and data from our and other case reports support the use of chemotherapy and radiation for symptom improvement and disease control.

Authors+Show Affiliations

Department of Hematology-Oncology, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health System, Manhasset, NY 11030 USA.AIS Cancer Center, 2620 Chester Ave, Bakersfield, CA 93301 USA.Division of Gastroenterology and Hepatology, Department of Internal Medicine, Loma Linda University, Loma Linda, CA 92354 USA.Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA 92354 USA.Division of Medical Oncology and Hematology, Department of Internal Medicine, Loma Linda University, 11175 Campus Street, CSP 11015, Loma Linda, CA 92354 USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

28428908

Citation

Garg, Natasha, et al. "Metastatic Squamous Cell Carcinoma of Colon From Esophageal Cancer." Experimental Hematology & Oncology, vol. 6, 2017, p. 11.
Garg N, Stoehr C, Zhao YS, et al. Metastatic squamous cell carcinoma of colon from esophageal cancer. Exp Hematol Oncol. 2017;6:11.
Garg, N., Stoehr, C., Zhao, Y. S., Rojas, H., & Hsueh, C. T. (2017). Metastatic squamous cell carcinoma of colon from esophageal cancer. Experimental Hematology & Oncology, 6, 11. https://doi.org/10.1186/s40164-017-0069-2
Garg N, et al. Metastatic Squamous Cell Carcinoma of Colon From Esophageal Cancer. Exp Hematol Oncol. 2017;6:11. PubMed PMID: 28428908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metastatic squamous cell carcinoma of colon from esophageal cancer. AU - Garg,Natasha, AU - Stoehr,Constance, AU - Zhao,Yan Shi, AU - Rojas,Heather, AU - Hsueh,Chung-Tsen, Y1 - 2017/04/18/ PY - 2017/02/08/received PY - 2017/04/01/accepted PY - 2017/4/22/entrez PY - 2017/4/22/pubmed PY - 2017/4/22/medline KW - Colonic metastasis KW - Esophageal squamous cell carcinoma KW - Radiation SP - 11 EP - 11 JF - Experimental hematology & oncology JO - Exp Hematol Oncol VL - 6 N2 - BACKGROUND: Esophageal cancer including squamous cell carcinoma (SCC) and adenocarcinoma represents 4% of all cancers in the United States. Patients with esophageal cancer frequently present with locally advanced disease, and about 40% of patients have evidence of metastatic disease on presentation. Common sites of metastasis include liver, lung and bone. Here, we present a rare case of colonic metastasis from primary esophageal SCC. CASE PRESENTATION: A 60-year-old Caucasian male with a history of 20-pack-year cigarette smoking received surgery and adjuvant chemoradiotherapy for locally advanced SCC of larynx. Approximately 9 months later, he developed dysphagia, and found to have a esophageal SCC in the mid-esophagus with regional lymph node involvement. He underwent chemoradiation treatment with good response and improved symptoms but declined subsequent surgical resection for esophageal cancer. About 1 year after the diagnosis of esophageal cancer, he developed blood streaked bowel movement and severe anemia. Colonoscopy showed a 3-cm mass in the proximal ascending colon; biopsy showed metastatic SCC, consistent with metastasis from esophageal primary. He subsequently received palliative radiation to the ascending colon metastatic tumor with improvement of anemia, and remained transfusion independent for more than 3 months. CONCLUSIONS: Colonic metastasis from esophageal SCC is rare, and associated with poor prognosis. There are no definite features in terms of location, histological differentiation etc. that contribute to colonic metastasis from primary esophageal SCC. The goal of treatment is palliative and data from our and other case reports support the use of chemotherapy and radiation for symptom improvement and disease control. SN - 2162-3619 UR - https://www.unboundmedicine.com/medline/citation/28428908/Metastatic_squamous_cell_carcinoma_of_colon_from_esophageal_cancer_ L2 - https://ehoonline.biomedcentral.com/articles/10.1186/s40164-017-0069-2 DB - PRIME DP - Unbound Medicine ER -
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